ID A0A674NV85_TAKRU Unreviewed; 1605 AA.
AC A0A674NV85;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE SubName: Full=Collagen alpha-1(XVIII) chain-like {ECO:0000313|Ensembl:ENSTRUP00000077389.1};
GN Name=LOC101069747 {ECO:0000313|Ensembl:ENSTRUP00000077389.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000077389.1, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000077389.1, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000077389.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSTRUP00000077389.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_029696004.1; XM_029840144.1.
DR Ensembl; ENSTRUT00000073449.1; ENSTRUP00000077389.1; ENSTRUG00000029019.1.
DR GeneID; 101069747; -.
DR GeneTree; ENSGT00940000165423; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0031012; C:extracellular matrix; IEA:TreeGrafter.
DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1082; COLLAGEN TRIPLE HELIX REPEAT; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR Pfam; PF01392; Fz; 1.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
PE 4: Predicted;
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1605
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025625775"
FT DOMAIN 171..289
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 42..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..1103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1145..1254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..128
FT /note="Gly residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..138
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..626
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 652..669
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..719
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..761
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..800
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..860
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..961
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1046
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1047..1068
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1097
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1211..1222
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1343
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1413
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 186..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 1605 AA; 165042 MW; 486AA0E6AC517E4C CRC64;
MSRIQTLAIF LVLCTGTCES WFWSSNQEEK TTESPTEVLI TNASTTPAGP TSAAVTPTNA
TKEEEDDDLS GIGEELLDMA SGIRKFVEAW NATARNTHEV TEKVDPNRTG NANTSRGEGG
PEGSGSGSGP AADAGSSEES LMIVPNSTSV VGAAQRLSNY TKAPDGGRAD ASRPPCLPVP
SDWPICSAKR PQSLTLPNVF NHTSVDQVGA VLKEWAWLAR KGCHPSAEWF LCLLLAPRCS
APAPLPCRSF CQTLRDSCWA SLDNGRLPVE CHLLPDVAPG RSHPTCLSVS NWKAESGVSL
LQLIGDLPSG LNRSYGPRGQ VSFSFNAKAT AGQLALAHVP NPFYRHFSLI FNVRPSSPAA
AVLFSITDGP QKLVYVGVKL SGERAGRQKV QFFYTEPDSE ASYEAASFEV PSLANSWTRF
SLSIYEDQVT FYHGCESEPQ MVRFERSPDP MELDPEAKIF VGQAGNADAD RFRGDMSELK
VVGDPQAAER LCDDEDDSDT ASGDFGSGDG GVVKQTESTL KTTPPSFQPL PAPPVTASQR
LTGTIGEKGQ KGDRGERGSK GDLGLVGPKG EPGLGTRLSS ESGGPNGEKG SKGDKGQKGS
LGAGYAGKKG EPGVPGPPGL PGPPGPAATV VQRGNGSVVQ HEPGPIGPPG LPGLIGPVGP
PGSDGLPGDP GEDGKDGPPG PQGVPGTPGN PGSKGQKGDP GEGQPGPRGP PGLPGPPGPG
AGDRQTSTFF DMEGSGFSDM EKLRGAQGPP GPPGLPGPPG IPGTSVALGP NGAIGFGPPG
PPGLDGTPGL PGPPGPPGPR GQPGLVGVKG DSGNLGLPGI PGEKGAQGAP GRVGSPGQTG
LAGLPGPMGP AGPPGPPGPP YRGGVGFGDQ ELEETTSLPG LAGPPGPQGP PGTAGFPGKP
GFPGSNGEKG SEGPRGPPGI PGIDGFPGQL GEKGDRGEKG ERGQPGRDSG LPGPPGPPGP
PGQIIYQSSN DGGHGVPGRP GFPGPAGPKG ERGDSGPPGY APKGQKGEPG IIIGPDGSPQ
YHGGLAGLPG ESGPPGPVGP PGPYGPPGQK GEIGLPGRPG RPGLNGAKGL KGDSGSGSGY
AYPGPPGPPG PPGPPGASGP IDRISGFEDI RRYLPDLKGE KGEQGPPGRV EVSGSNFDIN
VLKNEMKGET GSPGLKGEKG EQGSGYYDPR YGGSGYPGQP GPPGPKGDSV IGPPGPQGPP
GQPGRGYDGR PGPPGPPGPP GPAGGSYTGD SWDSRTVSVT GPPGPPGTPG LPGISSGVSL
FRTYDTMAAT ARRHPEGSLV YVIDQTDLYL RVREGVRQVY LGNYIALPGD ENEVAAVEPP
PVVLYSTDSN TPQPESPVQP DPHPPIHHKP QDPHSQQPTH PDPHYHPDPR YPAPTDPRYP
SYTERINRPD GRSSHTTQER PTYPYHRYPV TTPRRPPVPE TPVHRHASGP GLHLIALNAP
QTGAMRGIRG VDYLCFTQAQ AIGMKGTFRA FLSSRLQDLS SIVGKRDRDR LPIINLKDEV
LFDSWDAIFN DGRIKDNVPI YSFDGRDILS DGAWPEKMLW HGSTGAGQRH TEDLCDAWRS
GDQAQNGMAA PLHAGSNPLQ QRPGRCSSAY AVLCIENSYI GHAKR
//
