ID A0A668AA33_9TELE Unreviewed; 208 AA.
AC A0A668AA33;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=Reticulon {ECO:0000256|RuleBase:RU210713};
GN Name=RTN1 {ECO:0000313|Ensembl:ENSMMDP00005051650.1};
GN Synonyms=rtn1a {ECO:0000313|Ensembl:ENSMMDP00005051650.1};
OS Myripristis murdjan (pinecone soldierfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Holocentriformes; Holocentridae; Myripristis.
OX NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005051650.1, ECO:0000313|Proteomes:UP000472263};
RN [1] {ECO:0000313|Ensembl:ENSMMDP00005051650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMMDP00005051650.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSMMDP00005051650.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU210713}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU210713}.
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DR RefSeq; XP_029900945.1; XM_030045085.1.
DR AlphaFoldDB; A0A668AA33; -.
DR Ensembl; ENSMMDT00005052662.1; ENSMMDP00005051650.1; ENSMMDG00005023280.1.
DR GeneID; 115354649; -.
DR GeneTree; ENSGT00940000155077; -.
DR Proteomes; UP000472263; Chromosome 22.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0014069; C:postsynaptic density; IEA:TreeGrafter.
DR GO; GO:0007420; P:brain development; IEA:TreeGrafter.
DR GO; GO:0071787; P:endoplasmic reticulum tubular network formation; IEA:TreeGrafter.
DR GO; GO:0030182; P:neuron differentiation; IEA:TreeGrafter.
DR FunFam; 1.20.5.2480:FF:000001; Reticulon; 1.
DR Gene3D; 1.20.5.2480; -; 1.
DR InterPro; IPR003388; Reticulon.
DR InterPro; IPR046964; RTN1-4.
DR PANTHER; PTHR45799:SF6; RETICULON; 1.
DR PANTHER; PTHR45799; RETICULON-LIKE PROTEIN; 1.
DR Pfam; PF02453; Reticulon; 1.
DR PROSITE; PS50845; RETICULON; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU210713};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU210713};
KW Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU210713};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU210713}.
FT TRANSMEM 35..64
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU210713"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU210713"
FT DOMAIN 21..208
FT /note="Reticulon"
FT /evidence="ECO:0000259|PROSITE:PS50845"
SQ SEQUENCE 208 AA; 23309 MW; A0B7FE892F52C3A4 CRC64;
MQATADVTKK ECSWSSWKGQ AIDLLYWRNV KQSGAVFGSV LLLLFSLTQF SVVSVGAYLA
LAALSATISF RIYKSVLQAV QKTDEGHPFK AYLEVEIALS QDQISKYADK ILLYTNTCMK
ELRRLFLVQD LVDSLKFAVL MWLLTYVGAL FNGLTLLILA VVSMFTMPVV YEKHQAQIDQ
YVGLIRTQVN SVVGKIQAKI PGAKRKEE
//
