ID A0A673C7T5_9TELE Unreviewed; 2415 AA.
AC A0A673C7T5;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 28.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=atr {ECO:0000313|Ensembl:ENSSORP00005051616.1};
OS Sphaeramia orbicularis (orbiculate cardinalfish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Gobiaria; Kurtiformes; Apogonoidei; Apogonidae; Apogoninae; Sphaeramia.
OX NCBI_TaxID=375764 {ECO:0000313|Ensembl:ENSSORP00005051616.1, ECO:0000313|Proteomes:UP000472271};
RN [1] {ECO:0000313|Ensembl:ENSSORP00005051616.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Wellcome Sanger Institute Data Sharing;
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSORP00005051616.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSSORP00005051616.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR Ensembl; ENSSORT00005052849.1; ENSSORP00005051616.1; ENSSORG00005023016.1.
DR Proteomes; UP000472271; Chromosome 22.
DR GO; GO:0005694; C:chromosome; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000077; P:DNA damage checkpoint signaling; IEA:TreeGrafter.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:TreeGrafter.
DR CDD; cd00892; PIKKc_ATR; 1.
DR FunFam; 1.10.1070.11:FF:000009; Putative serine/threonine-protein kinase ATR; 1.
DR FunFam; 3.30.1010.10:FF:000011; serine/threonine-protein kinase ATR; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 3.30.1010.10; Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR056802; ATR-like_M-HEAT.
DR InterPro; IPR056803; ATR-like_N-HEAT.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR057564; HEAT_ATR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF69; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF23593; HEAT_ATR; 1.
DR Pfam; PF25030; M-HEAT_ATR; 1.
DR Pfam; PF25032; N-HEAT_ATR; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000472271};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1416..1959
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2067..2375
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2383..2415
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2415 AA; 271680 MW; 03D9001F1422CB95 CRC64;
VKMEGLEMSA MIPALQELTS ASAAEYDQAV QKPRQILCQF IDRILTDVDV VALGLSKKSS
SEPACVMLLD FVQHIIKSSS LMFANPACQP AEYPDTTQSC TDFSKWVAVR LLRVAASPDC
DVIHGRVSAV LCSLLHTLRV RAPFIFSCVA EDLITLAKDL SNILYNHIAT LTGQGHVLGL
QTQSQWPVTL TCISISPGCA SFYLTPSPLQ LSCPAALESL TAVTVGVITD ALRGVVSHHH
LSVAWEAACS ILANGNPKLR KISMVMLRQL VELGGFPEMK SHEFFMAYLD LLETHSSDLD
EPQPYEGELL NLTRCVFQSS GISHTHFEPM YLSQMFECVC TLGGADMKLG TEVKESLCFL
FRFLLSVAPV YESAASLRRQ RVTEVCRTLA CTVGTVNQAE CFNQIIILSV FLCFLFFPAP
QIRVDCVSLL AFVPHGVCET WRVCVFSKAL QSQDEAVRAA AVRAFPVLLH HLGNAYHNLI
NTTLLLRLED SSEQVMKELA RIVGQLSCVQ SEVSQLSDTQ SETPCPPVLV CHRLCLTSKH
AQNTAAFLKA SVVRPFLLLL RPQAPSSVKQ AFLEALPHLC QHVNVADGDS DSRAVLCALI
SLIEDSDPAV RIRFSQSVCF LLMENVRNSE QGSLNELLVA RLKEAFNNAK VNRDDDLRNT
LILTTGEIGR ASQGSLVSFS LLRLLHCLLS KSSPVSVAAY AQIRALAAAK GLKLQTLFSQ
YKNPICQFLV ESLHSRHASA LRSTPDQGGE SANQRELALD ILAQIAHAFD FPDLHRFLTR
TLQVLLPYLA AKASSTGSSL IRTLANELKA NRREILISNF KYIFSHLVCS CTKEELERAF
HYLQSETEIE LGSLLRQDFQ GLHNELLLRL GEHYQQVFNG LAILASFASN DDPYQGPRDI
TTPERMADYL QPKLLGILAF FNMQLLSSSA GEKDRKKLAL TSVMALMRLM GSKHISSVRV
KMMTTLRTGL RYREDFPLLC CQTWECFVRS VESAHLGPLL SHVIVALLPL IPLQPKETAA
IIRFLILENR EEVNDYLHEI YFLPDHPELK DIHTVLQNYK KLTASSSDLA AALQLSMRAV
QHENVDVRIH ALTSLRDMMH SNQEWLLRQV CASEAVEPVI SSLVAVLLKG CQDSSPEARL
LCGECLGELG AVDPGRLDLS HTHTNGDRNT FVSGVDDPNF AYDLLTELIR TFLAYADDVR
AQDSAAYAIQ ELLSIFECRE GRSDSPGRRL WRRFPEQMQE ILEPHLSSRY KSSQKEVNWS
KLKKPVYLSS RGSKFSDWSA TWAGYLISKV RHELASKVFT CCSFIIKHDY KVTIYLLPHI
LLYMLLGCTP AEQQEVTEEM LAVLTEGDGR GVGRGQETAS SLSQLSTQTV FSMLSHLTQW
SRHVLYSKPK HNGKWTFQSG EYQRVVAFLK GIPQDVLAKA SLRSKAYTRA VMHFEAYILE
NKENIQDHLT FLQTLYAAMH EPDGVRGVNA LRREEPSLRE QILEHESIGL LRDATACYDR
AIQLESDQIG HYHGVMTSML GLGQLSTVIT QVNGVLANKP QWKSELNTYR VEAAWKLGQW
DLLEDYLSSD CLSSNWGIRL SQLLLAAKKQ DTDTFYEKLK VVRKEQVVPL SAASYECGTY
QRGYEYIIRL HMLSELEHTF TELQKQKQGL APSLSQQPLH WSERLEMTQN SFRAKEPILA
LRRALLSLGS QPVFQELVGE CWLQSARVAR KAGHHQTAFN ALLNAENTHL AELVTEKAKW
LWSKGDVHQS LIVLQKGVAQ CFPDDQPITD PRRLQTKGKA MLLVGRFMEE TANFESNAIM
KAYKDVTNLL PEWEDGNFYL AKYYDKVMPM VTDNKLEKQG NLIHSLQHIA LQFGNQYIYQ
AMPRMLSLWL DFGAKVCECE KAGRADRQMR QELAKINMAV SEHCSNLAPY QFLTAFSQLI
SRVCHSSDEV FSVLMTIVAK VFLAYPQQAM WLMTAVSKSS YPMRMNRCNQ ILKKAISLKQ
SLEKFIGDAN RLTDKLLELC NKPVDGNSTT LSMSVHFKQL KRLVEEPTFS QILIPLQSVL
IPTLPSTGGA NTQHDAFPGH WAYLDGFEDS VEILASLQKP KKISLKASDG RSYTMMCKPK
DDLRKDCRLM EFNCLINKCL RKDAESRRRE LHIRTYAVIP LNEECGIIEW VNNTGGLRHI
LTKLYKERGI YLSGKELRKL ILPKTAPFEE KLRIHKEVLC ARHPPVFYEW FLRTFPDPTS
WYSSRSAYCR STAVMSMVGY ILGLGDRHGE NILFDSFTGE CVHVDFNCLF NKGETFDVPE
VVPFRLTQNM VHAMGPMGTE GLFRQACEVT LRLMRDQREP LTSVLKTFLH DPLVEWSKQA
KGLSKAQANE TGEIVNEKAK THVCDIEQRL QGVIKSRNKV LGLPLSIEGH VHYLIQEATD
DKLLCQMYLG WGPYL
//
