ID A0A6A5BDY0_NAEFO Unreviewed; 374 AA.
AC A0A6A5BDY0;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 02-APR-2025, entry version 18.
DE RecName: Full=Bromo domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=FDP41_005690 {ECO:0000313|EMBL:KAF0975277.1};
OS Naegleria fowleri (Brain eating amoeba).
OC Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC Vahlkampfiidae; Naegleria.
OX NCBI_TaxID=5763 {ECO:0000313|EMBL:KAF0975277.1, ECO:0000313|Proteomes:UP000444721};
RN [1] {ECO:0000313|EMBL:KAF0975277.1, ECO:0000313|Proteomes:UP000444721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30894 {ECO:0000313|EMBL:KAF0975277.1,
RC ECO:0000313|Proteomes:UP000444721};
RX PubMed=31690847;
RA Liechti N., Schurch N., Bruggmann R., Wittwer M.;
RT "Nanopore sequencing improves the draft genome of the human pathogenic
RT amoeba Naegleria fowleri.";
RL Sci. Rep. 9:0-16040(2019).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}.
CC -!- SIMILARITY: Belongs to the BORCS8 family.
CC {ECO:0000256|ARBA:ARBA00010463}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0975277.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; VFQX01000047; KAF0975277.1; -; Genomic_DNA.
DR RefSeq; XP_044559990.1; XM_044709242.1.
DR AlphaFoldDB; A0A6A5BDY0; -.
DR GeneID; 68112908; -.
DR VEuPathDB; AmoebaDB:FDP41_005690; -.
DR VEuPathDB; AmoebaDB:NF0056340; -.
DR VEuPathDB; AmoebaDB:NfTy_051030; -.
DR OMA; HIRRNIP; -.
DR OrthoDB; 10044187at2759; -.
DR Proteomes; UP000444721; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019320; BORCS8.
DR PANTHER; PTHR21146:SF0; BLOC-1-RELATED COMPLEX SUBUNIT 8; 1.
DR PANTHER; PTHR21146; MEF2B PROTEIN; 1.
DR Pfam; PF10167; BORCS8; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000444721}.
FT REGION 148..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..202
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..291
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..353
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 40956 MW; 3D6E87FF85575F8A CRC64;
MKQTQAPTHS GEIYKGSVPT LADSSDRFLD LDTKQSVVNL CNMWSSHIHH VMNEPSVGMY
RIVEHVRSKV PFIVEQKNLL KTKKVNEKIY DADYALLACK SINSNTPWIF SESIRLLKNN
FVSVPLAPPS TTTTNKSKVF SFHKSNATSA QQQIETTTTL PNDVSVSESL PSQNPTTNTV
QSSTTSDDQQ QQENPSEENQ PSVDTKSSVE ILTSPSYEQS SAIDNSDTHA SLNPTIKETT
EPLSPPKKEE STQDTMTQTT QEQAHSDTTT TSTLTNSNEE NIMTTTTTLT EASHPVVSPH
GETQDESSVT EVTGIPSSMT TGGGDDEWSS LAIQPLPSSS TKKKKATKKK KKQQASEEEP
AATEEEEALT PKTF
//
