ID   A0A672ZSY6_9TELE        Unreviewed;       384 AA.
AC   A0A672ZSY6;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   28-JAN-2026, entry version 23.
DE   SubName: Full=Suppressor of cytokine signaling 4-like {ECO:0000313|Ensembl:ENSSORP00005020271.1};
GN   Name=LOC115437823 {ECO:0000313|Ensembl:ENSSORP00005020271.1};
GN   Synonyms=LOC115415312 {ECO:0000313|Ensembl:ENSSORP00005020281.1};
OS   Sphaeramia orbicularis (orbiculate cardinalfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX   NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005020271.1, ECO:0000313|Proteomes:UP000472271};
RN   [1] {ECO:0000313|Ensembl:ENSSORP00005020271.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Wellcome Sanger Institute Data Sharing;
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSORP00005020271.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2025) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
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DR   RefSeq; XP_030017036.1; XM_030161176.1.
DR   AlphaFoldDB; A0A672ZSY6; -.
DR   Ensembl; ENSSORT00005020842.1; ENSSORP00005020271.1; ENSSORG00005009888.1.
DR   Ensembl; ENSSORT00005020852.1; ENSSORP00005020281.1; ENSSORG00005009896.1.
DR   GeneID; 115437823; -.
DR   OrthoDB; 8820570at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000472271; Chromosome 3.
DR   GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter.
DR   GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR022252; SOCS4/SOCS5_dom.
DR   InterPro; IPR001496; SOCS_box.
DR   InterPro; IPR036036; SOCS_box-like_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF12610; SOCS; 1.
DR   Pfam; PF07525; SOCS_box; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00253; SOCS; 1.
DR   SMART; SM00969; SOCS_box; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF158235; SOCS box-like; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50225; SOCS; 1.
PE   4: Predicted;
KW   Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          238..333
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          328..377
FT                   /note="SOCS box"
FT                   /evidence="ECO:0000259|PROSITE:PS50225"
FT   REGION          26..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..189
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   384 AA;  43356 MW;  9538BC4F8498C961 CRC64;
     MSEKKPRGSD TRPKCSLRSW SADSYVWKGK KRSRSVRNSS SPGLEAEEDL GVRSTSCPRR
     RRDRKCSCSA LGDALTSADL DVVCRKALSR RSLRQKFQDA VGQCLPLRSH HHHHHHHLHS
     GSSRPFSVLF WSKRKIHVSE LMQDKCPFSP KSELARCWHL IKSNAAHPSG VKGLKASSSS
     SSTSPPQTPL SWDDICCSPG PGTSSLEDWD PSCGLRGADS GCDYILVPDL LQINNSPCYW
     GVLNRFEAEE LLEGQPEGTF LLRDSAQDEF LFSVSFRRYS RSLHARIEQN GKRFSFDVRD
     PCMYRDPSVT GLLRHYSDPA TCLFFEPLLS RPLPRTFPFS LQHLCRAIIC SCTTYRGIDN
     LPLPPQLREY LRQYHIKCDG ACAD
//