ID A0A5N5Q6T5_PANHP Unreviewed; 855 AA.
AC A0A5N5Q6T5;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN ORFNames=PHYPO_G00007250 {ECO:0000313|EMBL:KAB5586937.1};
OS Pangasianodon hypophthalmus (Striped catfish) (Helicophagus hypophthalmus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Pangasiidae; Pangasianodon.
OX NCBI_TaxID=310915 {ECO:0000313|EMBL:KAB5586937.1, ECO:0000313|Proteomes:UP000327468};
RN [1] {ECO:0000313|EMBL:KAB5586937.1, ECO:0000313|Proteomes:UP000327468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Indonesia {ECO:0000313|EMBL:KAB5586937.1,
RC ECO:0000313|Proteomes:UP000327468};
RC TISSUE=Blood {ECO:0000313|EMBL:KAB5586937.1};
RA Wen M., Zahm M., Roques C., Cabau C., Klopp C., Donnadieu C., Jouanno E.,
RA Avarre J.-C., Campet M., Ha T.T.T., Dugue R., Lampietro C., Louis A.,
RA Herpin A., Echchiki A., Berthelot C., Parey E., Roest-Crollius H.,
RA Braasch I., Postlethwait J., Bobe J., Montfort J., Bouchez O., Begum T.,
RA Schartl M., Guiguen Y.;
RT "A chromosome-scale genome assembly of the striped catfish, Pangasianodon
RT hypophthalmus.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC ECO:0000256|RuleBase:RU003844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAB5586937.1}.
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DR EMBL; VFJC01000002; KAB5586937.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N5Q6T5; -.
DR Proteomes; UP000327468; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0031965; C:nuclear membrane; IEA:TreeGrafter.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IEA:TreeGrafter.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0015485; F:cholesterol binding; IEA:TreeGrafter.
DR GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR FunFam; 2.30.29.30:FF:000011; Oxysterol-binding protein; 1.
DR FunFam; 2.40.160.120:FF:000001; Oxysterol-binding protein; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000327468};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 51..146
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 820..847
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 11..25
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 96941 MW; D40919892B2E4BD4 CRC64;
MSSEEKSSTM SQKISSPSRS NSSTSSKHDS RQDSWEIVEG LRGGLGNVQP PERQEGFMLK
RRKWPMKGWH KRYFFLDKGI LKYAKCAVDI EKGKLHGRID VGLSVMAIKK KSKCIDLDAE
ENIYHLKIKS QELFDEWVSK LRHHRLYRQN EIAMLPPEKP LFSSHFPATS SPSFNESQAA
RKRASLAKQT SLHSPIPFTS QAKVAAWLQC SDDMDRCSKE LSECEAQLLE LNHLLRSMEV
LHRTYSAPAI NALQAFAYDS PKKEKRHPRK WRSKHYSKDN KTTLQVPSCI SSGSVRLHAS
NPNLSSADLA IEKNYPEPLD LPIDVSKLQE DFCRVANSLH TSLKSALGSL MSEKEKLRQM
MEQETCTAPS AQLLGLKGAL ASALAQNSDL RERLCKIHVE SHISEPAVLK NFSTGSLQKQ
ESSDCSRHLV HQASNESRAS ITESLSEFFD AQEVLLSASS SENEPSEDDS YISDISDNIS
MDNFSNEVQN ERLDTDCVEN GIPQGKRRSL LPSPSPNTSN ISLWNILRNN IGKDLSKVAM
PVQLNEPLNT LQRLCEELEY SELLDRAAHT PDPFERMVYI ATFAVSGYAS SYYRAGGKPF
NPVLGETYEC DRPDKGFRFI AEQVSHHPPI SACHAESKNF IFWQDVRWKN KFWGKSMEIV
PVGTTHVVLP GLGDHYEWNK VTSCIHNILS GQRWIEHYGE ISIKNSSSDI CQCKVTFIKA
KYWNSSMNEV EGTVVDHKGK VVHKLFGKWH EGIYCGSPPS ATCIWRTNPM PADYEQYYGF
TKFALELNEL DPQTKPLLPP TDTRLRLDQR LLEEGNVEGA EAQKQRIEQL QRDRRRVLEE
NNMAHQATVL PEIQR
//
