ID A0A5N7DTU8_9EURO Unreviewed; 156 AA.
AC A0A5N7DTU8;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 18-JUN-2025, entry version 18.
DE RecName: Full=Eukaryotic translation initiation factor 5A {ECO:0000256|RuleBase:RU362005};
DE Short=eIF-5A {ECO:0000256|RuleBase:RU362005};
GN ORFNames=BDV37DRAFT_235099 {ECO:0000313|EMBL:KAE8409786.1};
OS Aspergillus pseudonomiae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1506151 {ECO:0000313|EMBL:KAE8409786.1, ECO:0000313|Proteomes:UP000325579};
RN [1] {ECO:0000313|EMBL:KAE8409786.1, ECO:0000313|Proteomes:UP000325579}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119388 {ECO:0000313|EMBL:KAE8409786.1,
RC ECO:0000313|Proteomes:UP000325579};
RG DOE Joint Genome Institute;
RA Mondo S., Kjaerbolling I., Vesth T., Frisvad J.C., Nybo J.L., Theobald S.,
RA Kildgaard S., Isbrandt T., Kuo A., Sato A., Lyhne E.K., Kogle M.E.,
RA Wiebenga A., Kun R.S., Lubbers R.J., Makela M.R., Barry K., Chovatia M.,
RA Clum A., Daum C., Haridas S., He G., LaButti K., Lipzen A., Riley R.,
RA Salamov A., Simmons B.A., Magnuson J.K., Henrissat B., Mortensen U.H.,
RA Larsen T.O., Devries R.P., Grigoriev I.V., Machida M., Baker S.E.,
RA Andersen M.R., Cantor M.N., Hua S.X.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor that promotes translation elongation and
CC termination, particularly upon ribosome stalling at specific amino acid
CC sequence contexts. Binds between the exit (E) and peptidyl (P) site of
CC the ribosome and promotes rescue of stalled ribosome: specifically
CC required for efficient translation of polyproline-containing peptides
CC as well as other motifs that stall the ribosome. Acts as ribosome
CC quality control (RQC) cofactor by joining the RQC complex to facilitate
CC peptidyl transfer during CAT tailing step.
CC {ECO:0000256|RuleBase:RU362005}.
CC -!- PTM: eIF-5A seems to be the only eukaryotic protein to have a hypusine
CC residue which is a post-translational modification of a lysine by the
CC addition of a butylamino group. {ECO:0000256|RuleBase:RU362005}.
CC -!- SIMILARITY: Belongs to the eIF-5A family.
CC {ECO:0000256|ARBA:ARBA00006016, ECO:0000256|RuleBase:RU362005}.
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DR EMBL; ML736738; KAE8409786.1; -; Genomic_DNA.
DR RefSeq; XP_031947105.1; XM_032080436.1.
DR AlphaFoldDB; A0A5N7DTU8; -.
DR GeneID; 43665127; -.
DR OrthoDB; 9975114at2759; -.
DR Proteomes; UP000325579; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0045901; P:positive regulation of translational elongation; IEA:UniProtKB-UniRule.
DR GO; GO:0045905; P:positive regulation of translational termination; IEA:UniProtKB-UniRule.
DR CDD; cd04468; S1_eIF5A; 1.
DR FunFam; 2.40.50.140:FF:000034; Eukaryotic translation initiation factor 5A; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR001884; IF5A-like.
DR InterPro; IPR048670; IF5A-like_N.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR020189; Transl_elong_IF5A_C.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR NCBIfam; TIGR00037; eIF_5A; 1.
DR PANTHER; PTHR11673; TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER; 1.
DR Pfam; PF01287; eIF-5a; 1.
DR Pfam; PF21485; IF5A-like_N; 1.
DR PIRSF; PIRSF003025; eIF5A; 1.
DR SMART; SM01376; eIF-5a; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000313|EMBL:KAE8409786.1};
KW Elongation factor {ECO:0000313|EMBL:KAE8409786.1};
KW Hypusine {ECO:0000256|ARBA:ARBA00023071, ECO:0000256|RuleBase:RU362005};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU362005};
KW Reference proteome {ECO:0000313|Proteomes:UP000325579}.
FT DOMAIN 83..150
FT /note="Translation elongation factor IF5A C-terminal"
FT /evidence="ECO:0000259|SMART:SM01376"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 156 AA; 16685 MW; 50BACCA7932EB68E CRC64;
MSDDEQNYEV FDGRSAGGSG TSSVACSTLC KNRFVVINGR PCKINDISID ASESATRVNG
VDIFTGAQLE LKSYPGDFVD VPSVALHEYS LVNVDDGFLN LMSADNTAKD DVKVPPGDLG
SQIDHGFKEG KDLLITVMTA MGEQAAVRFR EAPKGF
//
