ID A0A670JHB1_PODMU Unreviewed; 211 AA.
AC A0A670JHB1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Snake venom vascular endothelial growth factor toxin HF-like {ECO:0000313|Ensembl:ENSPMRP00000023004.1};
GN Name=LOC114603133 {ECO:0000313|Ensembl:ENSPMRP00000023004.1};
OS Podarcis muralis (Wall lizard) (Lacerta muralis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Laterata;
OC Lacertibaenia; Lacertidae; Podarcis.
OX NCBI_TaxID=64176 {ECO:0000313|Ensembl:ENSPMRP00000023004.1, ECO:0000313|Proteomes:UP000472272};
RN [1] {ECO:0000313|Ensembl:ENSPMRP00000023004.1, ECO:0000313|Proteomes:UP000472272}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30819892; DOI=10.1073/pnas.1820320116;
RA Andrade P., Pinho C., Perez I de Lanuza G., Afonso S., Brejcha J.,
RA Rubin C.J., Wallerman O., Pereira P., Sabatino S.J., Bellati A.,
RA Pellitteri-Rosa D., Bosakova Z., Bunikis I., Carretero M.A., Feiner N.,
RA Marsik P., Pauperio F., Salvi D., Soler L., While G.M., Uller T., Font E.,
RA Andersson L., Carneiro M.;
RT "Regulatory changes in pterin and carotenoid genes underlie balanced color
RT polymorphisms in the wall lizard.";
RL Proc. Natl. Acad. Sci. U.S.A. 116:5633-5642(2019).
RN [2] {ECO:0000313|Ensembl:ENSPMRP00000023004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSPMRP00000023004.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|RuleBase:RU003818}.
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DR RefSeq; XP_028597744.1; XM_028741911.1.
DR AlphaFoldDB; A0A670JHB1; -.
DR Ensembl; ENSPMRT00000024432.1; ENSPMRP00000023004.1; ENSPMRG00000014936.1.
DR GeneID; 114603133; -.
DR KEGG; pmua:114603133; -.
DR GeneTree; ENSGT00940000160164; -.
DR OMA; ECRHVAS; -.
DR OrthoDB; 6370328at2759; -.
DR Proteomes; UP000472272; Chromosome 8.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IEA:TreeGrafter.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IEA:TreeGrafter.
DR GO; GO:0050930; P:induction of positive chemotaxis; IEA:TreeGrafter.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:TreeGrafter.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:TreeGrafter.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:TreeGrafter.
DR GO; GO:0001666; P:response to hypoxia; IEA:TreeGrafter.
DR GO; GO:0002040; P:sprouting angiogenesis; IEA:TreeGrafter.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:TreeGrafter.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:TreeGrafter.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR050507; PDGF/VEGF_growth_factor.
DR PANTHER; PTHR12025; VASCULAR ENDOTHELIAL GROWTH FACTOR; 1.
DR PANTHER; PTHR12025:SF15; VASCULAR ENDOTHELIAL GROWTH FACTOR C-LIKE ISOFORM X1; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU003818};
KW Reference proteome {ECO:0000313|Proteomes:UP000472272}.
FT DOMAIN 55..152
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
FT REGION 152..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 211 AA; 23649 MW; 834CFEFBB36C9422 CRC64;
MPSSADSGAG RAWTSLLQHR SSSRSRTKRM PVPGYLVAIA LLCAQPVLTS EQPAGVVPFE
EVWSRSYCRA RETLVDILSE FPHEAEHIFK PPCVPLWRCA GCCGDESLEC IAVETRTIDL
QVVRVSPILG TTQQEEMKFV EHTRCSCRPR RKRLKGERSH RIGAKRRPRE PSLTPFTPLS
CKLPGAGRPE AQHRDQEEAT NLPLSERDVP L
//
