ID   A0A673N5J2_9TELE        Unreviewed;       521 AA.
AC   A0A673N5J2;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   18-JUN-2025, entry version 20.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   Name=LOC107723221 {ECO:0000313|Ensembl:ENSSRHP00000098155.1};
OS   Sinocyclocheilus rhinocerous.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Sinocyclocheilus.
OX   NCBI_TaxID=307959 {ECO:0000313|Ensembl:ENSSRHP00000098155.1, ECO:0000313|Proteomes:UP000472270};
RN   [1] {ECO:0000313|Ensembl:ENSSRHP00000098155.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR   AlphaFoldDB; A0A673N5J2; -.
DR   Ensembl; ENSSRHT00000100827.1; ENSSRHP00000098155.1; ENSSRHG00000048211.1.
DR   Proteomes; UP000472270; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20338; BRcat_RBR_RNF19; 1.
DR   CDD; cd20355; Rcat_RBR_RNF19; 1.
DR   FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR   FunFam; 3.30.40.10:FF:000052; RBR-type E3 ubiquitin transferase; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472270};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   TRANSMEM        249..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        302..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          17..239
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          21..68
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          472..521
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..495
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   521 AA;  57097 MW;  99ADFEA4457FBFC2 CRC64;
     MGVLSLSSSS QEQLLEHLVE CPLCLLSQPH GHFPRLSSCQ HRACTDCLRQ YLRIEILESR
     VGIACPQCPE ALALLDVRAI LDDGALLERF EEFQLRRFLA ADPDTRWCPA PDCSYAVIAY
     GCAECPKLSC GREGCETEFC YHCRQLWHPD QTCDQARRQR ARHTSGANDV STLYVFNEEP
     GDAEEIKPCP RCGAYIMKTN DGSCNRMNCT VCACQFCWLC MQEITDVHYL SPSGCTFWGK
     KPWSQTRKVL WQVGMLLGAP VVISLIAGIA IPVIIVGIPI YMGRKVHGRC KKNNISGSKH
     YLTVASGVMM SVFVSPVIAA ITVGVGVPLM LTYVYGVVPM SLCRNGWCRP QTETPEVRNI
     QLEDLANYLL FSHVVSDHWT GQTNPALSNG SVQEVSVNVE EVMPLPSTSV VQSGAKGSVE
     PSNDGHVDST EQVVQSDDVD AVEECAFSST QTFALSREGT NIEVRVEIEA QPRDGRKPSL
     SSILSSKSLS AESLSQPCEP LCASQQTGST DPVPVPEIDS V
//