ID   A0A668ADV0_9TELE        Unreviewed;       733 AA.
AC   A0A668ADV0;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   28-JAN-2026, entry version 24.
DE   SubName: Full=Argonaute RISC component 1 {ECO:0000313|Ensembl:ENSMMDP00005046094.1};
GN   Name=AGO1 {ECO:0000313|Ensembl:ENSMMDP00005046094.1};
GN   Synonyms=ago1 {ECO:0000313|Ensembl:ENSMMDP00005046094.1};
OS   Myripristis murdjan (pinecone soldierfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Holocentriformes; Holocentridae; Myripristis.
OX   NCBI_TaxID=586833 {ECO:0000313|Ensembl:ENSMMDP00005046094.1, ECO:0000313|Proteomes:UP000472263};
RN   [1] {ECO:0000313|Ensembl:ENSMMDP00005046094.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Wellcome Sanger Institute Data Sharing;
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMMDP00005046094.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSMMDP00005046094.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000256|ARBA:ARBA00008201}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A668ADV0; -.
DR   Ensembl; ENSMMDT00005047013.1; ENSMMDP00005046094.1; ENSMMDG00005019216.1.
DR   GeneTree; ENSGT00940000158568; -.
DR   Proteomes; UP000472263; Chromosome 16.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR   CDD; cd02846; PAZ_argonaute_like; 1.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   FunFam; 2.170.260.10:FF:000001; Protein argonaute-2; 1.
DR   FunFam; 3.30.420.10:FF:000001; Protein argonaute-2; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.170.260.10; paz domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032473; Argonaute_Mid_dom.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16487; ArgoMid; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; PAZ domain; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472263};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT   DOMAIN          218..337
FT                   /note="PAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50821"
FT   DOMAIN          419..692
FT                   /note="Piwi"
FT                   /evidence="ECO:0000259|PROSITE:PS50822"
SQ   SEQUENCE   733 AA;  83664 MW;  0E29A4084891D9CC CRC64;
     MGAFPPPLQQ VFQAPRRPGM GTVGKPIKLL ANYFEVEIPK MDVYHYEVDI KPDKCPRRVN
     REVVEYMVQH FKPQLFGDRK PVYDGKKNIY TVLALPIGSE KVDFEVTIPG EGKDRIFKVS
     IRWLAKVSWR LLQETLVSGR LQVPLDSVQA LDVAMRHLAS MRYTPVGRSF FSPPEGYYHP
     LGGGREVWFG FHQSVRPAMW KMMLNIDVSA TAFYKAQPVI EFMCEVLDIR NIDEQPKTLT
     DSQRVRFTKE IKGLKVEVTH CGQMKRKYRV CNVTRRPASH QTFPLQLESG QTVECTVAQY
     FKQKYNLQLK YPHLPCLQVG QEQKHTYLPL EVCNIVAGQR CIKKLTDNQT STMIKATARS
     APDRQEEISR LNRAIATPNQ GVWDMRGKQF YNGIEIKVWA IACFAPQKQC REEVLNGGEC
     VQVKNVVKTS PQTLSNLCLK INVKLGGINN ILVPHQRSAV FQQPVIFLGA DVTHPPAGDG
     KKPSITAVVG SMDAHPSRYC ATVRVQRPRQ EIIEDLSYMV RELLIQFYKS TRFKPTRIIF
     YRDGVPEGQL PQILHYELLA IRDACIKLEK DYQPGITYIV VQKRHHTRLF CADKSERIGK
     SGNIPAGTTV DTSITHPFEF DFYLCSHAGI QGTSRPSHYY VLWDDNRFTA DELQILTYQL
     CHTYVRCTRS VSIPAPAYYA RLVAFRARYH LVDKEHDSGE GSHVSGQSNG RDPQALAKAV
     QIHHDTLRTM YFA
//