ID A0A662YYM3_ACIRT Unreviewed; 542 AA.
AC A0A662YYM3;
DT 22-APR-2020, integrated into UniProtKB/TrEMBL.
DT 22-APR-2020, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|EMBL:RXN01755.1};
GN ORFNames=EOD39_5301 {ECO:0000313|EMBL:RXN01755.1};
OS Acipenser ruthenus (Sterlet sturgeon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX NCBI_TaxID=7906 {ECO:0000313|EMBL:RXN01755.1, ECO:0000313|Proteomes:UP000289886};
RN [1] {ECO:0000313|EMBL:RXN01755.1, ECO:0000313|Proteomes:UP000289886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WHYD16114868_AA {ECO:0000313|EMBL:RXN01755.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RXN01755.1};
RA Wei Q.;
RT "Draft Genome and Complete Hox-Cluster Characterization of the Sterlet
RT Sturgeon (Acipenser ruthenus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXN01755.1}.
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DR EMBL; SCEB01000020; RXN01755.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A662YYM3; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000289886; Unassembled WGS sequence.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR FunFam; 3.30.505.10:FF:000028; Suppressor of cytokine signaling 5; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000289886};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 387..482
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 477..526
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 103..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 542 AA; 61454 MW; 15EE2A9F8DD4595E CRC64;
MDKVGKMWNN LKNRCQNLFH LEGGNRSENM DVNVNRCSLE EDGGTCLSDT PSQRLGICPM
PLHNSAWRNP NCVSEISEIV EITIDQDSED LRTRTGMRLA RRDSYTRHAP WGSKKKHSAK
TQSSLETDKR FSRTCGGLQR RERRYGVSSM HDMDAASSRS LSSLTLRQRL QDTVGLCFPI
RSHSRSTKAL FSTKRKIHLS ELMLEKCPFP SGSDLAQKWH LIKQHTAPAS PQATTLLDTF
DPAVTSTEDE EDRLRERRRL SIEEGVDPPP NAQIHSFEAM PQVNSLYKLG PKLAPGASDL
TGDNRGAAAA AVGGVPTTVV VAAAPLQIDC DSEEDTTTLC LQSRRPKQRH MSGDSHFSRQ
GPWKVHTQID YIHCLVPDLL RITSNPCYWG VMDRYEAEAL LEGKPEGTFL LRDSAQEDYL
FSVSFRRYNR SLHARIEQWN HNFSFDAHDP CVFHSSTVSG LLEHYKDPSS CMFFEPLLTV
PLNRNFPFSL QYICRAAISR CTSYDGIGAL PLPSVLQDFL KEYHYKQKVR VRWLEREPVK
VK
//
