ID   A0A672SSA2_SINGR        Unreviewed;       677 AA.
AC   A0A672SSA2;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   28-JAN-2026, entry version 24.
DE   RecName: Full=WD repeat-containing protein 48 {ECO:0000256|ARBA:ARBA00021209};
DE   AltName: Full=USP1-associated factor 1 {ECO:0000256|ARBA:ARBA00031683};
GN   Name=wdr48b {ECO:0000313|Ensembl:ENSSGRP00000105090.1};
OS   Sinocyclocheilus grahami (Dianchi golden-line fish) (Barbus grahami).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Sinocyclocheilus.
OX   NCBI_TaxID=75366 {ECO:0000313|Ensembl:ENSSGRP00000105090.1, ECO:0000313|Proteomes:UP000472262};
RN   [1] {ECO:0000313|Ensembl:ENSSGRP00000105090.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSSGRP00000105090.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the WD repeat WDR48 family.
CC       {ECO:0000256|ARBA:ARBA00006917}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_016147546.1; XM_016292060.1.
DR   AlphaFoldDB; A0A672SSA2; -.
DR   Ensembl; ENSSGRT00000111721.1; ENSSGRP00000105090.1; ENSSGRG00000052036.1.
DR   GeneID; 107600221; -.
DR   CTD; 334682; -.
DR   OrthoDB; 2421129at2759; -.
DR   Proteomes; UP000472262; Unassembled WGS sequence.
DR   GO; GO:0043130; F:ubiquitin binding; IEA:TreeGrafter.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:TreeGrafter.
DR   CDD; cd17041; Ubl_WDR48; 1.
DR   CDD; cd00200; WD40; 1.
DR   FunFam; 2.130.10.10:FF:000054; Putative WD repeat-containing protein 48; 1.
DR   FunFam; 2.130.10.10:FF:000062; Putative WD repeat-containing protein 48; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR020472; WD40_PAC1.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR051246; WDR48.
DR   InterPro; IPR021772; WDR48/Bun107.
DR   PANTHER; PTHR19862; WD REPEAT-CONTAINING PROTEIN 48; 1.
DR   PANTHER; PTHR19862:SF14; WD REPEAT-CONTAINING PROTEIN 48; 1.
DR   Pfam; PF11816; DUF3337; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000472262};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          26..67
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          71..112
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          113..154
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          164..205
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          206..247
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   677 AA;  75967 MW;  658B950A93EA0DC1 CRC64;
     MATHHRQNAA ARRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIVRIWSVN
     QHKQDSYIAS MEHHTDWVND IILCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV
     KALAYAKDKE LVASAGLDRQ IFLWDVNTLT ALTASNNTVT TSSLSGNKDS IYSLAMNQTG
     TVIISGSTEK VLRVWDPRTC AKLMKLKGHT DNVKSLLLNR DGTQCLSGSS DGTIRLWSLG
     QQRCIATYRV HDEGVWALQV NEAFTHIYSG GRDRKIFCTD LRNPDLRVLI CEEKAPILKM
     ELDKSAEPPQ AIWVSTTKSF VNKWSLNGMH NFRASGDYDN DCSAPLTPLC TQPEQVIKGG
     TSIVQCHILN DKRHILTKDS NNSVAFCDVL KACKGEDLGK VDFDEEIKKR FKMVYVPNWF
     SVDLKTGMLT ITLDESDCFA AWVAAKDAGF TSPDGSDPKL NLGGLLLQAL LEFWPRTHIN
     PVEEEESELN HVNGEQESRI QKGNGYFQVP PHTPVIFGEA GGRTLFRLLC RDSGGETESM
     LLNETVPQWV IDITVVKNMP KFNKIPFYLQ PHSSSGAKTL KKDRLSASDM LQVRKVMEHV
     YEKIINLDTE SQTTSSSVND KPGEQEKEED VAVIAEEKIE LLCLDQVLDP NIDLRTVKHF
     IWKSGGDLTL HYRQKST
//