ID A0A673V1D8_SURSU Unreviewed; 979 AA.
AC A0A673V1D8;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 18-JUN-2025, entry version 21.
DE SubName: Full=Huntingtin interacting protein 1 related {ECO:0000313|Ensembl:ENSSSUP00005031513.1};
OS Suricata suricatta (Meerkat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005031513.1, ECO:0000313|Proteomes:UP000472268};
RN [1] {ECO:0000313|Ensembl:ENSSSUP00005031513.1, ECO:0000313|Proteomes:UP000472268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA Clutton-Brock T.H.;
RT "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSUP00005031513.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}.
CC -!- SIMILARITY: Belongs to the SLA2 family.
CC {ECO:0000256|ARBA:ARBA00010135}.
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DR AlphaFoldDB; A0A673V1D8; -.
DR Ensembl; ENSSSUT00005035950.1; ENSSSUP00005031513.1; ENSSSUG00005020270.1.
DR Proteomes; UP000472268; Chromosome 14.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:TreeGrafter.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IEA:TreeGrafter.
DR GO; GO:0051015; F:actin filament binding; IEA:TreeGrafter.
DR GO; GO:0035615; F:clathrin adaptor activity; IEA:TreeGrafter.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:TreeGrafter.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:TreeGrafter.
DR GO; GO:0007015; P:actin filament organization; IEA:TreeGrafter.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:TreeGrafter.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR FunFam; 1.20.1410.10:FF:000002; Huntingtin interacting protein 1; 1.
DR FunFam; 1.20.5.1700:FF:000002; Huntingtin interacting protein 1; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 6.10.250.920; -; 1.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR032422; HIP1_clath-bd.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR030224; Sla2_fam.
DR PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR10407:SF10; HUNTINGTIN-INTERACTING PROTEIN 1-RELATED PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR Pfam; PF16515; HIP1_clath_bdg; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000472268}.
FT DOMAIN 682..923
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 331..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 882..918
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 438..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 109381 MW; D216AC9FBC94624F CRC64;
MSLGVKKTLP VVAVVDAAQL SGPQRPRCSE GHLHDRYGQL VNVYTKLLLT KISFHLKHPQ
FPAGLEVTDE VLEKTAGTDV NNIFQLTVEM FDYMDCELRL SESVFRQLNT AIAVSQMSSG
QCRLAPLIQV IQDCSHLYHY TVKLMFKLHA CLPADTLQGH RDRFHEQFHS LRNFFRRASD
MLYFKRLIQI PRLPEGPPNF LRASALAEHI KPVVVIPEEA PEDEEPENLI EISTGPPAAE
PAVVADLFEQ TFGPPNGSLK DDRDVQIETL KREVEALRAE LEKIKLEAQR YVSQLKGQVN
ALEAELEEQR KQKQKALVDN EQLRHELAQL RAAQRDAQRS QGLREEAEKR ASATEARYQK
LKEKHSELIS THAELLRKNA DTAKQLTVTQ QSQEEVARVK EQLAFQMEQV RRESELKLEE
QTDLLEKLKR ELDAKEGELV RTQEALSRTE ESGSELNSRL DALSAEKAEL SSAMQRREAD
LRAAQGLVRE KEEALSREQQ RGSQEAAELQ RQLADKESQE QELQRRLVDE QFAVLQATAT
EAERILQDAV AKLDDPLHLR CTSSPDYLVS RAQAALDAVS ALEKGHAQYL VSESDASVLV
AALTQFSYLA ADTIVRGSAT SHLAPTDPAD RLVDTCRECG ARALELVGQL RQRQTLRQAR
PGLVRTPLRG ILQLGQELKP KSLDVRQEEL GAMVDKEMAA TSAAIEDAVR RIEDMMNQAR
HASSGVKLEV NERILNSCTD LMKAIRLLVT TSTSLQKEIV EGGRGAATQQ EFYAKNSRWT
EGLISASKAV GWGATQLVES ADRVVLHTGK YEELIVCSHE IAASTAQLVA ASKVKADKHS
PHLGRLQECS RTVNEMAANV VASTTSGQEQ IEERDTMDFS GLSLIKLKKQ EMETQVRVLE
LEKTLEVERV RLGELRKQHY VLAGGVGTPS EEEPSRPSAA PRSGTSKKPP LAQKPSVAPR
QDQQLDRKDG IYPAQLVNY
//
