ID A0A663F1T5_AQUCH Unreviewed; 520 AA.
AC A0A663F1T5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE RecName: Full=Lysophospholipid acyltransferase 5 {ECO:0000256|ARBA:ARBA00039721};
DE EC=2.3.1.23 {ECO:0000256|ARBA:ARBA00026120};
DE EC=2.3.1.n6 {ECO:0000256|ARBA:ARBA00038923};
GN Name=LPCAT3 {ECO:0000313|Ensembl:ENSACCP00020018452.1};
OS Aquila chrysaetos chrysaetos.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae;
OC Accipitriformes; Accipitridae; Accipitrinae; Aquila.
OX NCBI_TaxID=223781 {ECO:0000313|Ensembl:ENSACCP00020018452.1, ECO:0000313|Proteomes:UP000472275};
RN [1] {ECO:0000313|Ensembl:ENSACCP00020018452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSACCP00020018452.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; phospholipid metabolism.
CC {ECO:0000256|ARBA:ARBA00005074}.
CC -!- PATHWAY: Phospholipid metabolism. {ECO:0000256|ARBA:ARBA00025707}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
CC -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010323}.
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DR AlphaFoldDB; A0A663F1T5; -.
DR Ensembl; ENSACCT00020019268.1; ENSACCP00020018452.1; ENSACCG00020012705.1.
DR GeneTree; ENSGT01030000234564; -.
DR InParanoid; A0A663F1T5; -.
DR Proteomes; UP000472275; Chromosome 7.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0106262; F:1-acylglycerophosphoethanolamine O-acyltransferase activity; IEA:Ensembl.
DR GO; GO:0106263; F:1-acylglycerophosphoserine O-acyltransferase activity; IEA:Ensembl.
DR GO; GO:0071617; F:lysophospholipid acyltransferase activity; IEA:TreeGrafter.
DR GO; GO:0034378; P:chylomicron assembly; IEA:Ensembl.
DR GO; GO:0090158; P:endoplasmic reticulum membrane organization; IEA:Ensembl.
DR GO; GO:0036335; P:intestinal stem cell homeostasis; IEA:Ensembl.
DR GO; GO:0030258; P:lipid modification; IEA:TreeGrafter.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:1903573; P:negative regulation of response to endoplasmic reticulum stress; IEA:Ensembl.
DR GO; GO:0036151; P:phosphatidylcholine acyl-chain remodeling; IEA:Ensembl.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:TreeGrafter.
DR GO; GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; IEA:Ensembl.
DR GO; GO:0036150; P:phosphatidylserine acyl-chain remodeling; IEA:Ensembl.
DR GO; GO:0045797; P:positive regulation of intestinal cholesterol absorption; IEA:Ensembl.
DR GO; GO:1905885; P:positive regulation of triglyceride transport; IEA:Ensembl.
DR GO; GO:0045540; P:regulation of cholesterol biosynthetic process; IEA:Ensembl.
DR GO; GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Ensembl.
DR InterPro; IPR049941; LPLAT_7/PORCN-like.
DR InterPro; IPR004299; MBOAT_fam.
DR PANTHER; PTHR13906:SF14; LYSOPHOSPHOLIPID ACYLTRANSFERASE 5; 1.
DR PANTHER; PTHR13906; PORCUPINE; 1.
DR Pfam; PF03062; MBOAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000472275};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 520 AA; 60117 MW; D0339BA94632465E CRC64;
MAVAGSGWGL AQLAEALGSS EQALRLIVSI LMGYPFALFQ RYFLFQKETY LIHLYNVFTG
LSIAYFNFGM QFFHSLLCVL IQFLILRLMG RTITAVFTTF FFQMVKLSFL LHRFVERSPL
FSFALPSSNC GWKSGDRSKP AGRISLNNTN NDFFQTYLMA GYYFTATEHY DIKWTMPHCV
LTLKLIGLAI DYYDGGKDPE FLTPEQRRFA VRGVPTLLEV SGFSYFYGAF MVGPQFSMTD
YQKLARCEMT DVQGQRPNSF VPALKRLSLG LLFLVTYTLS SLYVSDEYLI SDDYMEKPFW
FRCGYILIWG KIILYKYVTC WLVTEGVCIL VGLGYNGKDQ SGKPLWDACA NMKVWLYETT
PLFTGTIASF NINTNAWVAR YIFKRLKFLG NKLLSQALAL FFLAIWHGLH SGYLVCFQME
LLIVIVERQV INLVRDSPPL STLASITALR PIFYVLQQTN HWMFMGYSLV PFCLFTWDKW
MKVYRSIYFF GHVLFLTLLL VLPYIRRLVV PRKEKLKKAE
//
