ID A0A6I3KSX2_9NOCA Unreviewed; 527 AA.
AC A0A6I3KSX2;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 28-JAN-2026, entry version 17.
DE RecName: Full=ferredoxin--NADP(+) reductase {ECO:0000256|ARBA:ARBA00013223};
DE EC=1.18.1.2 {ECO:0000256|ARBA:ARBA00013223};
GN ORFNames=GLP40_06495 {ECO:0000313|EMBL:MTE12431.1};
OS Nocardia aurantiaca.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Nocardiaceae; Nocardia.
OX NCBI_TaxID=2675850 {ECO:0000313|EMBL:MTE12431.1, ECO:0000313|Proteomes:UP000432464};
RN [1] {ECO:0000313|EMBL:MTE12431.1, ECO:0000313|Proteomes:UP000432464}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT2-14 {ECO:0000313|EMBL:MTE12431.1,
RC ECO:0000313|Proteomes:UP000432464};
RA Kanchanasin P., Tanasupawat S., Yuki M., Kudo T.;
RT "Nocardia sp. nov. CT2-14 isolated from soil.";
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 reduced [2Fe-2S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized
CC [2Fe-2S]-[ferredoxin] + NADPH; Xref=Rhea:RHEA:20125, Rhea:RHEA-
CC COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349; EC=1.18.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00047776};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:MTE12431.1}.
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DR EMBL; WMBB01000003; MTE12431.1; -; Genomic_DNA.
DR RefSeq; WP_328289792.1; NZ_WMBB01000003.1.
DR AlphaFoldDB; A0A6I3KSX2; -.
DR Proteomes; UP000432464; Unassembled WGS sequence.
DR GO; GO:0004324; F:ferredoxin-NADP+ reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR055275; Ferredox_Rdtase.
DR PANTHER; PTHR48467; GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE; 1.
DR PANTHER; PTHR48467:SF1; GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE; 1.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR PRINTS; PR00419; ADXRDTASE.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF51971; Nucleotide-binding domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000432464}.
FT DOMAIN 1..29
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 37..66
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 527 AA; 56644 MW; 555AF9D07F98F678 CRC64;
MPYVVTQSCC SDASCVYACP VNCIHPTPDE PDFLTAEMLY VDPRACVDCG ACATACPVDA
ITSSKKLTDE QLPFIEINAD FYRQERPRPL LARPIPAAEV KPGREPLRVA VIGSGPSAMY
AADELLTQPG VSVTVFDKVT RPYGLARFGV APDHTKTRQV RELFDVISAQ PGFGSYLNVN
VGLHVSHEEL LAHHHAVIYA VGASSDRKLG IPGEGLPGSV SATDFVAWYN GHPEQAGRFF
DLSHRRAVIV GNGNVALDVA RMLTADPELL VGTDVSQRAL NTLRRSNIEE VVILGRRGPA
ESAFTVPEFV GLLGADVDIV VEGEIPELVE GMSQKVEHKL KLLRGLADRP VAGRKRIVFR
YLSAPVAIAG VDRVTGIEMV RNELVTGDDG AVHAVATEAV ETLDAGLVLT SVGYRGMALP
GVPFDERDGV IPNLDGRVLE ESGGAVVPGA YVTGWIKRGP TGFIGTNKSC AQQTVRQLVD
DFNAGRLAQP ARSAADFDRL VGERQPHAIR GGAVNRPRRK LSLMVRR
//
