ID A0A6G1BZV1_9ORYZ Unreviewed; 484 AA.
AC A0A6G1BZV1;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 28-JAN-2026, entry version 18.
DE RecName: Full=Arginase 1, mitochondrial {ECO:0000256|ARBA:ARBA00071872};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168};
DE AltName: Full=Arginine amidohydrolase 1 {ECO:0000256|ARBA:ARBA00078159};
GN ORFNames=E2562_023490 {ECO:0000313|EMBL:KAF0893237.1};
OS Oryza meyeriana var. granulata.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza meyeriana.
OX NCBI_TaxID=110450 {ECO:0000313|EMBL:KAF0893237.1, ECO:0000313|Proteomes:UP000479710};
RN [1] {ECO:0000313|EMBL:KAF0893237.1, ECO:0000313|Proteomes:UP000479710}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Menghai {ECO:0000313|Proteomes:UP000479710};
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF0893237.1};
RA Li W.;
RT "Whole genome sequence of Oryza granulata.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydrolysis of L-arginine to urea and L-
CC ornithine. The latter can be utilized in the urea cycle or as a
CC precursor for the synthesis of both polyamines and proline.
CC {ECO:0000256|ARBA:ARBA00058137}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginine + H2O = urea + L-ornithine; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00047391};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. Agmatinase subfamily.
CC {ECO:0000256|ARBA:ARBA00009227}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KAF0893237.1}.
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DR EMBL; SPHZ02000011; KAF0893237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A6G1BZV1; -.
DR OrthoDB; 288726at2759; -.
DR Proteomes; UP000479710; Unassembled WGS sequence.
DR GO; GO:0008783; F:agmatinase activity; IEA:TreeGrafter.
DR GO; GO:0004053; F:arginase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0033389; P:putrescine biosynthetic process from arginine, via agmatine; IEA:TreeGrafter.
DR CDD; cd11593; Agmatinase-like_2; 1.
DR FunFam; 3.40.800.10:FF:000007; Arginase 1, mitochondrial; 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR InterPro; IPR020855; Ureohydrolase_Mn_BS.
DR PANTHER; PTHR11358; ARGINASE/AGMATINASE; 1.
DR PANTHER; PTHR11358:SF26; GUANIDINO ACID HYDROLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00491; Arginase; 1.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS01053; ARGINASE_1; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003684};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000479710}.
FT REGION 73..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..85
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 52516 MW; E517DEBB911B6257 CRC64;
MGGVAAGTKW IHHVRRLSAA KVSSDALERG QSRVIDASLT LIRERAKLKV SIFTPFPPFP
FFLPPLTVPP VPLRPTPNSS PPCCPDAPDS TTPHPHPRCH ATPQLPHRRW PLVFPGAGRS
SAALPGATPT RLRRPWPPFG AAFFADGLPQ RPAPAAPVQP SPALYRAVPT RLISPPPPAC
NIVMENYYYV PVSAELLRAL GGVKASACLL GVPLGHNSSF LQGPAFAPPR IREAIWCGST
NSSTEEGKEL NDPRVLTDVG DVPIQEIRDC GVEDNRLMNV VSESVKTVME EDPLRPLVLG
GDHSISYPVV RAVSEKLGGP VDILHLDAHP DIYDAFEGNI YSHASSFARI MEGGYARRLL
QVGIRSITKE GREQGKRFGV EQYEMRTFSK DREKLESLKL GEGVKGVYIS VDVDCLDPAF
APGVSHIEPG GLSFRDVLNI LHNLQGDVVA GDVVEFNPQR DTVDGMTAMV AAKLVRELTA
RISK
//
