ID A0A5S4ZS78_9FIRM Unreviewed; 644 AA.
AC A0A5S4ZS78;
DT 26-FEB-2020, integrated into UniProtKB/TrEMBL.
DT 26-FEB-2020, sequence version 1.
DT 28-JAN-2026, entry version 26.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=LX24_01987 {ECO:0000313|EMBL:TYO94971.1};
OS Desulfallas thermosapovorans DSM 6562.
OC Bacteria; Bacillati; Bacillota; Clostridia; Eubacteriales; Desulfallaceae;
OC Desulfallas.
OX NCBI_TaxID=1121431 {ECO:0000313|EMBL:TYO94971.1, ECO:0000313|Proteomes:UP000323166};
RN [1] {ECO:0000313|EMBL:TYO94971.1, ECO:0000313|Proteomes:UP000323166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6562 {ECO:0000313|EMBL:TYO94971.1,
RC ECO:0000313|Proteomes:UP000323166};
RA Kyrpides N.;
RT "Genomic Encyclopedia of Type Strains, Phase I: the one thousand microbial
RT genomes (KMG-I) project.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:TYO94971.1}.
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DR EMBL; VNHM01000010; TYO94971.1; -; Genomic_DNA.
DR RefSeq; WP_166511991.1; NZ_VNHM01000010.1.
DR AlphaFoldDB; A0A5S4ZS78; -.
DR Proteomes; UP000323166; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:TYO94971.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000323166}.
FT DOMAIN 1..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 644 AA; 71206 MW; 2850D86FD76335F1 CRC64;
MKHVIIGTAG HVDHGKTVLI KALTGVDTDR LKEEKERGIS IELGFAYLKL ASGQTAGIID
VPGHERFIKN MLAGVGGIDI VLLVIAADEG VMPQTREHMD IIQLLNIERG IVVITKKDLV
DKEWLDMVTE DIQDFVKGTV LEKAPLVKVS AVNGEGMEEL LQTINQIAAD IKARQSAGPP
RMPVDRVFTV TGFGTVATGT LLDGQIKTGD SLQIYPAGGV YRVRNLQVHG RKVDIAEAGQ
RVAINLSGLE ACELKRGQVL AAPGSLQPNH RLDVKLRFLS SAPKPLKHRT RVRVYLGTAE
ILARVILLDR EELEPGTEAY VQLQLEEPVA TARGDHLVIR SYSPMRTIGG GLVIDPTAGK
HKRYRKDTID ALATAEKGTP TELLEQYLAA TARLCTQSDL TTGAGLAADT VTSALQDLLT
RERIVKLIYE GEIYYLSAPV MNRWEDKIKQ TLAEYHQSFP LREGYPKEEL RSRLFPTLNN
KQFQMVLIHL KQTGGIELHA NSVALQGFTP EPDNIQRTGI KRLEEIYLAN PFQPPNWSDA
AREAGISKDD QEILNYLLAR GTIVKVADGL FFHHQALTEA VELVKDHLAR RGELLLGEVR
DLLHTSRKYT LPLLEYLDNK KITRRVGDKR VAGRALSIDK AANN
//
