ID A0A6A7AZP2_9PLEO Unreviewed; 617 AA.
AC A0A6A7AZP2;
DT 17-JUN-2020, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 1.
DT 08-OCT-2025, entry version 17.
DE RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN ORFNames=T440DRAFT_189614 {ECO:0000313|EMBL:KAF2847615.1};
OS Plenodomus tracheiphilus IPT5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Leptosphaeriaceae;
OC Plenodomus.
OX NCBI_TaxID=1408161 {ECO:0000313|EMBL:KAF2847615.1, ECO:0000313|Proteomes:UP000799423};
RN [1] {ECO:0000313|EMBL:KAF2847615.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IPT5 {ECO:0000313|EMBL:KAF2847615.1};
RG DOE Joint Genome Institute;
RA Haridas S., Albert R., Binder M., Bloem J., Labutti K., Salamov A.,
RA Andreopoulos B., Baker S.E., Barry K., Bills G., Bluhm B.H., Cannon C.,
RA Castanera R., Culley D.E., Daum C., Ezra D., Gonzalez J.B., Henrissat B.,
RA Kuo A., Liang C., Lipzen A., Lutzoni F., Magnuson J., Mondo S., Nolan M.,
RA Ohm R., Pangilinan J., Park H.-J., Ramirez L., Alfaro M., Sun H., Tritt A.,
RA Yoshinaga Y., Zwiers L.-H., Turgeon B.G., Goodwin S.B., Spatafora J.W.,
RA Crous P.W., Grigoriev I.V.;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O; Xref=Rhea:RHEA:34287,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC ChEBI:CHEBI:57924; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00048233};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine + O2 = L-dopaquinone + H2O; Xref=Rhea:RHEA:18117,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC ChEBI:CHEBI:58315; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00048881};
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR EMBL; MU006324; KAF2847615.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6A7AZP2; -.
DR OrthoDB; 6132182at2759; -.
DR Proteomes; UP000799423; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR050316; Tyrosinase/Hemocyanin.
DR InterPro; IPR041640; Tyrosinase_C.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF76; SHKT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR Pfam; PF18132; Tyrosinase_C; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000799423};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..617
FT /note="tyrosinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025597687"
FT DOMAIN 92..340
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|Pfam:PF00264"
FT DOMAIN 455..580
FT /note="Tyrosinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18132"
SQ SEQUENCE 617 AA; 69404 MW; AF75959FEFF60AB0 CRC64;
MPMAWLSRCL LLVLVLSVVT CTELVQSRPL RARQAYGIVR GVVRGVNTTD EEGHVYVRRE
IRDLKTNYPD QWNLYLLALE SLQWTDQEDP YSYYGLAQIH GRPYKVWEDA PGLTHKLGTA
SYCPHSNQLF LGWHRPYIAL FEEILHEHMR NIASTAPLNR VERYEAAAHS FRMPYWDWGL
GGTAADVPDF FVNETIPLVE LDGSETVMAN PLHSYKFNPL VPEDFDDKWK QINKTVRWPE
SNNATAISRQ DIFVNTFKSQ STSLIGAVET AFRSSNFSQW AKQLEDPHGW MHGVIGGGWD
ETQSTTKFRG HMWPLEYSAF EPLFMLHHTN VDRLWALFQA IKPNATMGRS NIGPNGNVYL
EDDQYVNAST ELLPFRRASG AFWTTTDCHD TKVLGYAYPE TQSWNFASNS MYMANVTSTI
ARLYASKPRS LLVDSGQVAN SGMHASLDQD NTFTDWTIQS EAMASRLPST FVVRFSLVKP
GSSEHGIDVG TWMRLMPSTH DRMREREGAV PKTRAYAVDV VRGTTGLTTH LLDRIAAGEL
ASLKAGDVVP YLTERLAWKV FSGDGEQISG EALKAMKIEV ASSRARIPDD PGALVEYGED
LTRYPEITTG KPGGARG
//
