ID A0A663DU83_AQUCH Unreviewed; 1048 AA.
AC A0A663DU83;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 29.
DE RecName: Full=RecQ-like DNA helicase BLM {ECO:0000256|ARBA:ARBA00073450};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase BLM {ECO:0000256|ARBA:ARBA00044542};
GN Name=BLM {ECO:0000313|Ensembl:ENSACCP00020003498.1};
OS Aquila chrysaetos chrysaetos.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC Accipitriformes; Accipitridae; Accipitrinae; Aquila.
OX NCBI_TaxID=223781 {ECO:0000313|Ensembl:ENSACCP00020003498.1, ECO:0000313|Proteomes:UP000472275};
RN [1] {ECO:0000313|Ensembl:ENSACCP00020003498.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSACCP00020003498.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A663DU83; -.
DR Ensembl; ENSACCT00020003629.1; ENSACCP00020003498.1; ENSACCG00020002368.1.
DR GeneTree; ENSGT00940000156800; -.
DR Proteomes; UP000472275; Chromosome 5.
DR GO; GO:0005694; C:chromosome; IEA:TreeGrafter.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IEA:TreeGrafter.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR GO; GO:0000723; P:telomere maintenance; IEA:TreeGrafter.
DR CDD; cd18016; DEXHc_RecQ2_BLM; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR FunFam; 1.10.150.80:FF:000003; Bloom syndrome RecQ-like helicase; 1.
DR FunFam; 3.40.50.300:FF:000537; Bloom syndrome RecQ-like helicase; 1.
DR FunFam; 3.40.50.300:FF:000340; Bloom syndrome, RecQ helicase; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR012532; BDHCT.
DR InterPro; IPR032439; BDHCT_assoc.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR PANTHER; PTHR13710:SF153; RECQ-LIKE DNA HELICASE BLM; 1.
DR Pfam; PF08072; BDHCT; 1.
DR Pfam; PF16204; BDHCT_assoc; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000472275};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 304..479
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 505..652
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 840..920
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 954..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..976
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1015
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 116963 MW; D215931B626BD4FC CRC64;
MDDICKLVDT IPLHELKFLS CAKELLQQRD LRRKLVANSV TLNKSSINNT SRNWKVCVEQ
GPLVCPGTAL CSGPNWSFSS DRNSPKSTNV PSMLSGTVNS NNFSTKKNQT LDASYTSKRT
SLSLCSEMSL DSSCCEKPGV RNSGNQHLLE RPLTSTALKG QSKAPTGIPA GDGLGINDIG
FDLDHFDIDD FDEDWENSVN VSVPETPSTP PYQPVREGPP AKSLLSKIMS RAKGSAVVSN
PAAPKSSFLM ATKNCSGKLC SLGLLSFPFK IFIYLFLNLR PKMMNIFHKK FGLHYFRTNQ
LEAINAALLG EDCFILMPTG GGKSLCYQLP ACVSAGVTIV ISPLRSLIID QVQKLKTLDI
AATHLTGDRT DADASKIYMQ LSKKDPVIKL LYVTPEKICA SNRLMSALEN LYDRKLLARF
VIDEAHCVSQ WGHDFRQDYK RLNMLRKKFH SVPMMALTAT ANPRVQKDIQ NQLEMLKPQV
FTMSFNRHNL KYDVLPKKPK KVAMDCLEWI KKYHPHDSGI IYCLSRHECD TTAAILQKEG
LAALAYHAGL TDSNRDLVQK KWINQEGCQV ICATIAFGMG IDKPDVRYVI HASLPKSIEG
YYQESGRAGR DGEMSHCLLF YSYSDVTRLR RLILMEKDGN SHTRQTHFNN LYSMVHYCEN
VVDCRRIQLL AYFGETNFNP TFCKDHPEVV CDNCSRTKDY KSRNVTDEVK SIIRFVQQHC
GQMGRINAKR STGSGRYTLN MMVDIFLGTT NAKIQSGIFG KGAAYSRHNV ERLFRKLVLD
KILDEDLYIT ANDQAVAYVI LGEKAQAVLD GLLQVEFHVT ESASAIRKQR ASTAKMSQRE
EMVKKCLGEL TDTCKMLGKV FDVHYFNIFS TSTLKKIAET LSSDVEVLLQ IDGVTEDKLE
KYGAEIIKVM DKYSEWTKPE DACQSMDTAM GSAGSPESDE EAEGVVTTSS YFCNNANQRR
KRKRPPNFRG SKRKKTSNGG NQQFHPKGGY SKYRRTKRPS SSKAPASSGC SSASYSVSAT
QGAAGKLGIM APPKPQTRQF LQPSYSIF
//
