ID A0A671P6M5_9TELE Unreviewed; 498 AA.
AC A0A671P6M5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE RecName: Full=Ethanolamine kinase {ECO:0000256|ARBA:ARBA00081737};
DE EC=2.7.1.32 {ECO:0000256|ARBA:ARBA00066350};
DE EC=2.7.1.82 {ECO:0000256|ARBA:ARBA00038874};
GN Name=LOC107672263 {ECO:0000313|Ensembl:ENSSANP00000054382.1};
OS Sinocyclocheilus anshuiensis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Sinocyclocheilus.
OX NCBI_TaxID=1608454 {ECO:0000313|Ensembl:ENSSANP00000054382.1, ECO:0000313|Proteomes:UP000472260};
RN [1] {ECO:0000313|Ensembl:ENSSANP00000054382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSANP00000054382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=choline + ATP = phosphocholine + ADP + H(+);
CC Xref=Rhea:RHEA:12837, ChEBI:CHEBI:15354, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:295975, ChEBI:CHEBI:456216;
CC EC=2.7.1.32; Evidence={ECO:0000256|ARBA:ARBA00052454};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12838;
CC Evidence={ECO:0000256|ARBA:ARBA00052454};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ethanolamine + ATP = phosphoethanolamine + ADP + H(+);
CC Xref=Rhea:RHEA:13069, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57603, ChEBI:CHEBI:58190, ChEBI:CHEBI:456216;
CC EC=2.7.1.82; Evidence={ECO:0000256|ARBA:ARBA00050770};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13070;
CC Evidence={ECO:0000256|ARBA:ARBA00050770};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00037883}.
CC -!- SIMILARITY: Belongs to the choline/ethanolamine kinase family.
CC {ECO:0000256|ARBA:ARBA00038211}.
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DR AlphaFoldDB; A0A671P6M5; -.
DR Ensembl; ENSSANT00000057845.1; ENSSANP00000054382.1; ENSSANG00000027176.1.
DR Proteomes; UP000472260; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004103; F:choline kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004305; F:ethanolamine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:TreeGrafter.
DR CDD; cd05156; ChoK_euk; 1.
DR FunFam; 3.90.1200.10:FF:000005; Choline kinase alpha; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR Gene3D; 3.30.200.20; Phosphorylase Kinase, domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR PANTHER; PTHR22603:SF102; CHOLINE KINASE ALPHA; 1.
DR PANTHER; PTHR22603; CHOLINE/ETHANOALAMINE KINASE; 1.
DR Pfam; PF01633; Choline_kinase; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000472260};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 26..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 57497 MW; 118D54C4D6BB52D6 CRC64;
MLLQLKLIIS LPFNFFPALR KRTSQSCVKK HGEAKAVTRQ TLSSTPSSTS SSKRSQVNIS
SLPKRLESKP TQPLPEGRRR CRGVWTKSSS RVSASGNLME PSRRDTDRRG SGGKGSVAHP
SENNQIQPDS ENDCKDIIRP DVPDNQTKHK AYLWCKEFLH GAWKSIDEDD FQISIIRGGL
SNKLFLCALP EKQPSIGDEP RNVLLRLYGQ ILQGADAMVL ESVMFAILAE RELGPKLYGI
FPQGRLEQFV PSRKLSTDEL SVPGIFAEIA EKIARFHGMR MPFNKEPKWL FGTMEKYMDQ
VLQLTFTREH HLRNFSRLLS YNLPQEMDSL KCLLESTPSP VVFCHNDLQE GNILLLSGRE
NTDRQRLMLI DFEYSSYSYR GFDFGNFFCE WTYDYTYDKF PFFITNTKNY PTKAQQMHFF
QSYLLESHAG FENLNEDDQL KLKEDMLVEV NRFALASHFF WGLWSIIQAK ISTIEFGYME
YAMARFDAYF ELKKKLMV
//
