ID A0A5N7AZ87_9EURO Unreviewed; 706 AA.
AC A0A5N7AZ87;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 02-APR-2025, entry version 19.
DE SubName: Full=DNA damage response protein RcaA {ECO:0000313|EMBL:KAE8374150.1};
GN ORFNames=BDV26DRAFT_284530 {ECO:0000313|EMBL:KAE8374150.1};
OS Aspergillus bertholletiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1226010 {ECO:0000313|EMBL:KAE8374150.1, ECO:0000313|Proteomes:UP000326198};
RN [1] {ECO:0000313|EMBL:KAE8374150.1, ECO:0000313|Proteomes:UP000326198}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 29228 {ECO:0000313|EMBL:KAE8374150.1,
RC ECO:0000313|Proteomes:UP000326198};
RG DOE Joint Genome Institute;
RA Kjaerbolling I., Vesth T., Frisvad J.C., Nybo J.L., Theobald S.,
RA Kildgaard S., Isbrandt T., Kuo A., Sato A., Lyhne E.K., Kogle M.E.,
RA Wiebenga A., Kun R.S., Lubbers R.J., Makela M.R., Barry K., Chovatia M.,
RA Clum A., Daum C., Haridas S., He G., LaButti K., Lipzen A., Mondo S.,
RA Riley R., Salamov A., Simmons B.A., Magnuson J.K., Henrissat B.,
RA Mortensen U.H., Larsen T.O., Devries R.P., Grigoriev I.V., Machida M.,
RA Baker S.E., Andersen M.R.;
RT "Friends and foes A comparative genomics studyof 23 Aspergillus species
RT from section Flavi.";
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Nibrin family.
CC {ECO:0000256|ARBA:ARBA00044757}.
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DR EMBL; ML736293; KAE8374150.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A5N7AZ87; -.
DR OrthoDB; 552194at2759; -.
DR Proteomes; UP000326198; Unassembled WGS sequence.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:TreeGrafter.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:InterPro.
DR FunFam; 2.60.200.20:FF:000082; DNA damage response protein RcaA; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR040227; Nibrin-rel.
DR InterPro; IPR032429; Nibrin_BRCT2.
DR InterPro; IPR043014; Nibrin_BRCT2_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR SMART; SM00240; FHA; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000326198}.
FT DOMAIN 37..100
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 374..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..514
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..650
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 706 AA; 79444 MW; 73D36D18898EC552 CRC64;
MPSRASHLNR LPLMWILDSE GDLLDGKRVW LRPGQKYLFG RIRQDGVQHA IQHSSISRKH
MVVEVSHVKD GDGSQIYAKS EIKVIDQSSK CGTEVDGNQI RGESINLTGE EHTIKLGRYQ
HLLRIKWQPV VLTFSFSSKE LKAKDPLAHV RSRLEGLDIK TIIPYIVDKT TYVVQSKRNT
AKGLQALVNG KYIVANSYVD ALVYAATPSD LENLESLSPL EVDFESAWPD PTEHLPPPGK
ELVHRPAEAF APIPDRVNLF EGYTFVFGDT AQFENLHDPI ANGHGKALLY NVENNVTTAD
EIVQFMKNAA GGKGLGRQRA GPGGVVLVRF RTGGEWSIEL SNQVALQTNQ RVVEQSEFLD
AILANDASSL CRTLPSSGPT SSRDISAAPA SQPATMPEEN IHIIDSQAVE DVSQPNKSKS
KGPRVRSFVS KMKTFDDGFD INAIPAHPPD DEDVIMDSLP VMDLDTGSLS GQQTQPRSNL
QEEEDVLSQL LPGANAMKRR RAETSQRTMD SSTSRPKEEV HQPKRQKLDI LEAARQHREA
EEDAQRQRQE EEAELQNSLK DIEKLKGLAI VEEMEMPARK IADEDSRWDE RWNGRKNFKK
FRKRGDRNRS RHMIQTVIVP LEEVTRKDFG IGVHYWISSH SKSTENSQAE SLREPPISEQ
DTGESRPQSL ARTESELAAS RSQKRPREER DSDSDDGLRF RFRRRK
//
