ID A0A5R8QF24_9FIRM Unreviewed; 869 AA.
AC A0A5R8QF24;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=P-type Ca(2+) transporter {ECO:0000256|ARBA:ARBA00012790};
DE EC=7.2.2.10 {ECO:0000256|ARBA:ARBA00012790};
GN ORFNames=FEZ08_02845 {ECO:0000313|EMBL:TLG76572.1};
OS Culicoidibacter larvae.
OC Bacteria; Bacillati; Bacillota; Culicoidibacteria; Culicoidibacterales;
OC Culicoidibacteraceae; Culicoidibacter.
OX NCBI_TaxID=2579976 {ECO:0000313|EMBL:TLG76572.1, ECO:0000313|Proteomes:UP000306912};
RN [1] {ECO:0000313|EMBL:TLG76572.1, ECO:0000313|Proteomes:UP000306912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS-1 {ECO:0000313|EMBL:TLG76572.1,
RC ECO:0000313|Proteomes:UP000306912};
RA Neupane S., Ghosh A., Gunther S., Martin K., Zurek L.;
RT "Culicoidintestinum kansasii gen. nov., sp. nov. from the gastrointestinal
RT tract of the biting midge, Culicoides sonorensis.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+);
CC Xref=Rhea:RHEA:18105, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29108, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:456216; EC=7.2.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00048694};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IIA subfamily. {ECO:0000256|ARBA:ARBA00005675}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TLG76572.1}.
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DR EMBL; VBWP01000002; TLG76572.1; -; Genomic_DNA.
DR RefSeq; WP_138190209.1; NZ_VBWP01000002.1.
DR AlphaFoldDB; A0A5R8QF24; -.
DR FunCoup; A0A5R8QF24; 216.
DR InParanoid; A0A5R8QF24; -.
DR OrthoDB; 9760364at2; -.
DR Proteomes; UP000306912; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005388; F:P-type calcium transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005391; F:P-type sodium:potassium-exchanging transporter activity; IEA:TreeGrafter.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IEA:TreeGrafter.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:TreeGrafter.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:TreeGrafter.
DR FunFam; 2.70.150.10:FF:000016; Calcium-transporting P-type ATPase putative; 1.
DR FunFam; 3.40.50.1000:FF:000028; Calcium-transporting P-type ATPase, putative; 1.
DR FunFam; 3.40.50.1000:FF:000001; Phospholipid-transporting ATPase IC; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR059000; ATPase_P-type_domA.
DR InterPro; IPR050510; Cation_transp_ATPase_P-type.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 3.
DR PANTHER; PTHR43294:SF20; P-TYPE ATPASE; 1.
DR PANTHER; PTHR43294; SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000306912};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 55..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 741..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..791
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 811..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..75
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 869 AA; 94506 MW; EC15F897DFC54166 CRC64;
MWSKKNVDEV LTELGTDIET GLTQSTYEQS LAKNGPNKLP EEGRKSPIVI FFKNFLEPLV
IVLLLAAAIS LFVGEAKEAI VIVIIVVINA IIGTVQEVRS QKSLDALKQL STPQVTVRRN
GETVEVDSTS LVPGDIVVLD AGKFIPADLR IVESAQLQID ESALTGESVP VNKKSAAITD
EGNIALGDQI NMAFMSTFIT NGRAVGVVIG TGLNTEIGKI ASMISEAPDT KTPLQEKLAQ
LTKVVSILAF VLGGIILALE IFMGNVVGEA LISAITLAVA VIPESLPVIV SIVLAISVSR
MVKHHAIIKK LPAVETLGAV NVICSDKTGT LTQNKMTVVK YLLNNKTFEP DNFDLNDNTH
EIFLRSLELC NDSFFNDDNQ PIGDPTEVAL TAFAGLQGWN EFTIRKEFPR VDEQPFDSDR
KLMTTVNQHK EQFVVYTKGA TDQLLERCSK IILDGTVVSM TDGFKAEIMA QANEMSEDAL
RVLGFAYKEI AELDPENDYE YNLTFIGCVG MIDPARPEAA SAIARATKAS IETVMITGDH
RVTAFAIAKN LGIVDDEAEV ISGSELDEMD DEQLAKVIRN YHVFARVSPE HKVRIVKALQ
SHGLIVSMTG DGVNDAPSLQ TADIGVAMGI TGTDVSKEAA DMILTDDNFA TIVGAVEEGR
NIYKKIRRAI AFVLSTNLGE VLAVFIAVIV SGYQPLSAVH ILWVNLIVES IIAIPMGMDV
NDPDVMNDKP RPRNESLFTN MVFRILFVAF TTMAAVLTAY FIGLQDPNDT IANAQTMAFL
VMATAPMLTS LSMRSEKWVF FTKKMFANRN LIIAIIAGIT LNFLAVFTPL SAFLGLVPLE
INETIITISL MIIPALLLEL SKIVVKQKR
//
