ID   A0A673TBW0_SURSU        Unreviewed;        65 AA.
AC   A0A673TBW0;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   18-JUN-2025, entry version 21.
DE   RecName: Full=Polyadenylate-binding protein-interacting protein 2 {ECO:0000256|ARBA:ARBA00040702};
OS   Suricata suricatta (Meerkat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX   NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005006451.1, ECO:0000313|Proteomes:UP000472268};
RN   [1] {ECO:0000313|Ensembl:ENSSSUP00005006451.1, ECO:0000313|Proteomes:UP000472268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA   Clutton-Brock T.H.;
RT   "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL   Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSUP00005006451.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- FUNCTION: Acts as a repressor in the regulation of translation
CC       initiation of poly(A)-containing mRNAs. Its inhibitory activity on
CC       translation is mediated via its action on PABPC1. Displaces the
CC       interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for
CC       binding to PABPC1. Its association with PABPC1 results in disruption of
CC       the cytoplasmic poly(A) RNP structure organization.
CC       {ECO:0000256|ARBA:ARBA00037448}.
CC   -!- SUBUNIT: Interacts with the second and third RRM domains and C-terminus
CC       regions of PABPC1 in a 2:1 stoichiometry.
CC       {ECO:0000256|ARBA:ARBA00038779}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the PAIP2 family.
CC       {ECO:0000256|ARBA:ARBA00006858}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A673TBW0; -.
DR   Ensembl; ENSSSUT00005007452.1; ENSSSUP00005006451.1; ENSSSUG00005004186.1.
DR   OMA; HMWMENE; -.
DR   Proteomes; UP000472268; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:InterPro.
DR   InterPro; IPR040396; PAIP2-like.
DR   InterPro; IPR009818; PAM2_motif.
DR   PANTHER; PTHR13154; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR13154:SF2; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR   Pfam; PF07145; PAM2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472268};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..13
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   65 AA;  7495 MW;  F7F6D11C2285B1C1 CRC64;
     MKDPSHSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIGED NLNPNAKEFV
     PGVKY
//