ID A0A667ZXI7_9TELE Unreviewed; 1504 AA.
AC A0A667ZXI7;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE SubName: Full=Intersectin 2b {ECO:0000313|Ensembl:ENSMMDP00005047455.1};
GN Name=ITSN2 {ECO:0000313|Ensembl:ENSMMDP00005047455.1};
GN Synonyms=itsn2b {ECO:0000313|Ensembl:ENSMMDP00005047455.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005047455.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005047455.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMMDP00005047455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSMMDP00005047455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection {ECO:0000256|ARBA:ARBA00004316}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR Ensembl; ENSMMDT00005048398.1; ENSMMDP00005047455.1; ENSMMDG00005020680.1.
DR GeneTree; ENSGT00940000155936; -.
DR Proteomes; UP000472263; Chromosome 3.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:TreeGrafter.
DR CDD; cd08375; C2_Intersectin; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11994; SH3_Intersectin2_4; 1.
DR CDD; cd11996; SH3_Intersectin2_5; 1.
DR CDD; cd11838; SH3_Intersectin_3; 1.
DR FunFam; 1.20.900.10:FF:000011; Intersectin 1; 1.
DR FunFam; 2.30.30.40:FF:000041; Intersectin 1; 1.
DR FunFam; 2.60.40.150:FF:000029; Intersectin 1; 1.
DR FunFam; 1.10.238.10:FF:000055; Intersectin-1 isoform 1; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR051480; Endocytic_GEF_Adapter.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR035740; Intersectin-2_SH3_4.
DR InterPro; IPR035741; Intersectin-2_SH3_5.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF6; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EH; 2.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 2.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50002; SH3; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 17..105
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 49..84
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 244..333
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 277..312
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 737..798
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 836..894
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 910..974
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 984..1043
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1067..1253
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1362..1478
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 364..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1504 AA; 172722 MW; F1BDD411A8A16C2F CRC64;
LNFFFSGPSV WAISPEERDK HDLKFDTLTP SMGYVSGEQA RKFFLQSGLP ASVLAEIWAL
ADMNKDGKMD RLEFSIAMKL IKLKLQGTPL PSALPIIMKQ PPVSVPSLNL LCVSPPGMGS
MPNLSMLPGT NVAMLTPISM TTPGLSPMTP MSTLTPLVPT ATGLSPLIGS TPTRPLMPTM
GNAALPNGNL GILQPMLAGP LWFVHYIANP LKVWSLSFSS NSSSPSMLSP KPAGPSDWAV
PQASRLKYRQ QFNTLDKQMT GYLTGQQVRG AMATTMLTQT QLASIWTLAD VDKDGKLKAE
EFILAMHLVD MAKSGQPLPL TLPNELVPPS QRYVALKMHD KFKANLERGN AELEKRRQAL
LEAQRREEER RAQKEREERE RREREAREAE ERRRKEEERR LERQRELERQ KEEERQREIE
RKEAAQRELE RQRKEELERR RRGELQIKRE QEQDDIIQLK AKKRSLEMEL EAVGNKHRQI
SERLRDTQAR KKVQKTELDL TNQRKETRRQ DIDKLQRQLE EFQRKLSQLT PEQKRLQEKL
KNMTLNNLPA STMSTLKLNV IEKNGSCRKL REQLEALEKE TAAKLAEMDQ YNKDIQELRE
SQRKQQAALE KLRSIKEDKR RELNRRREQE EERKRQEEER KRIKLEKERQ WQEKLKRDEE
ERQRKLQEER EAKLREEEER EVQARLQAAR ELAERERKAK EAAERKRREE EERQRAEERR
RQEEERRQLE EERRKSAALT SFRALYPFTA RNQDELSFSA DDIIEVDETT EREQGWLYGS
RQGKMGWFPE SYVERMNTSD TANQTPAASA PKVALKPQLS NASTVHNSLE ASADGHQLEE
YVALYTYESP EPGDLTFGEG DVILVSQKEG EWWNGSIGDR TGLFPSNYVK PKETDTSSIT
GKKKPGKLPS LSLIAQVTSS YSSTGAEQLN LAPGQLILIL SKNTSGWWLG ELQARGKKRQ
KGWFPASHVK ILGSSSGKST PAPQPVCQVI AMYDYTAAND DEMSFSKGQL INVLDKNNPD
WWKGEVNGVT GLFPTNYVKM TTAESDPSQQ WCADLTSLDS LSPQERKRQG YIHELIQTED
RYVEDLQIVL EVFHKPMSES GRLTEAEMSM IFVNWKELIA CNTKLLKALR VRKKTGGENM
PVHVIGDILA AELAHMQPYI RFCSCQINGA ALLQTRTDSQ PEFKEFLKKI ATDYRCKGMP
LSSFLLKPMQ RITRYPLHIK NILECTAEGH VDRGPLKEAL ERAEELCQQV NEGVREKENS
DRLEWIQTHV QCEGVTENLV FNSLTNCLGP RKLLHSGKVR RVPVFLNEVL VKLPDPSSDE
PVFHISHIDR VYILKTENIN ERTAWVQKIK AASEDFIETE KKKREKAYQA RSMKASGIGR
LLVTILEATE LKACKPNGKS NPYCEVTMGA QIYTSRTLND TLNPKWNFNC QFHIKDIYQD
VLCITIFERD QFAPDDFLGR TEVPVATIKK ELENKGAATR RLLLHEVPTG EVWVRLDLQL
FNSK
//
