ID A0A668UQ28_OREAU Unreviewed; 230 AA.
AC A0A668UQ28;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Platelet-derived growth factor subunit A {ECO:0000256|ARBA:ARBA00040278};
DE AltName: Full=Platelet-derived growth factor A chain {ECO:0000256|ARBA:ARBA00042479};
DE AltName: Full=Platelet-derived growth factor alpha polypeptide {ECO:0000256|ARBA:ARBA00041285};
GN Name=PDGFA {ECO:0000313|Ensembl:ENSOABP00000042075.1};
OS Oreochromis aureus (Israeli tilapia) (Chromis aureus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=47969 {ECO:0000313|Ensembl:ENSOABP00000042075.1, ECO:0000313|Proteomes:UP000472276};
RN [1] {ECO:0000313|Ensembl:ENSOABP00000042075.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSOABP00000042075.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686, ECO:0000256|RuleBase:RU003818}.
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DR AlphaFoldDB; A0A668UQ28; -.
DR Ensembl; ENSOABT00000043200.2; ENSOABP00000042075.1; ENSOABG00000019009.2.
DR OMA; NSEYREH; -.
DR Proteomes; UP000472276; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005161; F:platelet-derived growth factor receptor binding; IEA:TreeGrafter.
DR GO; GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:TreeGrafter.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:TreeGrafter.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:TreeGrafter.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:TreeGrafter.
DR CDD; cd00135; PDGF; 1.
DR FunFam; 2.10.90.10:FF:000017; Platelet derived growth factor subunit A; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR006782; PDGF_N.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF3; PLATELET-DERIVED GROWTH FACTOR SUBUNIT A; 1.
DR Pfam; PF00341; PDGF; 1.
DR Pfam; PF04692; PDGF_N; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU003818}; Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000472276};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..230
FT /note="Platelet-derived growth factor subunit A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025475625"
FT DOMAIN 96..197
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 197..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..230
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 230 AA; 26831 MW; BAD570A6E80D3B56 CRC64;
MRATLSYILL WTTYLLATAE EVEFPQELID RLSHSEIHSI SDLQRLLDID WRGTGNDVIE
EPKHQKHHKH PNHHKNSSHH YGYYGDLKSS QLHSRRKRSI VEEAVPAVCK TRTVIYEIPR
SQVDPTSANF LIWPPCVEVK RCTGCCNTSN MRCHPSRKHH RTVKVAKVEY VRRRPKLKEV
FVRLEDHLEC VCTSHHHAVE PSDPETGHRR AKGKKRKPKK LRRTKGLLVT
//
