ID A0A6A4QFC0_LUPAL Unreviewed; 2471 AA.
AC A0A6A4QFC0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 08-OCT-2025, entry version 22.
DE RecName: Full=Serine/threonine-protein kinase TOR {ECO:0000256|ARBA:ARBA00069838, ECO:0000256|RuleBase:RU364109};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513, ECO:0000256|RuleBase:RU364109};
GN ORFNames=Lalb_Chr05g0210831 {ECO:0000313|EMBL:KAE9612798.1};
OS Lupinus albus (White lupine) (Lupinus termis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX NCBI_TaxID=3870 {ECO:0000313|EMBL:KAE9612798.1, ECO:0000313|Proteomes:UP000447434};
RN [1] {ECO:0000313|Proteomes:UP000447434}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Amiga {ECO:0000313|Proteomes:UP000447434};
RX DOI=10.1038/s41467-019-14197-9;
RA Hufnagel B., Marques A., Soriano A., Marques L., Divol F., Doumas P.,
RA Sallet E., Mancinotti D., Carrere S., Marande W., Arribat S., Keller J.,
RA Huneau C., Blein T., Aime D., Laguerre M., Taylor J., Schubert V.,
RA Nelson M., Geu-Flores F., Crespi M., Gallardo-Guerrero K., Delaux P.-M.,
RA Salse J., Berges H., Guyot R., Gouzy J., Peret B.;
RT "Genome sequence of the cluster root forming white lupin.";
RL Nat. Commun. 11:492-492(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00048679};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00047899,
CC ECO:0000256|RuleBase:RU364109};
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031, ECO:0000256|RuleBase:RU364109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAE9612798.1}.
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DR EMBL; WOCE01000005; KAE9612798.1; -; Genomic_DNA.
DR OrthoDB; 381190at2759; -.
DR Proteomes; UP000447434; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR GO; GO:0031931; C:TORC1 complex; IEA:TreeGrafter.
DR GO; GO:0031932; C:TORC2 complex; IEA:TreeGrafter.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:InterPro.
DR GO; GO:0016242; P:negative regulation of macroautophagy; IEA:TreeGrafter.
DR GO; GO:0031929; P:TOR signaling; IEA:TreeGrafter.
DR CDD; cd05169; PIKKc_TOR; 1.
DR FunFam; 1.10.1070.11:FF:000017; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.20.120.150:FF:000001; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.25.10.10:FF:000265; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.25.10.10:FF:000284; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.25.10.10:FF:000288; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.25.10.10:FF:000474; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 1.25.10.10:FF:000802; Serine/threonine-protein kinase TOR; 1.
DR FunFam; 3.30.1010.10:FF:000006; Serine/threonine-protein kinase TOR; 1.
DR Gene3D; 1.20.120.150; FKBP12-rapamycin binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR050517; DDR_Repair_Kinase.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR009076; FRB_dom.
DR InterPro; IPR036738; FRB_sf.
DR InterPro; IPR057564; HEAT_ATR.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR024585; mTOR_dom.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR026683; TOR_cat.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF9; SERINE_THREONINE-PROTEIN KINASE MTOR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF08771; FRB_dom; 1.
DR Pfam; PF23593; HEAT_ATR; 1.
DR Pfam; PF11865; mTOR_dom; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01346; DUF3385; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM01345; Rapamycin_bind; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF47212; FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364109};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU364109};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364109};
KW Reference proteome {ECO:0000313|Proteomes:UP000447434};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|RuleBase:RU364109};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364109}.
FT DOMAIN 1298..1878
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2056..2373
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2439..2471
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2471 AA; 279053 MW; A47449FD5913BF67 CRC64;
MATSSQSHTH RYTAPPSVSG NFDTLNRILS DLCTRANPNE GSSLAFKKHL QQEQARDLTG
EVFSRFMEHL YDRISNLLDS TDVADNLGAL RAIDNLIDDS LGENASKVSR FTTYMRTVFD
SKRDPDILVH ASKVLGHFAR AGGAMTADEV ERQVQIALAW LRGTRLEYRR FAAVLILKEM
AENASTVFNV HVPEFVDAIW VALRDPALPV RERAVEALRA CLRVIEPRET RWRVQWYYRM
FEATQDGLGK NAPVHSIHGS LLAVGELLRN TGEFMMSRYR EVAEIVLRYL EHRDRLVRLS
ITSLLPRIAH FLRDRFVTNY LTICMNHILS VLKVPQDRDS GFIALGEMAG ALDGELIHYL
PTITTHLREA IVPRRSKPSL EALACVGSIA KAMGPATEPH VRGLLDIMFS TGLSTVLVEA
LEQICTSIPS LLSTIQDRLL DSISMVLSKS HYHLGRSVAS MSRGTTMNVP QHFSELSGSA
LVQLALQTLA RFNFKGHDLL EFVRESVVVY LDDEGRATRK DAALCCCKLV ANSFSGIMSI
HFGSSHLNRS GGGKRRRLVE ELVEKLLISA VADADVTVRH SIFTSLHGDR GFDEYLAQAD
NLSAVFAALN DEDFVVREYA ISLSGRLSEK NPAYVLPALR RHLIQLLTYL EQSADSKCKE
ESAKLLGCLI RNCERLILPY IAPVHKALVA RLNDVNASTG IVTGVLVTVG DLARVGGFAM
RQYIPELMPL IVEALLDGAS ISKREVAVAT LGQVVQSTGY VITPYNEYPQ LLVLLLKLLN
GILVWSTRRE VLKVLGIMGA LDPHMHKRNQ KSLPGPHGEV TRPSSDSNQQ IQTMDEFPAD
LWPSFASSDD YYSTVAINSL MRILRDPSLG IYHLKVIGSL MFIFKSMGLG CVPYLPKVLP
DLFHTVRTCD DSLKDFITWK LGTLVSIVRQ HIRKYLQDLL SLISEFWSLF TLPPSSRPRF
GYPVLHLVEQ LCLALNDEFR TYLPVILPGC IQVICDAERC NDYTYVLDIL HTLEVFGGTL
DEHMHLLLPA LIRLFKVDAS VDIRRAAIKT LTRLIPRVQV TGHISSLVHH LKLVLDGKND
ELRKDAIDAL CCLAHALGED FTIFIPSIHK LLLKYRLRHK EFEEIEGRLH RREPLILGAA
ASQRLNRRLP VEVISDPLED LENGPYEDGC DAHKLRDHQV NDGRLRTAGE ASQRSTKEDW
AEWMRHFSIQ LLKESPSPAL RTCARLAQLQ PFVGQELFAA GFVSCWAQLN ETSQKQLVRN
LEMAFSSPNI PLEILATLLN LAEFMEHDEK PLPIDIRLLG ALAEKCRAFA KALHYKEMEF
EGARSKKMDA NPVAVVEALI HINNQLHQHE AADGILTYAQ QHLDFQLKES WYEKLQRWDD
ALMAYTAKAS QATSQHLVLD ATLGRMRCLA ALARWEELNN LCREYWTPAE PAARLEMASM
AASAAWNMGE WEQMAEYVSR LDDGDETKLR GLGNTASGGD GSSNGTFFRA VLLVRIGKYD
EAREYVERAR KCLATELAAL VLESYERAYS NMVRVQQLSE LEEVIDYRTL PIGDRVAEER
RALIRNMWTQ RIQGAKSNVE VWQALLAVRA LVLPPMEDIE TWLKFASLCR KNGRISQARS
TLVKLLQFDP EISPENVRYH GPHQVMLAYL KYQWSLGEDS KRREAFIMLQ NLAMELSSAS
NIQPVTSSGF TNCLSPSVPL LARVYLTLGT WQWSLSPGLD DESLKDILDA FANATQYSNK
WAKAWHKWAL FNTAVMSHYT LRGFPDIAAQ FVVAAVTGYF HSIACAANAK GVDDSLQDIL
RLLTLWFNHG ATEEVQMALK KGFSLVNINT WLVVLPQIIA RIHSNNHAVR ELIQSLLVRI
GQNHPQALMY PLLVACKSIS NLRKAAAQEV VDKVRQRSGV LVDQAQLVSK ELIRVAILWH
ETWHEALEEA SRLYFGEHNI EGMLKVLEPL HEILEEGAMR NNVTLKERIF IEAYRQELLE
AYECCVNYKR TGKDAELTQA WDIYYHVFKK IDKQLQSLTT LDLESVSPEL LECRNLELAV
PGTYRAGAPV VTIASFARQL VVITSKQRPR KLTIHGSDGD DYAFLLKGHE DLRQDERVMQ
LFGLVNTLLE NSWKTAEKDL SIERYAVIPL SPNSGLIEWV PNCDTLHHLI REYRDARKIT
LNQEHKCMLS FAPDYDHLPL IAKVEVFQFA LDNTEGNDLA RVLWLKSRTS EIWLERRTNY
TRSLAVMSMV GYLLGLGDRH PSNLMLHRFS GKILHIDFGD CFEASMNREK FPEKVPFRLT
RMLEKAMEVS GIEGNFRSTC ENVMQVLRTN KDSVMAMMEA FVHDPLINWR LFNFNEIPQM
SMLTSNHVTP AVNTEESAQN RELPYPQRGA RERELLQAVN QLGDANEVLN ERAVVVMARM
SNKLTGRDFS TCSSVSNSSL QHAVDHNSLI SGDTREVDHA LSVKLQVQKL IDQAASHENL
CQNYVGWCPF W
//
