ID A0A6A5F2T1_PERFL Unreviewed; 813 AA.
AC A0A6A5F2T1;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 28-JAN-2026, entry version 23.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=PFLUV_G00111410 {ECO:0000313|EMBL:KAF1385788.1};
OS Perca fluviatilis (European perch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Percoidei; Percidae; Percinae; Perca.
OX NCBI_TaxID=8168 {ECO:0000313|EMBL:KAF1385788.1, ECO:0000313|Proteomes:UP000465112};
RN [1] {ECO:0000313|EMBL:KAF1385788.1, ECO:0000313|Proteomes:UP000465112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:KAF1385788.1};
RA Roques C., Zahm M., Cabau C., Klopp C., Bouchez O., Donnadieu C., Kuhl H.,
RA Gislard M., Guendouz S., Journot L., Haffray P., Bestin A., Morvezen R.,
RA Feron R., Wen M., Jouanno E., Herpin A., Schartl M., Postlethwait J.,
RA Schaerlinger B., Chardard D., Lecocq T., Poncet C., Jaffrelo L.,
RA Lampietro C., Guiguen Y.;
RT "A chromosome-scale genome assembly of the European perch, Perca
RT fluviatilis.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF1385788.1}.
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DR EMBL; VHII01000009; KAF1385788.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A5F2T1; -.
DR Proteomes; UP000465112; Chromosome 9.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:UniProtKB-ARBA.
DR GO; GO:0048731; P:system development; IEA:UniProtKB-ARBA.
DR CDD; cd00054; EGF_CA; 4.
DR FunFam; 2.10.25.10:FF:000038; Fibrillin 2; 4.
DR FunFam; 2.10.25.10:FF:000020; Latent-transforming growth factor beta-binding protein 1; 1.
DR FunFam; 2.10.25.10:FF:000037; Signal peptide, CUB domain and EGF-like domain-containing 2; 1.
DR FunFam; 2.10.25.10:FF:000008; Signal peptide, CUB domain, EGF-like 2; 1.
DR FunFam; 2.10.25.10:FF:000240; Vitamin K-dependent protein S; 2.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000742; EGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR024731; NELL2-like_EGF.
DR InterPro; IPR052235; Nephronectin_domain.
DR InterPro; IPR049883; NOTCH1_EGF-like.
DR PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24050:SF28; UROMODULIN-LIKE; 1.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF25024; EGF_TEN; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00181; EGF; 17.
DR SMART; SM00179; EGF_CA; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 12.
DR PROSITE; PS01187; EGF_CA; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000465112};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..813
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025550613"
FT DOMAIN 121..162
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 163..209
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 210..251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 304..344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..385
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 386..426
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 552..583
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 584..614
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 646..678
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 680..712
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 715..747
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 51..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 220..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 555..565
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 573..582
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..596
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 604..613
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 650..660
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 668..677
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 684..694
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 702..711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 719..729
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 813 AA; 86191 MW; A98D5B5A1F6B331A CRC64;
MTPLRTLLSA LLLVLSVSEP LTSPEENEVL KHTEVELIKS QVTENAIRNL SETTPSHTPT
TAAPLTTTVS PSPSLAPQCM GNQVMLESST GCGCPSGMVR DGDNCTCPEG FTLEGAAGCK
DVDECEGEWP APCGLHARCT NTPGSYSCSC LRGYLMGAGG CQDIDECALA AVTGLQACQG
DAECKNTPGS FICSCPSGYV MALNGQSCVD VDECSFEEQC RRELGNVCVN THGSFVCQCQ
PGFRAEALAC IGPVCPDYTV CQDVDECTES PAVCDGHGVC ENTLGTYKCV CRPGYRGNGT
HCEDENECAS GGHGCDTNAR CGNIIGSYFC QCYQGFNGDG HSCFDIDECA LNNGHCQHNC
SNEPGGYSCR CASGYQLDQD GLNCTDVDEC LALNGTCKHI CVNTQGSFQC SCRPGYQLHI
DGHTCVDIDE CKLQSGGCSH TCTNTPGGHT CHCPPPLLLD TDNLTCSNVT SCKLRNGGCD
HICSVRAEGQ VQCTCRAGWK LDEDQRSCVD VNECGDFTNG GCEHLCVNHP GGFNCACRKG
YEVRTDDLTK CQPVCNPRCQ NYGVCVAPNS CDCPPGYPGL GCSAMCSPPC AHGGSCMRWN
KCLCPPGWTG AGCHTAVCEL PCANGGRCVG PDTCQCPSDY TGPQCLLPLC TPACQNGGRC
ADVDKCICVG GWQGARCQIE PVQCQTPCKN GGVCVGLNRC RCEKGFTGSL CETAVTTPCV
PPCQHGATCS PHNTCTCPEG TAGLRCERLT CPVVTTVVSM ARAVRKAFRE SYVDRCGPLG
VQLCTKYRMN QARVYLQAYR VGYKIQCPER KGR
//
