ID A0A673HXL6_9TELE Unreviewed; 1219 AA.
AC A0A673HXL6;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 10-JUN-2026, entry version 26.
DE SubName: Full=Helicase SKI2W-like {ECO:0000313|Ensembl:ENSSRHP00000032690.1};
GN Name=skic2 {ECO:0000313|Ensembl:ENSSRHP00000032690.1};
OS Sinocyclocheilus rhinocerous.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Sinocyclocheilus.
OX NCBI_TaxID=307959 {ECO:0000313|Ensembl:ENSSRHP00000032690.1, ECO:0000313|Proteomes:UP000472270};
RN [1] {ECO:0000313|Proteomes:UP000472270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26728391;
RA Yang J., Chen X., Bai J., Fang D., Qiu Y., Jiang W., Yuan H., Bian C.,
RA Lu J., He S., Pan X., Zhang Y., Wang X., You X., Wang Y., Sun Y., Mao D.,
RA Liu Y., Fan G., Zhang H., Chen X., Zhang X., Zheng L., Wang J., Cheng L.,
RA Chen J., Ruan Z., Li J., Yu H., Peng C., Ma X., Xu J., He Y., Xu Z., Xu P.,
RA Wang J., Yang H., Wang J., Whitten T., Xu X., Shi Q.;
RT "The Sinocyclocheilus cavefish genome provides insights into cave
RT adaptation.";
RL BMC Biol. 14:1-1(2016).
RN [2] {ECO:0000313|Ensembl:ENSSRHP00000032690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00047984};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A673HXL6; -.
DR Ensembl; ENSSRHT00000033642.1; ENSSRHP00000032690.1; ENSSRHG00000015910.1.
DR Proteomes; UP000472270; Unassembled WGS sequence.
DR GO; GO:0055087; C:Ski complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IEA:TreeGrafter.
DR CDD; cd18027; DEXHc_SKIV2L; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR FunFam; 3.40.50.300:FF:000354; ATP-dependent RNA helicase SKI2; 1.
DR FunFam; 3.40.50.300:FF:000447; helicase SKI2W isoform X2; 1.
DR FunFam; 1.10.3380.30:FF:000001; Ski2 ATP-dependent RNA helicase; 1.
DR FunFam; 1.10.3380.30:FF:000015; SKI2 homolog, superkiller viralicidic activity 2-like; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 1.20.1500.20; -; 1.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR025696; Beta-barrel_MTR4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C-like.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR050699; RNA-DNA_Helicase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF1; ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000472270};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 301..457
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 574..739
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 143..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1219 AA; 137184 MW; 379DF6B7FDAAA5F4 CRC64;
MNCCFLLCVD LPPVGPDDLP LSLLEMGCSG RFELITHPLP KNRPLPPHST LPHGLPPTCL
DLKTEVEKRF LRDPAWLPVH DVDDSFHKFL QYEMRHKEVD SLLHCSLSPL HSGLSVVRDP
TTGMLLDFTE VLLEDTGLSA KNSLSLQRQP GPPSESLRGS NTNYPFLPAG MEELTLEQIK
KKSEREEDID FEKGWWSVLF LWITFRKRSH LFICPTFVFV WSFFLTTCTP QDSGNSPSQP
SANTVHLSEQ KKNPQQEDKG DLKKWAVPVD ISSPCDDFYK RIPDPAFKYP FELDVFQKQA
ILRLEAHDSV FVAAHTSAGK TVVAEYAIAL SQKHMTRTIY TSPIKALSNQ KFRDFKTTFG
DVGLLTGDVQ LSPESSCLIM TTEILRSMLY NGSEVIRDLE WVIFDEVHYI NDAERGVVWE
EVLIMLPEHV SIILLSATVP NAVEFSEWIG RIKKWSIYVI STIKRPVPLE HYLYTGNSTK
TQKELFLLLD STGNFLTKGC FQIETNAKKE RTSKHAQSFG TKNVSQHNTT ASQDRAVWQT
LLNYLSQRQQ TPVVAFTFSR TRCDENARSL TSLDLTSSIE KSEIHSFLQK SLTRLRGGDR
QLPQILLMRD LLKRGIGVHH SGILPILKEI IEMLFSRGLV KVLFATETFA MGVNMPARTV
VFDSIRKHDG TGFRNLLPGE YIQMAGRAGR RGLDATGTVI ILCKAGVHDM GNLHAMMLGK
PTVLQSQFRL TYTMILNLLR VEALRVTDMM RRSFSENHRD TQAHEKRISE LRNTLSSLPP
LDTEGQLSDI LSYYHTITEL LITTETLQRA VLESVNGLKA LSVGRVVIVN NSQHHNALGV
ILQVSNDAVN RTFTALIICE KGNEEAAGDD QSNKAFHPIY STSLFIPEGP CSHTVQKLKL
QDISAITTKT LKVIPERIID NYNKRQQPRF RLDPPGQAIS TATQELLRLA EASPNGITTL
DPVNDLHLKG VDVVEGVMRH RVLQGCLKDF HCIHSPTFTE QERMSVQEEL DKLLFLVSDQ
SLTLLPEYHQ RIKVLEALQY VDSTGAVQLK GRVACQISSH ELLLTELLFE NTLSPLAPEE
SAALLSCLVF TQNTQIDPHI TNTLQEGISQ VLNVAQRIGE LQRDCGIAQT AEDFVAQFKF
GLTEVVYCWA RGMPFSEIAQ LTNVQEGTIV RCIQRLDEIL KEVRQAARIV GDSVLGSKME
RASLAIRRDI VFTASLYTH
//
