ID A0A674KC07_9SAUR Unreviewed; 1595 AA.
AC A0A674KC07;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Multiple EGF like domains 6 {ECO:0000313|Ensembl:ENSTMTP00000031135.1};
GN Name=MEGF6 {ECO:0000313|Ensembl:ENSTMTP00000031135.1};
OS Terrapene triunguis (Three-toed box turtle).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Testudinoidea; Emydidae; Terrapene.
OX NCBI_TaxID=2587831 {ECO:0000313|Ensembl:ENSTMTP00000031135.1, ECO:0000313|Proteomes:UP000472274};
RN [1] {ECO:0000313|Ensembl:ENSTMTP00000031135.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [2] {ECO:0000313|Ensembl:ENSTMTP00000031135.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_026515719.1; XM_026659934.2.
DR Ensembl; ENSTMTT00000032263.1; ENSTMTP00000031135.1; ENSTMTG00000022390.1.
DR GeneID; 112112110; -.
DR CTD; 1953; -.
DR GeneTree; ENSGT00940000156971; -.
DR InParanoid; A0A674KC07; -.
DR Proteomes; UP000472274; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:TreeGrafter.
DR FunFam; 2.10.25.10:FF:000326; Multiple EGF like domains 6; 1.
DR FunFam; 2.170.300.10:FF:000002; Multiple epidermal growth factor-like domains 10; 6.
DR FunFam; 2.10.25.10:FF:001129; Predicted protein; 1.
DR FunFam; 2.10.25.10:FF:000010; Pro-epidermal growth factor; 1.
DR FunFam; 2.10.25.10:FF:000037; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.170.300.10:FF:000041; Tyrosine protein kinase receptor tie-1, putative; 2.
DR FunFam; 2.10.25.10:FF:000119; vitamin K-dependent protein S; 1.
DR FunFam; 2.10.25.10:FF:000240; Vitamin K-dependent protein S; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR PANTHER; PTHR24043:SF10; MULTIPLE EGF LIKE DOMAINS 6; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF00053; EGF_laminin; 6.
DR Pfam; PF14670; FXa_inhibition; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 33.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 23.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 18.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 15.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000472274};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1595
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025530758"
FT DOMAIN 29..110
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 109..144
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 187..227
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 311..351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 438..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 541..577
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 585..620
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 847..882
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 939..969
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 977..1012
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1020..1055
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1068..1098
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1106..1141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1279..1314
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1370..1400
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1451..1486
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 134..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 567..576
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 610..619
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 872..881
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 959..968
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1002..1011
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1045..1054
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1088..1097
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1131..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1304..1313
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1390..1399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1476..1485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1595 AA; 171574 MW; D421EC9F66E8E752 CRC64;
MELHVLVLSF ILTLPVSSFT YRNKLQPLMP NVCAEQELVI VGHRQPCVQA FTRMVKVWKQ
GCGGQLWCTG YERRTAYYTD YRQVYSMEYQ TVYKCCPGWS QLGGDAGCLY SVCNYGVCFN
GGNCMEGSSQ LCRCPSGFQG PRCQYDVNEC EASNGGCESQ CCNTIGSFYC KCPDGLRLKG
DGKACEDVDE CQVHNGGCQH RCVNTLGSYY CECKPGFRLH TDGRTCLAVN TCAVSNGGCE
HDCVQLTLTQ HQCRCRPNYH LKEDGKHCVL RNPCANRNGG CMHQCQNRRG IVHCECHPGY
RLAADSKACE DVDECATGLA VCAHSCLNTR GSFKCTCNPA YELGEDGKQC YRIEMEIVNS
CEANGGCSHL CRHTSSGPVC SCNFGYQLDE DQKTCIDIDD CDARSHCCQQ DCYNYPGGYE
CVCYAGYRLN TDGCGCDDVD ECSSNNGECE HTCQNLVGSF QCSCQIGYKL DEDRRSCIPL
DDPMEALDGQ RPIIRPIPHV AILRDEFTQL FDEEYEEEEE EVEARGEHTL SEKFVCLEDT
FGHDCSLTCD DCRNGGTCNE DQTGCDCPEG WSGVLCNQTC PEGTFGRNCS FTCHCKNGGT
CDPVTGKCRC PPGVSGELCE DGCPKGFFGK QCRKKCNCAN RGRCHRIYGA CLCDPGLYGR
YCHLACPKWA YGPGCSEECL CVQQNTQECD KKDGSCRCKP GYHGKRCQTK CDSGYYGGGC
KNKCSCPLGV SCDHVSGECQ KECPEGYHGE NCDQECPEGT FGVNCLQSCS CGSSPCDRLT
GTCICLPGRT GLDCGRACPA GRWGVGCQEI CLECENDASC DPATGACLCP PGYVGGRCQD
VCPAGWFGPG CQMRCSCGND GHCHPVTGKC SCAPGWTGDN CRRACDAGHW GPDCANTCNC
SNSDGSCNMR TGQCICEAGS TGLHCDQKCP EGWFGLSCRH RCQCDNGAVC DHVSGACTCS
PGWSGTFCER ACPDGFYGLE CQKTCTCLNG ARCDHVTGRC ICPAGWIGLH CNQTCEDHWY
GENCSQACSC FNDAICDHVS GQCLCAAGWT GATCQQACPY GFYGVNCHQH CLCRNGGTCD
PVTGHCTCLG GWTGLACELE CAQGRYGVDC QQACDCQNRG LCDHQTGHCI CRAGWTGQQC
QSACPEGTFG EHCAEQCACG DGVSCHHVTG VCDCPMGWRG QRCEKACLPG SFGKDCASRC
DCPPGTPCNH VTGQCGCPPG FMGHGCEQSC LPGTFGLNCA QACQCPEVNQ DCHPVTGACI
CAPGYHGRNC QLRCSAGWYG PNCERQCKCR NGGRCETTTG TCQCPAGYVG ADCSIGCPIG
RYGKDCRHLC SCGEGATCHH VTGICICPAG RTGASCEHVC QKNQYGAGCK QTCSCQNGGI
CHAADGSCLC GLGRTGKFCE LECPPGKYGA NCQLNCACRN NGTCDPVTGA CHCLRGHYGH
LCEHTCPPGF HGLRCQELCD CQNGATCDPV TGQCLCPAGF HKDRCQTGCE EGRYGERCQQ
LCDCEGNAPC DPVTGRCLCP PGKTGTKCDL DCRMDKFGPD CTLTCDCASV NSFCNAQNGQ
CTCIHGYIGP TCQEAVAARI SYLFSPRRAF QPVKH
//
