ID A0A670IZL0_PODMU Unreviewed; 1254 AA.
AC A0A670IZL0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Tetratricopeptide repeat domain 21A {ECO:0000313|Ensembl:ENSPMRP00000017251.1};
GN Name=TTC21A {ECO:0000313|Ensembl:ENSPMRP00000017251.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000017251.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000017251.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000017251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPMRP00000017251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TTC21 family.
CC {ECO:0000256|ARBA:ARBA00010935}.
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DR AlphaFoldDB; A0A670IZL0; -.
DR Ensembl; ENSPMRT00000018368.1; ENSPMRP00000017251.1; ENSPMRG00000010937.1.
DR GeneTree; ENSGT00390000005979; -.
DR Proteomes; UP000472272; Chromosome 12.
DR GO; GO:0005929; C:cilium; IEA:GOC.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:TreeGrafter.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:TreeGrafter.
DR GO; GO:0061512; P:protein localization to cilium; IEA:TreeGrafter.
DR FunFam; 1.25.40.10:FF:000279; Tetratricopeptide repeat domain 21A; 1.
DR FunFam; 1.25.40.10:FF:000197; Tetratricopeptide repeat domain 21B; 1.
DR FunFam; 1.25.40.10:FF:000219; Tetratricopeptide repeat domain 21B; 1.
DR FunFam; 1.25.40.10:FF:000493; Tetratricopeptide repeat domain 21B; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 6.
DR InterPro; IPR056832; ARM_TT21_2nd.
DR InterPro; IPR056836; ARM_TT21_4th.
DR InterPro; IPR056835; ARM_TT21_5th.
DR InterPro; IPR056834; ARM_TT21_C.
DR InterPro; IPR056833; ARM_TT21_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_rpt.
DR InterPro; IPR040364; TTC21A/TTC21B.
DR PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR PANTHER; PTHR14699:SF2; TETRATRICOPEPTIDE REPEAT PROTEIN 21A; 1.
DR Pfam; PF25058; ARM_TT21; 1.
DR Pfam; PF25060; ARM_TT21_2nd; 1.
DR Pfam; PF25068; ARM_TT21_4th; 2.
DR Pfam; PF25064; ARM_TT21_5th; 1.
DR Pfam; PF25063; ARM_TT21_C; 1.
DR Pfam; PF25062; ARM_TT21_N; 1.
DR Pfam; PF13176; TPR_7; 1.
DR SMART; SM00028; TPR; 14.
DR SUPFAM; SSF48452; TPR-like; 6.
DR PROSITE; PS50005; TPR; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT DOMAIN 12..231
FT /note="Tetratricopeptide repeat protein 21A/21B N-terminal
FT ARM repeat"
FT /evidence="ECO:0000259|Pfam:PF25062"
FT DOMAIN 252..524
FT /note="Tetratricopeptide repeat protein 21A/21B second ARM"
FT /evidence="ECO:0000259|Pfam:PF25060"
FT REPEAT 476..509
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 702..735
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 736..769
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 738..800
FT /note="Tetratricopeptide repeat protein 21A/21B fourth ARM"
FT /evidence="ECO:0000259|Pfam:PF25068"
FT DOMAIN 805..860
FT /note="Tetratricopeptide repeat protein 21A/21B fourth ARM"
FT /evidence="ECO:0000259|Pfam:PF25068"
FT REPEAT 901..934
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 903..1017
FT /note="Tetratricopeptide repeat protein 21A/21B fifth ARM
FT repeats"
FT /evidence="ECO:0000259|Pfam:PF25064"
FT DOMAIN 1048..1249
FT /note="Tetratricopeptide repeat protein 21A/21B C-terminal
FT ARM"
FT /evidence="ECO:0000259|Pfam:PF25063"
FT COILED 352..379
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1254 AA; 143165 MW; 6B3A7F7B803619F1 CRC64;
MIFSFSPLKA KILYYAQEKY FNYVVQVTNI ELAKHANDPV LFQLYYILAG RIQEGIVLLE
NARKRHVDVS LCCLLGLIYA HKRCENVDTS ALLDLETKLK EARKTAGSNA LYYAGMFLWL
LNKNDKAKEY VDRMLKVSNG AREGLVLKGW IYVTSDKAHA AKKAIKYLDE GIQDNTEIFG
MMGKAKYFMV QQNYSGALEI ISQLVVTYPL FTPAIVIKMR LHLASQDWEQ TAEESKRVSD
FKILNFLMQA LQMLREFIVA LELKEPQRSE LHLQKILVIS RLCGKNQNIL REVYEFVKDS
GSNLISSNAH YANELGYLLI LQGCWKEASE WYAKASELNE NTADSMTGSI WCQVLGGKIE
EAENQLEFLK EVQQSTGKSS LLAYLQGVIA SRKNNDQAAC AFLNEAAELH CSALHGLPLS
IEYYEKLNPM FMIEIVKEYL VFCPKQPRLP GQVLSSLLKQ VTIILNPLVK ATPGMIEPLY
LMAQVKYLSG ELETAQGTLQ RCLELDPTST DANLLKAQIH LSQGNIKECV HSLEIGVSYN
FQLRDSPWYH FIRARALNKA GEYPEAIKVL KMLISLPQMK GEAKKGQGPR IVISEQVSIY
LELAEALRFN GELHEATKVM QDAIIEFNGT SEETRVMVAN VDLALSKGEI DSALTMLRNV
TPCQPYYTEV KEKMAQIYLQ VRKDKRLYIG CYCELCENMP SPHTSLLLGD AYMNIQEPEK
ALEVYEAAQK KNPLDATVAR KIGKAFVSTH QYNKAVNYYE VALKMSEQDF LCHDLADLLL
KLKKFGKAEK VLNQALDHDP VVLILAYDIQ QRILKRVRVE QPELIPSQKQ VLLMICVQFA
KFHQAEKEYE KALKYYTEAL SCVPTDSKIM LELAQLYLMQ EDTEQCEHYC TLLLQDDESN
EIGTMMMANL MFRKEAYEEA ISLYRNVLEK SPDNFLVMEN LIDLLRRSGK LDEATHFFEL
AKRKSSRTAL DPGYNYCMGL YCWHMMQPNQ ALKFFNKARK DSDWGQKALG HMIQICLNPD
NDIIDPDVGK DGGNLKEKKE SEQHGIRTAE KLLKEFYPHS QEGQNQVEML QSYCLMATRE
THNVEKALKV FTEIVSAVLA VSQAYMLLKQ PLKARNQLKR LMKAKWSLTE AEDLEKCWIL
LADSYTACGK FDCAIELVKR CLRHNKSCSK AYECLGYIAE KEKAYKDAAA NYELAWKHSH
QANPTVGFKL AFNYLKDKRY VEAIDVCHDV LKACPEYPKI REEILEKAQT AIKP
//
