ID A0A673UU85_SURSU Unreviewed; 490 AA.
AC A0A673UU85;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE SubName: Full=FMR1 autosomal homolog 1 {ECO:0000313|Ensembl:ENSSSUP00005028119.1};
OS Suricata suricatta (Meerkat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005028119.1, ECO:0000313|Proteomes:UP000472268};
RN [1] {ECO:0000313|Ensembl:ENSSSUP00005028119.1, ECO:0000313|Proteomes:UP000472268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA Clutton-Brock T.H.;
RT "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSUP00005028119.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule
CC {ECO:0000256|ARBA:ARBA00004331}.
CC -!- SIMILARITY: Belongs to the FMR1 family.
CC {ECO:0000256|ARBA:ARBA00006633}.
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DR AlphaFoldDB; A0A673UU85; -.
DR Ensembl; ENSSSUT00005032117.1; ENSSSUP00005028119.1; ENSSSUG00005017412.1.
DR Proteomes; UP000472268; Chromosome 5.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:TreeGrafter.
DR GO; GO:0043005; C:neuron projection; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:TreeGrafter.
DR GO; GO:0045182; F:translation regulator activity; IEA:TreeGrafter.
DR GO; GO:0051028; P:mRNA transport; IEA:TreeGrafter.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IEA:TreeGrafter.
DR GO; GO:0045727; P:positive regulation of translation; IEA:TreeGrafter.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:TreeGrafter.
DR GO; GO:0099577; P:regulation of translation at presynapse, modulating synaptic transmission; IEA:TreeGrafter.
DR CDD; cd22504; KH_I_FXR1_rpt1; 1.
DR CDD; cd22507; KH_I_FXR1_rpt2; 1.
DR CDD; cd22510; KH_I_FXR1_rpt3; 1.
DR CDD; cd20475; Tudor_Agenet_FXR1_rpt2; 1.
DR FunFam; 2.30.30.140:FF:000001; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000004; Fragile X mental retardation 1, isoform CRA_e; 1.
DR FunFam; 3.30.1370.10:FF:000017; Fragile X mental retardation syndrome-related protein 1; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR008395; Agenet-like_dom.
DR InterPro; IPR040148; FMR1.
DR InterPro; IPR022034; FMR1-like_C_core.
DR InterPro; IPR040472; FMRP_KH0.
DR InterPro; IPR032172; FXR1_C1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR047494; KH_I_FXR1_rpt1.
DR InterPro; IPR047495; KH_I_FXR1_rpt2.
DR InterPro; IPR047496; KH_I_FXR1_rpt3.
DR InterPro; IPR047427; Tudor_Agenet_FXR1_rpt2.
DR InterPro; IPR041560; Tudor_FRM1.
DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1.
DR PANTHER; PTHR10603:SF6; RNA-BINDING PROTEIN FXR1; 1.
DR Pfam; PF05641; Agenet; 1.
DR Pfam; PF12235; FXMRP1_C_core; 2.
DR Pfam; PF16096; FXR_C1; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF17904; KH_9; 1.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS51641; AGENET_LIKE; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Myogenesis {ECO:0000256|ARBA:ARBA00022541};
KW Reference proteome {ECO:0000313|Proteomes:UP000472268};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117}.
FT DOMAIN 4..66
FT /note="Agenet-like"
FT /evidence="ECO:0000259|PROSITE:PS51641"
FT REGION 332..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..411
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..444
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..460
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 55120 MW; 2368DA492D20C481 CRC64;
MAELTVEVRG SNGAFYKVYS RANDQEPCGW WLAKVRMMKG EFYVIEYAAC DATYNEIVTF
ERLRPVNQNK TVKKNTFFKC TVDVPEDLRE ACANENAHKD FKKAVGACRI FYHPETTQLM
ILSASEATVK RVNILSDMHL RSIRTKLMLM SRNEEATKHL ECTKQLAAAF HEEFVVREDL
MGLAIGTHGS NIQQARKVPG VTAIELDEDT GTFRIYGESA DAVKKARGFL EFVEDFIQVP
RNLVGKVIGK NGKVIQEIVD KSGVVRVRIE GDNENKLPRE DGMVPFVFVG TKESIGNVQV
LLEYHIAYLK EVEQLRMERL QIDEQLRQIG SRSYSGRGRG RRGPNYTSGY GTNSELSNPS
ETESERKDEL SDWSLAGEDD RESRHQRDSR RRPGGRGRSV SGGRGRGGPR GGKSSISSVL
KDPDSNPYSL LDNTESDQTA DTDASESHHS TNRRRRSRRR RTDEDAVLMD GMTESDTASV
NENGLGKRCD
//
