ID   A0A674KJA9_9SAUR        Unreviewed;       342 AA.
AC   A0A674KJA9;
DT   17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 1.
DT   28-JAN-2026, entry version 22.
DE   RecName: Full=Bardet-Biedl syndrome 5 protein homolog {ECO:0000256|PIRNR:PIRNR010072};
GN   Name=BBS5 {ECO:0000313|Ensembl:ENSTMTP00000032274.1};
OS   Terrapene triunguis (Three-toed box turtle).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Testudinoidea; Emydidae; Terrapene.
OX   NCBI_TaxID=2587831 {ECO:0000313|Ensembl:ENSTMTP00000032274.1, ECO:0000313|Proteomes:UP000472274};
RN   [1] {ECO:0000313|Ensembl:ENSTMTP00000032274.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2025) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSTMTP00000032274.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2025) to UniProtKB.
CC   -!- FUNCTION: Required for ciliogenesis. {ECO:0000256|PIRNR:PIRNR010072}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309, ECO:0000256|PIRNR:PIRNR010072}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome,
CC       centriolar satellite {ECO:0000256|ARBA:ARBA00004607}.
CC   -!- SIMILARITY: Belongs to the BBS5 family. {ECO:0000256|ARBA:ARBA00005822,
CC       ECO:0000256|PIRNR:PIRNR010072}.
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DR   RefSeq; XP_024063223.1; XM_024207455.2.
DR   AlphaFoldDB; A0A674KJA9; -.
DR   Ensembl; ENSTMTT00000033427.1; ENSTMTP00000032274.1; ENSTMTG00000023096.1.
DR   GeneID; 112111810; -.
DR   CTD; 129880; -.
DR   GeneTree; ENSGT00390000002753; -.
DR   InParanoid; A0A674KJA9; -.
DR   Proteomes; UP000472274; Unplaced.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0034464; C:BBSome; IEA:UniProtKB-UniRule.
DR   GO; GO:0034451; C:centriolar satellite; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   CDD; cd00900; PH-like; 1.
DR   FunFam; 2.30.29.30:FF:000232; Bardet-Biedl syndrome 5 isoform 1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR006606; BBL5.
DR   InterPro; IPR030804; BBS5/fem-3.
DR   InterPro; IPR014003; BBS5_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR21351:SF0; BARDET-BIEDL SYNDROME 5 PROTEIN; 1.
DR   PANTHER; PTHR21351; BARDET-BIEDL SYNDROME PROTEIN 5; 1.
DR   Pfam; PF07289; BBL5; 1.
DR   PIRSF; PIRSF010072; DUF1448; 1.
DR   SMART; SM00683; DM16; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR010072};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW   ECO:0000256|PIRNR:PIRNR010072};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR010072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000472274}.
FT   DOMAIN          29..83
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
FT   DOMAIN          159..213
FT                   /note="BBSome complex member BBS5 PH"
FT                   /evidence="ECO:0000259|SMART:SM00683"
SQ   SEQUENCE   342 AA;  38977 MW;  D1F06969E37B2E5C CRC64;
     MTSVLDALWE DRDVRFDISP QQMKMRPGEV LIDCLDSIED TKGNNGDRGR LLVTNLRIIW
     HSLALPRVNL SVGYNCIINI TTRTANSKLR GQTEALYILT KCNNTRFEFI FTNVVPGSPR
     LFTSVIAVHR AYETSKMYRD LKLRSALIQN KQLRLLPQEQ VYDKINGVWN LSSDQGNLGT
     FFITNVRIVW HANMNDSFNV SIPYLQIRSI KIRDSKFGLA LVIESSQQSG GYVLGFKIDP
     VEKLQEAVKE INSLHRVYSA SPIFGVDYEM EEKPQPLEDL TVEQVQDDVE IESDEQTDAF
     VAYFADGNKQ QDREPVFSEE LGLAIEKLKD GFTLQGLWEV MG
//