ID A0A671X5M3_SPAAU Unreviewed; 665 AA.
AC A0A671X5M3;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 22.
DE SubName: Full=E74-like ETS transcription factor 1 {ECO:0000313|Ensembl:ENSSAUP00010046308.1};
GN Name=elf1 {ECO:0000313|Ensembl:ENSSAUP00010046308.1};
OS Sparus aurata (Gilthead sea bream).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Spariformes; Sparidae; Sparus.
OX NCBI_TaxID=8175 {ECO:0000313|Ensembl:ENSSAUP00010046308.1, ECO:0000313|Proteomes:UP000472265};
RN [1] {ECO:0000313|Ensembl:ENSSAUP00010046308.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (APR-2021) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSAUP00010046308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSSAUP00010046308.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR AlphaFoldDB; A0A671X5M3; -.
DR Ensembl; ENSSAUT00010048674.1; ENSSAUP00010046308.1; ENSSAUG00010019307.1.
DR GeneTree; ENSGT00940000157039; -.
DR InParanoid; A0A671X5M3; -.
DR OMA; CSYLFPT; -.
DR OrthoDB; 8196042at2759; -.
DR Proteomes; UP000472265; Chromosome 18.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProtKB-ARBA.
DR FunFam; 1.10.10.10:FF:000066; ETS-related transcription factor Elf-2 isoform X1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR022084; TF_Elf_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF170; ETS-RELATED TRANSCRIPTION FACTOR ELF-4; 1.
DR Pfam; PF12310; Elf-1_N; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004019};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000472265};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 222..304
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 172..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..196
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 71637 MW; 7ABEA1B55D6488AE CRC64;
MTTAVQPTEL VFEFASNGMD EINQVCSYFI PTPASESCGA GLILDDPSVF PAVIVEQVPA
ADLLQVYSGL ESDEVTNGIM VDTTLHVVEE PSILVGGVDL SETTVSGAED SMETNEAAAA
LLNMESPNNI LDEKRMIHSY GTLLESDLTY APLRPDQMDN GALDMSLDED TSSMDEIPQK
CPLKPQKKTK VRKPRAVRPC SPITTPNLPL RKKSKEGKGN TIYLWEFLLA LLQDKNTCPK
YIKWTQREKG IFKLVDSKAV SKLWGKHKNK PDMNYETMGR ALRYYYQRGI LAKVEGQRLV
YQFKEMPADL VVIEDEDAGS DGNGSYGNQR STNGRSMVRG GSKGHGRAHG QHQVSVKQMK
KEPSDEFLYG DDHGGQAELL QSVHMLQASQ EQAQAMRTIT APASVPMVLT SSGSLQSVPL
TTVLANGDSS HCSPPRVILH TVPSTTAGGK DVLTIQTASL AGGASSLQDG LPQQLLVTSL
GSSTVSTSSS CTSPRGVISS TASNLNGLPR LVTINTTCGQ TMVAQQPGTV IATVLKSGDL
SELQVKEELL DPSYFQSMVN GDPSLAANTF AKEEMEVGEA ELQYRTVIID TSQSQGQEAV
SESIINGHPS QSSSPSEGLT PVEELEVRGE MSLQSEQGIK GLQELPLSVQ LPANFIQIKT
EPAEA
//
