ID   A0A674C690_SALTR        Unreviewed;       808 AA.
AC   A0A674C690;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   28-JAN-2026, entry version 25.
DE   RecName: Full=Protein argonaute-1 {ECO:0000256|ARBA:ARBA00070769};
GN   Name=ago3a {ECO:0000313|Ensembl:ENSSTUP00000079014.1};
OS   Salmo trutta (Brown trout).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000079014.1, ECO:0000313|Proteomes:UP000472277};
RN   [1] {ECO:0000313|Ensembl:ENSSTUP00000079014.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSSTUP00000079014.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC       {ECO:0000256|ARBA:ARBA00004201}.
CC   -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC       {ECO:0000256|ARBA:ARBA00008201}.
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DR   AlphaFoldDB; A0A674C690; -.
DR   Ensembl; ENSSTUT00000084135.1; ENSSTUP00000079014.1; ENSSTUG00000032836.1.
DR   GeneTree; ENSGT00940000155256; -.
DR   Proteomes; UP000472277; Chromosome 3.
DR   GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR   GO; GO:0016442; C:RISC complex; IEA:UniProtKB-ARBA.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR   CDD; cd02846; PAZ_argonaute_like; 1.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   FunFam; 2.170.260.10:FF:000001; Protein argonaute-2; 1.
DR   FunFam; 3.30.420.10:FF:000001; Protein argonaute-2; 1.
DR   FunFam; 3.40.50.2300:FF:000005; Protein argonaute-2; 1.
DR   Gene3D; 3.40.50.2300; -; 1.
DR   Gene3D; 2.170.260.10; paz domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR032473; Argonaute_Mid_dom.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16487; ArgoMid; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; PAZ domain; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT   DOMAIN          161..280
FT                   /note="PAZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50821"
FT   DOMAIN          466..767
FT                   /note="Piwi"
FT                   /evidence="ECO:0000259|PROSITE:PS50822"
SQ   SEQUENCE   808 AA;  91772 MW;  FC90E6D116BE29A6 CRC64;
     MVQHFKVTIF GDRRPVYDGK RSLYTANPLP VATAGVDLDV TLPGEGGKDR PFKVSIKFVS
     LVSWHMLHEV LTGRSVPEPL ELDKPISTNP VHAVDVVLRH LPSMKYTPVG RSFFSAPEGY
     DHPLGGGREV WFGFHQSVRP AMWKMMLNID VSATAFYKAQ PVIQFMCEVL DIHNIDEQPR
     PLTDSHRVKF TKEIKGLKVE VTHCGTMRRK YRVCNVTRRP ASHQTFPLQL ENGQTVERTV
     AQYFREKYSL QLKYPHLPCL QVGQEQKHTY LPLEVCNIVA GQRCIKKLTD NQTSTMIKAT
     ARSAPDRQEE ISRLVRSANY EADPFVQEFQ FKVRDEMAHV TGRVLPAPML QYGGRVSTEH
     FMQINRTTLW FQNRTVATPS HGVWDMRGKQ FHTGVEIKMW AIACFATQRQ CREEILKGFT
     DQLRKISKDA GMPIQGQPCF CKYAQGADSV EPMFRHLKNT YSGLQLIIVI LPGKTPVYAE
     VKRVGDTLLG MATQCVQVKN VVKTSPQTLS NLCLKINVKL GGINNILVPH QRPSVFQQPI
     IFLGADVTHP PAGDGKKPSI AAVVGSMDAH PSRYCATVRV QRPRQEVIQD LASMVRELLI
     QFYKSTRYKP TRIIFYRDGV SEGQFRQVLY YELLAIREAC IGLEKEYQPG ITYIVVQKRH
     HTRLFCADRN ERVGRSGNIP AGTTVDTDIT HPYEFDFYLC SHAGIQGTSR PSHYHVLWDD
     NCFTADEFQL LTYQLCHTYV RCTRSVSIPA PAYYAHLVAF RARYHLVDKE HDSAEGSHVS
     GQSNGRDPQA LAKAVQIHHD TLRTMYFA
//