ID A0A674D795_SALTR Unreviewed; 808 AA.
AC A0A674D795;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 25.
DE RecName: Full=Protein argonaute-1 {ECO:0000256|ARBA:ARBA00070769};
GN Name=AGO1 {ECO:0000313|Ensembl:ENSSTUP00000091795.1};
GN Synonyms=LOC115177111 {ECO:0000313|Ensembl:ENSSTUP00000091795.1};
OS Salmo trutta (Brown trout).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8032 {ECO:0000313|Ensembl:ENSSTUP00000091795.1, ECO:0000313|Proteomes:UP000472277};
RN [1] {ECO:0000313|Ensembl:ENSSTUP00000091795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSSTUP00000091795.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body
CC {ECO:0000256|ARBA:ARBA00004201}.
CC -!- SIMILARITY: Belongs to the argonaute family. Ago subfamily.
CC {ECO:0000256|ARBA:ARBA00008201}.
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DR AlphaFoldDB; A0A674D795; -.
DR Ensembl; ENSSTUT00000097672.1; ENSSTUP00000091795.1; ENSSTUG00000039351.1.
DR GeneTree; ENSGT00940000158568; -.
DR Proteomes; UP000472277; Chromosome 37.
DR GO; GO:0000932; C:P-body; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-ARBA.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR CDD; cd02846; PAZ_argonaute_like; 1.
DR CDD; cd04657; Piwi_ago-like; 1.
DR FunFam; 2.170.260.10:FF:000001; Protein argonaute-2; 1.
DR FunFam; 3.30.420.10:FF:000001; Protein argonaute-2; 1.
DR FunFam; 3.40.50.2300:FF:000005; Protein argonaute-2; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 2.170.260.10; paz domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR014811; ArgoL1.
DR InterPro; IPR032472; ArgoL2.
DR InterPro; IPR032473; Argonaute_Mid_dom.
DR InterPro; IPR032474; Argonaute_N.
DR InterPro; IPR003100; PAZ_dom.
DR InterPro; IPR036085; PAZ_dom_sf.
DR InterPro; IPR003165; Piwi.
DR InterPro; IPR045246; Piwi_ago-like.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR22891; EUKARYOTIC TRANSLATION INITIATION FACTOR 2C; 1.
DR Pfam; PF08699; ArgoL1; 1.
DR Pfam; PF16488; ArgoL2; 1.
DR Pfam; PF16487; ArgoMid; 1.
DR Pfam; PF16486; ArgoN; 1.
DR Pfam; PF02170; PAZ; 1.
DR Pfam; PF02171; Piwi; 1.
DR SMART; SM01163; DUF1785; 1.
DR SMART; SM00949; PAZ; 1.
DR SMART; SM00950; Piwi; 1.
DR SUPFAM; SSF101690; PAZ domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50821; PAZ; 1.
DR PROSITE; PS50822; PIWI; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000472277};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 161..280
FT /note="PAZ"
FT /evidence="ECO:0000259|PROSITE:PS50821"
FT DOMAIN 466..767
FT /note="Piwi"
FT /evidence="ECO:0000259|PROSITE:PS50822"
SQ SEQUENCE 808 AA; 91788 MW; 068747AB011F578E CRC64;
MVQHFKVTIF GDRRPVYDGK RSLYTANPLP VATAGVDLDV TLPGEGGKDR PFKVSIKFVS
LVSWHMLHEV LTGRSVPEPL ELDKPISTNP VHAVDVVLRH LPSMKYTPVG RSFFSAPEGY
DHPLGGGREV WFGFHQSVRP AMWKMMLNID VSATAFYKAQ PVIQFMCEVL DIHNIDEQPR
PLTDSHRVKF TKEIKGLKVE VTHCGTMRRK YRVCNVTRRP ASHQTFPLQL ENGQTVERTV
AQYFREKYSL QLKYPHLPCL QVGQEQKHTY LPLEVCNIVA GQRCIKKLTD NQTSTMIKAT
ARSAPDRQEE ISRLVRSANY ESDPFVQEFQ FKVRDEMAHV TGRVLPAPML QYGGRVSTEH
FMQINRTTLW FQNRTVATPS HGVWDMRGKQ FHTGVEIKMW AIACFATQRQ CREEILKGFT
DQLRKISKDA GMPIQGQPCF CKYAQGADSV EPMFRHLKNT YSGLQLIIVI LPGKTPVYAE
VKRVGDTLLG MATQCVQVKN VVKTSPQTLS NLCLKINVKL GGINNILVPH QRPSVFQQPI
IFLGADVTHP PAGDGKKPSI AAVVGSMDAH PSRYCATVRV QRPRQEVIQD LASMVRELLI
QFYKSTRYKP TRIIFYRDGV SEGQFRQVLY YELLAIREAC IGLEKEYQPG ITYIVVQKRH
HTRLFCADRN ERVGRSGNIP AGTTVDTDIT HPYEFDFYLC SHAGIQGTSR PSHYHVLWDD
NCFTADEFQL LTYQLCHTYV RCTRSVSIPA PAYYAHLVAF RARYHLVDKE HDSAEGSHVS
GQSNGRDPQA LAKAVQIHHD TLRTMYFA
//
