ID A0A6G0Y758_APHCR Unreviewed; 287 AA.
AC A0A6G0Y758;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 05-FEB-2025, entry version 13.
DE RecName: Full=Transcription initiation factor IIE subunit beta {ECO:0000256|PIRNR:PIRNR016398};
GN ORFNames=FWK35_00015335 {ECO:0000313|EMBL:KAF0750301.1};
OS Aphis craccivora (Cowpea aphid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Aphidomorpha;
OC Aphidoidea; Aphididae; Aphidini; Aphis; Aphis.
OX NCBI_TaxID=307492 {ECO:0000313|EMBL:KAF0750301.1, ECO:0000313|Proteomes:UP000478052};
RN [1] {ECO:0000313|EMBL:KAF0750301.1, ECO:0000313|Proteomes:UP000478052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=180601 {ECO:0000313|EMBL:KAF0750301.1};
RC TISSUE=Whole Body {ECO:0000313|EMBL:KAF0750301.1};
RA Voronova N.V., Shulinski R.S., Bandarenka Y.V., Zhorov D.G., Warner D.;
RT "Whole genome of Aphis craccivora.";
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Recruits TFIIH to the initiation complex and stimulates the
CC RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase
CC activities of TFIIH. Both TFIIH and TFIIE are required for promoter
CC clearance by RNA polymerase. {ECO:0000256|ARBA:ARBA00025581,
CC ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBUNIT: Tetramer of two alpha and two beta chains.
CC {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR016398}.
CC -!- SIMILARITY: Belongs to the TFIIE beta subunit family.
CC {ECO:0000256|PIRNR:PIRNR016398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0750301.1}.
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DR EMBL; VUJU01005778; KAF0750301.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6G0Y758; -.
DR OrthoDB; 5323195at2759; -.
DR Proteomes; UP000478052; Unassembled WGS sequence.
DR GO; GO:0005673; C:transcription factor TFIIE complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0001097; F:TFIIH-class transcription factor complex binding; IEA:TreeGrafter.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR CDD; cd07977; TFIIE_beta_winged_helix; 1.
DR FunFam; 1.10.10.10:FF:000177; Transcription initiation factor IIE subunit beta; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR040501; TFA2_Winged_2.
DR InterPro; IPR016656; TFIIE-bsu.
DR InterPro; IPR003166; TFIIE_bsu_DNA-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12716:SF8; TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA; 1.
DR PANTHER; PTHR12716; TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT; 1.
DR Pfam; PF18121; TFA2_Winged_2; 1.
DR Pfam; PF02186; TFIIE_beta; 1.
DR PIRSF; PIRSF016398; TFIIE-beta; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51351; TFIIE_BETA_C; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR016398};
KW Initiation factor {ECO:0000313|EMBL:KAF0750301.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR016398};
KW Protein biosynthesis {ECO:0000313|EMBL:KAF0750301.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000478052};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR016398};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR016398}.
FT DOMAIN 55..145
FT /note="TFIIE beta"
FT /evidence="ECO:0000259|PROSITE:PS51351"
FT REGION 25..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 33176 MW; E4E6BB47F3A855AF CRC64;
MDPALLRERE LFKLKASAIP VVEKRLREDT SNKDEIKRKS KPLPSMPRPP SPPNASSSLN
SYKSYGQSSQ YKFGVLTKIV KYIRARHQDG DDHPLTLDEL LDETNQLDVG TKVKMWLETE
ALPGNPKIER TSDGKYMFKP PYKLKDRKAL LKLLKQQDLK GLGGIMMDDI QESLPNCEKA
LKHLQNEILY VCRPGDKKKV MFYNDKSATI EINEEFKKMW RSIAVENMDD EKIEEHLEKQ
GISSMQDNGI KKVNHVKRKK PVTKKRLSKR PRDNEHLASV LEDYDTL
//
