ID A0A674N8Y1_TAKRU Unreviewed; 543 AA.
AC A0A674N8Y1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 08-OCT-2025, entry version 24.
DE SubName: Full=Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 {ECO:0000313|Ensembl:ENSTRUP00000070184.1};
GN Name=kcnn4 {ECO:0000313|Ensembl:ENSTRUP00000070184.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000070184.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000070184.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000070184.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A674N8Y1; -.
DR Ensembl; ENSTRUT00000086633.1; ENSTRUP00000070184.1; ENSTRUG00000015090.3.
DR GeneTree; ENSGT00950000182904; -.
DR InParanoid; A0A674N8Y1; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 115..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 394..468
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
SQ SEQUENCE 543 AA; 61891 MW; E588F99783C07E24 CRC64;
MCDKREHVPG VRAPFRLCFP QLGRKAKGVP DRQDAAERRV TERGRPVCAL DMEMTNYDLP
GDSKLDCVNL GLISRNGRDS SKVSVPVTQR TGPMEGNNLY RLRDRKFLLE DKKRLCALAL
GTAVLGIVLM IVHAETCPFI DKTASHVFNC SISLSTACLL VLIIAFHYKD IRLFIIDHNQ
VDWRIAMTSQ RVLVITLELI VCVIHPIGTY RELSQHLNSS SPAPLCISNH RGEAFMDLEL
LLSMLMFLRL YLVHRTILLH SKVLLSASYR SIGSLNNINF TFRFVLKVLM NKYPGRTLLI
FIIFFWLTAS WMLTLCERKT IEVTGKMDTA LWLVAITFLT VGYGDVSPQT TCGKAVCLFT
GVMGVACTAM LVAVVTKTLE LNKGEKHVHL FMLDIQISKR IRHAAANVLR ECWLLHRTNL
KRGNRGEHRR HQRCLLEAIR VFRHLRLKQR KLRDYVSEMV DLPKVNGNSG WNILCMFHCR
AIEIPLKTLI SHAQAFYRLF IARCSDTLNA CLKISIKCPR IHLCAGFSGS ERFSMWDEFG
MCR
//
