ID A0A674MVI7_TAKRU Unreviewed; 1601 AA.
AC A0A674MVI7;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Collagen alpha-1(XVIII) chain-like {ECO:0000313|Ensembl:ENSTRUP00000064988.1};
GN Name=LOC101069747 {ECO:0000313|Ensembl:ENSTRUP00000064988.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000064988.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000064988.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000064988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000064988.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_011604710.2; XM_011606408.2.
DR Ensembl; ENSTRUT00000064355.1; ENSTRUP00000064988.1; ENSTRUG00000029019.1.
DR GeneID; 101069747; -.
DR KEGG; tru:101069747; -.
DR GeneTree; ENSGT00940000165423; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1082; COLLAGEN TRIPLE HELIX REPEAT; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR Pfam; PF01392; Fz; 1.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1601
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025543543"
FT DOMAIN 171..289
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 42..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..128
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..138
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..626
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..669
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..719
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..761
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..845
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..946
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1028..1042
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1064
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1093
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1198
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1218
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1339
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1396..1409
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 186..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 1601 AA; 165005 MW; 9AE24BDF0E1EC0B6 CRC64;
MSRIQTLAIF LVLCTGTCES WFWSSNQEEK TTESPTEVLI TNASTTPAGP TSAAVTPTNA
TKEEEDDDLS GIGEELLDMA SGIRKFVEAW NATARNTHEV TEKVDPNRTG NANTSRGEGG
PEGSGSGSGP AADAGSSEES LMIVPNSTSV VGAAQRLSNY TKAPDGGRAD ASRPPCLPVP
SDWPICSAKR PQSLTLPNVF NHTSVDQVGA VLKEWAWLAR KGCHPSAEWF LCLLLAPRCS
APAPLPCRSF CQTLRDSCWA SLDNGRLPVE CHLLPDVAPG RSHPTCLSVS NWKAESGVSL
LQLIGDLPSG LNRSYGPRGQ VSFSFNAKAT AGQLALAHVP NPFYRHFSLI FNVRPSSPAA
AVLFSITDGP QKLVYVGVKL SGERAGRQKV QFFYTEPDSE ASYEAASFEV PSLANSWTRF
SLSIYEDQVT FYHGCESEPQ MVRFERSPDP MELDPEAKIF VGQAGNADAD RFRGDMSELK
VVGDPQAAER LCDDEDDSDT ASGDFGSGDG GVVKQTESTL KTTPPSFQPL PAPPVTASQR
LTGTIGEKGQ KGDRGERGSK GDLGLVGPKG EPGLGTRLSS ESGGPNGEKG SKGDKGQKGS
LGAGYAGKKG EPGVPGPPGL PGPPGPAATV VQRGNGSVVQ HEPGPIGPPG LPGLIGPVGP
PGSDGLPGDP GEDGKDGPPG PQGVPGTPGN PGSKGQKGDP GEGQPGPRGP PGLPGPPGPG
AGDRQTSTFF DMEGSGFSDM EKLRGAQGPP GPPGLPGPPG IPGTSVALGP NGAIGFGPPG
PPGLDGTPGL PGPPGPPGPR GQPGLVGVKG AQGAPGRVGS PGQTGLAGLP GPMGPAGPPG
PPGPPYRGGV GFGDQELEET TSLPGLAGPP GPQGPPGTAG FPGKPGFPGS NGEKGSEGPR
GPPGIPGIDG FPGQLGEKGD RGEKGERGQP GRDSGLPGPP GPPGPPGQII YQSSNDYNDV
YWSEGLQGGH GVPGRPGFPG PAGPKGERGD SGPPGYAPKG QKGEPGIIIG PDGSPQYHGG
LAGLPGESGP PGPVGPPGPY GPPGQKGEIG LPGRPGRPGL NGAKGLKGDS GSGSGYAYPG
PPGPPGPPGP PGASGPIDRI SGFEDIRRYL PDLKGEKGEQ GPPGRVEVSG SNFDINVLKN
EMKGETGSPG LKGEKGEQGS GYYDPRYGGS GYPGQPGPPG PKGDSVIGPP GPQGPPGQPG
RGYDGRPGPP GPPGPPGPAG GSYTGDSWDS RTVSVTGPPG PPGTPGLPGI SSGVSLFRTY
DTMAATARRH PEGSLVYVID QTDLYLRVRE GVRQVYLGNY IALPGDENEV AAVEPPPVVL
YSTDSNTPQP ESPVQPDPHP PIHHKPQDPH SQQPTHPDPH YHPDPRYPAP TDPRYPSYTE
RINRPDGRSS HTTQERPTYP YHRYPVTTPR RPPVPETPVH RHASGPGLHL IALNAPQTGA
MRGIRGVDYL CFTQAQAIGM KGTFRAFLSS RLQDLSSIVG KRDRDRLPII NLKDEVLFDS
WDAIFNDGRI KDNVPIYSFD GRDILSDGAW PEKMLWHGST GAGQRHTEDL CDAWRSGDQA
QNGMAAPLHA GSNPLQQRPG RCSSAYAVLC IENSYIGHAK R
//
