ID A0A663DY63_AQUCH Unreviewed; 1228 AA.
AC A0A663DY63;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Multiple EGF like domains 6 {ECO:0000313|Ensembl:ENSACCP00020004694.1};
GN Name=MEGF6 {ECO:0000313|Ensembl:ENSACCP00020004694.1};
OS Aquila chrysaetos chrysaetos.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC Accipitriformes; Accipitridae; Accipitrinae; Aquila.
OX NCBI_TaxID=223781 {ECO:0000313|Ensembl:ENSACCP00020004694.1, ECO:0000313|Proteomes:UP000472275};
RN [1] {ECO:0000313|Ensembl:ENSACCP00020004694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSACCP00020004694.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A663DY63; -.
DR Ensembl; ENSACCT00020004894.1; ENSACCP00020004694.1; ENSACCG00020003162.1.
DR GeneTree; ENSGT00940000156971; -.
DR Proteomes; UP000472275; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR FunFam; 2.10.25.10:FF:000326; Multiple EGF like domains 6; 1.
DR FunFam; 2.170.300.10:FF:000002; Multiple epidermal growth factor-like domains 10; 2.
DR FunFam; 2.10.25.10:FF:000010; Pro-epidermal growth factor; 1.
DR FunFam; 2.10.25.10:FF:000028; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000037; Signal peptide, CUB domain and EGF-like domain-containing 2; 2.
DR FunFam; 2.170.300.10:FF:000041; Tyrosine protein kinase receptor tie-1, putative; 2.
DR FunFam; 2.10.25.10:FF:000240; Vitamin K-dependent protein S; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 4.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR052108; MEGF/SIB.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR PANTHER; PTHR24035:SF137; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00053; EGF_laminin; 4.
DR Pfam; PF14670; FXa_inhibition; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 22.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00180; EGF_Lam; 14.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 12.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50027; EGF_LAM_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472275};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 171..211
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 526..562
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 570..605
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 664..710
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 783..819
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 827..862
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 960..995
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1008..1038
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 552..561
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 595..604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 683..692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 809..818
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 852..861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 985..994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1028..1037
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1228 AA; 130918 MW; 4127C8275D8E112C CRC64;
RPNDMLLRNA DDMIILYVLL LPVGGGTALF SQQRADPRTP LFLCARPNVC AEQELAIVGH
RQPCAQAFTR TVKVWKQDCG GQRWCTGYER RYVFFLRACF APRSGLLSCG SPTRSGSSSS
PALPFSSLPD VNECEAGNGG CESQCCNTIG SFYCKCAAGL RLEPDGKACA DVDECQVHNG
GCQHRCVNTL GSYYCECKPG FRLHTDGRTC IAVNTCALNN GGCEHNCVQV TLTQHQCQCR
HNYQLREDGK RCVRENPCTD RNGGCMHRCH NHRGTARCEC HPGYRLAPDN KACEDVNECL
TGLAMCAHRC LNTRGSFKCT CNPGYELGAD GKQCYRIEME IVNSCEANNG GCSHTCHHTS
SGPVCTCNFG YRLEEDQKTC TDINECDSGS HCCQQDCYNY PGGYECACYA GYRLGTDGCG
CDDVDECSSH NGGCEHTCQN QLGSFQCGCE IGYKLDDDRR SCIPIEDPVE ALDGRRPVIR
PIPHVAILRD EFTQLFNDDY EEEEEEMEAR GEHTLSEKFV CLEHTFGPDC SLTCEDCQNG
ATCDAEETGC ECPAGWTGIL CNQTCPVGTF GRNCSLTCRC QNGGTCDPAT GACRCPPGVA
GELCQDGCPK GFFGKQCRKK CNCANRGRCH RIYGACLCDP GLYGRYCHLV CPKWAFGPGC
SEECRCVQQN TQDCDKRDGS CRCKPGYRGK RCCDPGYYGD GCKKKCSCSP EASCDRVTGE
CWKECPPGYH GENCGQECPE GKFGAGCRRS CSCGGSPCDR STGQCLCLPG WTGHDCACPD
GRWGQGCQEI CPECANNASC DPATGACLCP PGYTGSRCQD VCPPGWFGPD CQLSCSCGND
GHCHPVTGTC SCAPGWTGYN CQRACDAGRW GPDCAHTCNC SNSDGSCSAE TGQCVCDAGY
TGGRCEKSEC CPAQGLFGAR CEEPCDCGDN VSCHHVTGAC DCPRGWRGRR CEKGCPAGRY
GKDCARVCSC GEGATCHPVT GDCVCPPGRA GPTCEQGCEK HRYGAGCRQT CSCRNGGLCD
AADGSCLCAL GWTGKSCELE CPPGRYGASC QLRCACLHNA TCDPGTGACR CSAGRYGPLC
EHSCPPGFHG AGCRERCDCE HGAGCDPATG RCRCPAGLRG ERCQTGCKEG TYGEGCQHLC
DCAGDAPCHP ATGRCLCPPG KTGPKCGSGE RQKALCLILR SATTASSCLS APPHQTAGRP
STAPTAACPA SVPPAAPTVM LRTASASV
//
