ID   A0A671TBK9_9TELE        Unreviewed;       556 AA.
AC   A0A671TBK9;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   28-JAN-2026, entry version 26.
DE   RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
GN   Name=foxj3 {ECO:0000313|Ensembl:ENSSANP00000107051.1};
OS   Sinocyclocheilus anshuiensis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Sinocyclocheilus.
OX   NCBI_TaxID=1608454 {ECO:0000313|Ensembl:ENSSANP00000107051.1, ECO:0000313|Proteomes:UP000472260};
RN   [1] {ECO:0000313|Ensembl:ENSSANP00000107051.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSSANP00000107051.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR   AlphaFoldDB; A0A671TBK9; -.
DR   Ensembl; ENSSANT00000113581.1; ENSSANP00000107051.1; ENSSANG00000052295.1.
DR   Proteomes; UP000472260; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR   CDD; cd20052; FH_FOXJ3; 1.
DR   FunFam; 1.10.10.10:FF:000088; Forkhead box protein J3; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001766; Fork_head_dom.
DR   InterPro; IPR045912; FOXJ2/3-like.
DR   InterPro; IPR018122; TF_fork_head_CS_1.
DR   InterPro; IPR030456; TF_fork_head_CS_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46078:SF2; FORK-HEAD DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46078; FORKHEAD BOX PROTEIN J2 FAMILY MEMBER; 1.
DR   Pfam; PF00250; Forkhead; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; 1.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00089};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000472260};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          62..157
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000259|PROSITE:PS50039"
FT   DNA_BIND        62..157
FT                   /note="Fork-head"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT   REGION          127..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          253..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..331
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..365
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..389
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   556 AA;  62035 MW;  846205B47E012B6D CRC64;
     MTSELESSLT SMDWLPQLTM RAAIQKADTQ NAHGPGMAKK SALLDPNTTL DQEEVQQHKD
     GKPPYSYASL ITFAINSSPK KKMTLSEIYQ WICDNFPYYR EAGSGWKNSI RHNLSLNKCF
     LKVPRSKDDP GKGSYWAIDT NPKEDTLPTR PKKRPRSGER ASTPYSLESD NLGMDCIISG
     SASPTLAINT VTNKVTSHPE SVSQSMSLQQ APQAQYNIPE RDKQLLFSDF EDLSASFRSL
     YKTVFEQSYN QQGLMGMPSE SSQQTHTSCS YQHSPSTTIS THPHNNQNSI TNSHPNNIPN
     SGSQVPLSHP PHSAHNSPHG QHLSQHGPHT QHSQHPHTAH SQHPQHSQHS QHGQHPSQHQ
     AHGQHTPQQQ HQNLSHQPHP AQQQMQCNTG LPSDWYPNLD ALKESCRIAS SYNWADVDLS
     PFQGLKESMR QAELNNWSLE PTQIADLCSS INQFFARTGI QPQGAVQPPV CHGSMHPKPN
     PHINTGNMYM DSRQSLSSMM GPPGYPHMPP MSSAGPTMTG HHAQMNQQHM MPAGNFQIRR
     MPADDIQDDF DWDSIV
//