ID A0A673TI74_SURSU Unreviewed; 783 AA.
AC A0A673TI74;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE RecName: Full=DNA-binding protein RFX2 {ECO:0000256|ARBA:ARBA00039910};
DE AltName: Full=Regulatory factor X 2 {ECO:0000256|ARBA:ARBA00042136};
OS Suricata suricatta (Meerkat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005009210.1, ECO:0000313|Proteomes:UP000472268};
RN [1] {ECO:0000313|Ensembl:ENSSSUP00005009210.1, ECO:0000313|Proteomes:UP000472268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA Clutton-Brock T.H.;
RT "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSUP00005009210.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- FUNCTION: Transcription factor that acts as a key regulator of
CC spermatogenesis. Acts by regulating expression of genes required for
CC the haploid phase during spermiogenesis, such as genes required for
CC cilium assembly and function. Recognizes and binds the X-box, a
CC regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on
CC promoters. Probably activates transcription of the testis-specific
CC histone gene H1-6. {ECO:0000256|ARBA:ARBA00046188}.
CC -!- SUBUNIT: Homodimer; probably only forms homodimers in testis.
CC Heterodimer; heterodimerizes with RFX1 and RFX3.
CC {ECO:0000256|ARBA:ARBA00046788}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A673TI74; -.
DR Ensembl; ENSSSUT00005010582.1; ENSSSUP00005009210.1; ENSSSUG00005005915.1.
DR Proteomes; UP000472268; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:TreeGrafter.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:TreeGrafter.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR FunFam; 1.10.10.10:FF:000017; transcription factor RFX3 isoform X1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003150; DNA-bd_RFX.
DR InterPro; IPR039779; RFX-like.
DR InterPro; IPR007668; RFX1_trans_act.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12619:SF17; DNA-BINDING PROTEIN RFX2; 1.
DR PANTHER; PTHR12619; RFX TRANSCRIPTION FACTOR FAMILY; 1.
DR Pfam; PF25340; BCD_RFX; 1.
DR Pfam; PF04589; RFX1_trans_act; 1.
DR Pfam; PF02257; RFX_DNA_binding; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51526; RFX_DBD; 1.
PE 4: Predicted;
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022871};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000472268};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 154..229
FT /note="RFX-type winged-helix"
FT /evidence="ECO:0000259|PROSITE:PS51526"
FT REGION 246..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 783 AA; 85112 MW; D1B600B0858CA4AA CRC64;
MQPISLPRVQ QVPQQVQPVQ HAYPPQVQYV EGGDTVYTNG ALRTAYAYNP EPQMYVPSST
ASYFEAAGGA QVTVAGSSPP AVPSHGMVGI AMDVGGTPIV SGAGAYLIHG GMDSSRHPLA
HASRSSPATL EMAIENLQKS EGITSHKSGL LHSHLQWLLD NYETAEGVSL PRSSLYNHYL
RHCQEHKLDP VNAASFGKLI RSVFMGLRTR RLGTRGNSKY HYYGIRLKPD SPLNRLQEDP
QYMAMRQQPT HQKPRYRPAQ KTDSLGDGGS HGGPHSTPEQ AMAAQSQHHQ QYIDVSHVFP
EFPAPDLGGA LLRESVTLHD VKALQLAYRR HCEATLDVVV NLQFHYIEKL WLSFWNSKAP
SGDGPASLPA SDGEAAGAVL PKDKLVSLCK CEPILKWMRS CDHILYQALV EVLIPDVLRP
VPSTLTQAIR NFAKSLEGWL TNAMSDFPQQ VIQTKVGVVS AFAQTLRRYT SLNHLAQAAR
AVLQNTSQIN QMLSDLNRVD FANVQEQASW VCQCEEGVVQ RLEQDFKLTL QQQSSLDQWA
AWLDGVVTQV LRQHAGSPSF PKAARQFLLK WSFYSSMVIR DLTLRSAASF GSFHLIRLLY
DEYMFYLVEH RVAEATGETP IAVMGEFNDL ASLSLTLLDK GGCVHGPVPE ALRLFPPPLR
SPWGGLGACR SCSRQAGGLG SSSDTHAGLA TPPDSEEQSL PQVCASRLGL VPSPGTSTWG
SGAGPQPRPP TATSPHLAPR DGDTSGPGGP CQECDPPGGR WSQEASLGTA GWGPWPGHAC
APP
//
