ID A0A673MI86_9TELE Unreviewed; 780 AA.
AC A0A673MI86;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Protein argonaute-3-like {ECO:0000313|Ensembl:ENSSRHP00000087886.1};
GN Name=LOC107748720 {ECO:0000313|Ensembl:ENSSRHP00000087886.1};
OS Sinocyclocheilus rhinocerous.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Cyprininae; Sinocyclocheilus.
OX NCBI_TaxID=307959 {ECO:0000313|Ensembl:ENSSRHP00000087886.1, ECO:0000313|Proteomes:UP000472270};
RN [1] {ECO:0000313|Ensembl:ENSSRHP00000087886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSRHP00000087886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000256|ARBA:ARBA00008201}.
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DR AlphaFoldDB; A0A673MI86; -.
DR Ensembl; ENSSRHT00000090259.1; ENSSRHP00000087886.1; ENSSRHG00000041806.1.
DR Proteomes; UP000472270; Unassembled WGS sequence.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-ARBA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR CDD; cd02846; PAZ_argonaute_like; 1.
DR FunFam; 2.170.260.10:FF:000001; Protein argonaute-2; 1.
DR FunFam; 3.40.50.2300:FF:000005; Protein argonaute-2; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.170.260.10; paz domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032472; ArgoL2.
DR InterPro; IPR032473; Argonaute_Mid_dom.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16488; ArgoL2; 1.
DR Pfam; PF16487; ArgoMid; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; PAZ domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472270};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 676..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..361
FT /note="PAZ"
FT /evidence="ECO:0000259|PROSITE:PS50821"
FT DOMAIN 530..633
FT /note="Piwi"
FT /evidence="ECO:0000259|PROSITE:PS50822"
SQ SEQUENCE 780 AA; 88213 MW; 2D422DA6569BE286 CRC64;
SNMFDMIGAV QDSIGERLAL PDNPPVGAAP LFSVPRRPGY GTMGKPIKLL ANCFQVDIPK
MDVYLYDVDI TPEKCPRRVN REVVNSMVQH FKVTIFGDRR PVYDGKKSLY TAQPLPVDLD
VTLPGEGGKD RLFKVTIKFV SLVSWHLLHE VLTGRSTPDP LNLDKPISTN PVHAVDVVMR
HLPSMKYTPV GRSFFSSPEG YDHPLGGGRE VWFGFHQSVR PAMWKMMLNI DVSATAFYKA
QPVIPFMCEV LDIHNIDEQP RPLTDSHRVK FTKEIRGLKV EVTHCGTMRR KYRVCNVTRR
PASHQTFPLQ LENGQTVERT VAQYFREKYN LQLKYPHLPC LQVGQEQKHT YLPLEVCNIV
AGQRCIKKLT DNQTSTMIKA TARSAPDRQE EISRLVRSAN YNSDPFVQEF QFRVRDEMAE
VTGRVLPAPM LQYGGRNRTV ATPSHGVWDM RGKQFHTGVE IKMWAIACFA TQRQCREEVL
KGFTDQLRKI SKDAGMPIQG QPCFCKYAQG ADNVEPMFRH LKNTYAGLQL IIVILPGKTP
VYAEVKRVGD TLLGMATQCV QVKNVVKTSP QTLSNLCLKI NVKLGGINNI LVPHQRPSVF
QQPVIFLGAD VTHPPAGDGK KPSIAAVVGS MDAHPSRYCA TVRVQRAVPH ICTLYPLRFH
PCACLLCPPS VLKRRFFFFF FLLYIYVCFK LTLFNQFLYI DVCTLLLCTV YCTYCVSLYL
PGMSRKMYFI VYISASAHFF LLFHSAEGSH VSGQSNGRDP QVLAKAVQIH HDTLRTMYFA
//
