ID A0A673VLH3_SURSU Unreviewed; 555 AA.
AC A0A673VLH3;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE SubName: Full=Phosphatidylinositol glycan anchor biosynthesis class S {ECO:0000313|Ensembl:ENSSSUP00005034270.1};
GN Name=PIGS {ECO:0000313|Ensembl:ENSSSUP00005034270.1};
OS Suricata suricatta (Meerkat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Herpestidae; Suricata.
OX NCBI_TaxID=37032 {ECO:0000313|Ensembl:ENSSSUP00005034270.1, ECO:0000313|Proteomes:UP000472268};
RN [1] {ECO:0000313|Ensembl:ENSSSUP00005034270.1, ECO:0000313|Proteomes:UP000472268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dudchenko O., Lieberman Aiden E., Tung J., Barreiro L.B.,
RA Clutton-Brock T.H.;
RT "A Chromosome-scale Meerkat (S. suricatta) Genome Assembly.";
RL Submitted (MAY-2019) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSUP00005034270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSSSUP00005034270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
CC -!- SIMILARITY: Belongs to the PIGS family.
CC {ECO:0000256|ARBA:ARBA00005316}.
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DR RefSeq; XP_029783782.1; XM_029927922.1.
DR AlphaFoldDB; A0A673VLH3; -.
DR Ensembl; ENSSSUT00005039062.1; ENSSSUP00005034270.1; ENSSSUG00005021987.1.
DR GeneID; 115282093; -.
DR CTD; 94005; -.
DR OMA; AEHKYAV; -.
DR OrthoDB; 28748at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000472268; Chromosome 17.
DR GO; GO:0042765; C:GPI-anchor transamidase complex; IEA:InterPro.
DR GO; GO:0016255; P:attachment of GPI anchor to protein; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR019540; PtdIno-glycan_biosynth_class_S.
DR PANTHER; PTHR21072; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR PANTHER; PTHR21072:SF13; GPI TRANSAMIDASE COMPONENT PIG-S; 1.
DR Pfam; PF10510; PIG-S; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000472268};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 555 AA; 61689 MW; D1AA79C360DACEBA CRC64;
MAAPGAAATD LEVVRGKRAA LFFAAVAIVL GLPLWWKTTE TYRAPLPYSE ISGLNALQLR
LMVPVTVVFT RESVPLDDQE KLPFTVVHER EIPLKYKMKI KCRFQKAYRR ALDHEEEALS
LGSMQEAEAM LAEPQEQSEG SLTVYVIPEH SSLLPQDMTS YIGPERMAVV RGIMHREAFS
IVGRRVIQVA QAMSLTEDVL AAALADHLPE DKWSSDKRRP LKSSLGYEIT FSLLNPDPKS
HDVHWDIEGA VRRYVQPFLS ALSAAGNFSV DSQILYYAVL GVNPRFDPAS SSYYLAMHSL
PHVINPVESR LGSSAASLYP VLNFLLYVPE LAHSPLYIQD KDGAPVATNA FHSPRWGGIM
VYNVDPKAYN ASKLPVRVEV DMVRVMEVFL AQLRLLFGIA QPQLPLKCLF SGPKPEGLTT
WELDRLLWAR SVENLATATT TLTSLAQLLG KISNIVIKDD VASEVYRAVA AVQKAAEELA
SGHLASAFAA SQEAVTSSER AFFDPSLLHL LYFPDDQKFA IYIPLFLPMA VPILLSLVKI
FLETRKSWKK PEKID
//
