ID   A0A673H7S9_9TELE        Unreviewed;       623 AA.
AC   A0A673H7S9;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   08-OCT-2025, entry version 22.
DE   SubName: Full=Gamma-adducin-like {ECO:0000313|Ensembl:ENSSRHP00000021863.1};
GN   Name=LOC107717656 {ECO:0000313|Ensembl:ENSSRHP00000021863.1};
OS   Sinocyclocheilus rhinocerous.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Sinocyclocheilus.
OX   NCBI_TaxID=307959 {ECO:0000313|Ensembl:ENSSRHP00000021863.1, ECO:0000313|Proteomes:UP000472270};
RN   [1] {ECO:0000313|Ensembl:ENSSRHP00000021863.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm,
CC       cytoskeleton {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
CC       {ECO:0000256|ARBA:ARBA00006274}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A673H7S9; -.
DR   Ensembl; ENSSRHT00000022542.1; ENSSRHP00000021863.1; ENSSRHG00000011619.1.
DR   Proteomes; UP000472270; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0014069; C:postsynaptic density; IEA:TreeGrafter.
DR   GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051016; P:barbed-end actin filament capping; IEA:TreeGrafter.
DR   FunFam; 3.40.225.10:FF:000004; gamma-adducin isoform X1; 1.
DR   Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR   InterPro; IPR051017; Aldolase-II_Adducin_sf.
DR   InterPro; IPR001303; Aldolase_II/adducin_N.
DR   InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR   PANTHER; PTHR10672; ADDUCIN; 1.
DR   PANTHER; PTHR10672:SF5; GAMMA-ADDUCIN; 1.
DR   Pfam; PF00596; Aldolase_II; 1.
DR   SMART; SM01007; Aldolase_II; 1.
DR   SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472270}.
FT   DOMAIN          84..266
FT                   /note="Class II aldolase/adducin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01007"
FT   REGION          392..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          472..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..623
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        599..623
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   623 AA;  69608 MW;  27A79E09F063E1D1 CRC64;
     MLRLKCGPCE AFRDELEGLI QEQMNKGNDP TGLLALQQIA DFFMASSVAG FSTSPLSLGM
     VTPINDMFSM ESSTMVKGEK QIRCKLASLY RLVDLFSWAH FTSCYVTVRV SKEQDHILII
     PRGLSFAEAS ASNLVKVNIL GDVIDQGSTN LQIDPAGFSP HAAIYSVRPD VRCVIHISTP
     ATAAVSSMKC GLLPISQEAL ILGDIAYYNY QGSLDEQEER IELQKALGPS AKVLVLRNHG
     VVALGETIEE AFHYIYNAQF ACEIQVNAFS CAGGVENLIV LDLEKYRSRT QGVAEAGVNM
     GSQHKWRLGE LEFESLMRML DNLGYRTGYT YRHPIVREKP RHKSEVEIPA TVTAFMFDDD
     DAPRFPLKLL QQRQQREKTR WLNSPNCYMK VNVSDGASEE NGRTKTMWMK SDDGGNTSGT
     PIRIEDPNQF VPLNTNPSDV LERRNKIREQ NRFDMMTAGP QSQRLAGIVV ERPPPYMGDD
     EEQTGPLPPN PFSELSEKVL QDYQKRAERQ QLGVDDEEQL TSDDASTLSQ SVSPQNTPAK
     EENHSGVMLN GKDQHCDEDE LIKRVSQLTT SVESVEISVR SGEKIEEALT PESSPSKSPN
     KKKKKFRTPS FLKKNKKKEK VEA
//