ID A0A671E0A9_RHIFE Unreviewed; 912 AA.
AC A0A671E0A9;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=Exocyst complex component 1 {ECO:0000256|ARBA:ARBA00068988};
DE AltName: Full=Exocyst complex component Sec3 {ECO:0000256|ARBA:ARBA00079611};
GN Name=EXOC1 {ECO:0000313|Ensembl:ENSRFEP00010006636.1};
OS Rhinolophus ferrumequinum (Greater horseshoe bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea;
OC Rhinolophidae; Rhinolophinae; Rhinolophus.
OX NCBI_TaxID=59479 {ECO:0000313|Ensembl:ENSRFEP00010006636.1, ECO:0000313|Proteomes:UP000472240};
RN [1] {ECO:0000313|Ensembl:ENSRFEP00010006636.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25689317; DOI=10.1146/annurev-animal-090414-014900;
RA Koepfli K.P., Paten B., O'Brien S.J., Koepfli K.P., Paten B., Antunes A.,
RA Belov K., Bustamante C., Castoe T.A., Clawson H., Crawford A.J.,
RA Diekhans M., Distel D., Durbin R., Earl D., Fujita M.K., Gamble T.,
RA Georges A., Gemmell N., Gilbert M.T., Graves J.M., Green R.E., Hickey G.,
RA Jarvis E.D., Johnson W., Komissarov A., Korf I., Kuhn R., Larkin D.M.,
RA Lewin H., Lopez J.V., Ma J., Marques-Bonet T., Miller W., Murphy R.,
RA Pevzner P., Shapiro B., Steiner C., Tamazian G., Venkatesh B., Wang J.,
RA Wayne R., Wiley E., Yang H., Zhang G., Haussler D., Ryder O., O'Brien S.J.;
RT "The Genome 10K Project: a way forward.";
RL Annu Rev Anim Biosci 3:57-111(2015).
RN [2] {ECO:0000313|Ensembl:ENSRFEP00010006636.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29166127; DOI=10.1146/annurev-animal-022516-022811;
RA Teeling E.C., Vernes S.C., Davalos L.M., Ray D.A., Gilbert M.T.P.,
RA Myers E.;
RT "Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level
RT Genomes for All Living Bat Species.";
RL Annu Rev Anim Biosci 6:23-46(2018).
RN [3] {ECO:0000313|Ensembl:ENSRFEP00010006636.1, ECO:0000313|Proteomes:UP000472240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Teeling E., Myers G., Vernes S., Pippel M., Winkler S., Fedrigo O.,
RA Rhie A., Koren S., Phillippy A., Lewin H., Damas J., Howe K.,
RA Mountcastle J., Jarvis E.D.;
RT "G10K-VGP greater horseshoe bat female genome, primary haplotype.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSRFEP00010006636.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|ARBA:ARBA00002660}.
CC -!- SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4,
CC EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EEF1A1. Interacts with
CC SLC6A9; interaction increases the transporter capacity of SLC6A9
CC probably by promoting its insertion into the cell membrane.
CC {ECO:0000256|ARBA:ARBA00061758}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm, perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Midbody,
CC Midbody ring {ECO:0000256|ARBA:ARBA00004476}.
CC -!- SIMILARITY: Belongs to the SEC3 family.
CC {ECO:0000256|ARBA:ARBA00006518}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_032962164.1; XM_033106273.1.
DR AlphaFoldDB; A0A671E0A9; -.
DR Ensembl; ENSRFET00010007270.1; ENSRFEP00010006636.1; ENSRFEG00010004491.1.
DR GeneID; 117022292; -.
DR GeneTree; ENSGT00940000158640; -.
DR Proteomes; UP000472240; Chromosome 5.
DR GO; GO:0000145; C:exocyst; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IEA:TreeGrafter.
DR CDD; cd14683; PH-EXOC1; 1.
DR FunFam; 2.30.29.90:FF:000001; exocyst complex component 1 isoform X1; 1.
DR Gene3D; 2.30.29.90; -; 1.
DR InterPro; IPR028258; Sec3-PIP2_bind.
DR InterPro; IPR048628; Sec3_C.
DR InterPro; IPR019160; Sec3_CC.
DR PANTHER; PTHR16092:SF33; EXOCYST COMPLEX COMPONENT 1; 1.
DR PANTHER; PTHR16092; SEC3/SYNTAXIN-RELATED; 1.
DR Pfam; PF15277; Sec3-PIP2_bind; 1.
DR Pfam; PF20654; Sec3_C-term; 1.
DR Pfam; PF09763; Sec3_CC; 1.
DR SMART; SM01313; Sec3-PIP2_bind; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000472240};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 31..122
FT /note="Exocyst complex component Sec3 PIP2-binding N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM01313"
FT REGION 458..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 207..255
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 458..477
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..509
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 104192 MW; BCD42C9D06564823 CRC64;
MTAIKHALQR DIFTPNDERL LSIVNVCKAG KKKKNCFLCA TVTTERPVQV KVVKVKKSDK
GDFYKRQIAW ALRDLAVVDA KDAIKENPEF DLHFEKIYKW VASSTAEKNA FISCIWKLNQ
RYLRKKIDFV NVSSQLLEES VPSGENQSVT GGDEEAVDEY QELNAREEQD IEIMMEGCEY
AISNAEAFAE RLSRELQVLD GANIQSIMAS EKQVNILMKL LDEALKEVDQ IELKLSSYEE
MLQSVKEQMD QISESNHLIH LSNTNNVKLL SEIEFLVNHM DLAKGHIKAL QEGDLASSRG
IEACTNAADA LLQCMNVALR PGHDMLLAVR QQQQRFSDLR EHFARRLASH LNNVFVQQFT
QALLQLYNRS YFLSVPGHDQ SSTLAQHSVE LTLPNHHPFH RDLLRYAKLM EWLKNTDYGK
YEGLTKNYMD YLSRLYEREI KDFFEVAKIK MTGTTKESKK FATLPRKESA VKQETESLHG
SSGKLTGSTS SLNKLSVQSS GNRRSQSSSL LDMGNMSASD LDVADRTKFD KIFEQVLSEL
EPLCLAEQDF ISKFFKLQQH QSMPGTMTEA DDLDGGTLSR PHNSGTPLPV SSEKDMIRQM
MTKIFRCIEP ELNNLIALGD KIDSFNSLYM LVKMSHHVWT AQNVDPASFL STTLGNVLVT
IKRNFDKCIS NQIRQMEEVK ISKKSKVGIL PFVAEFEEFA GLAESIFKNA ERRGDLDKAY
TKLIRGVFVN VEKVANESQK TPRDVVMMEN FHHIFATLSR LKISCLEAEK KEAKQKYTDH
LQSYVIYSLG QPLEKLNHFF EGVEARVAQG IREEEVSYQL AFNKQELRKV IKEYPGKEVK
KGLDNLYKKV DKHLCEEENL LQVVWHSMQD EFIRQYKHFE GLIARCYPGS GVTMEFTIQD
ILDYCSSIAQ SH
//
