ID A0A6I6DT07_9MICO Unreviewed; 975 AA.
AC A0A6I6DT07;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 17.
DE SubName: Full=Na+/H+ antiporter subunit A {ECO:0000313|EMBL:QGU28115.1};
GN ORFNames=D7D94_10825 {ECO:0000313|EMBL:QGU28115.1};
OS Microbacterium oryzae.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC Microbacteriaceae; Microbacterium.
OX NCBI_TaxID=743009 {ECO:0000313|EMBL:QGU28115.1, ECO:0000313|Proteomes:UP000422989};
RN [1] {ECO:0000313|EMBL:QGU28115.1, ECO:0000313|Proteomes:UP000422989}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB-10 {ECO:0000313|EMBL:QGU28115.1,
RC ECO:0000313|Proteomes:UP000422989};
RA Das S.K.;
RT "Whole genome sequencing of Microbacterium oryzae strain MB-10T.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU000320}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP032550; QGU28115.1; -; Genomic_DNA.
DR RefSeq; WP_156242620.1; NZ_BAAAZL010000004.1.
DR AlphaFoldDB; A0A6I6DT07; -.
DR KEGG; moj:D7D94_10825; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000422989; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR050616; CPA3_Na-H_Antiporter_A.
DR InterPro; IPR007182; MnhB.
DR InterPro; IPR025383; MrpA_C/MbhD.
DR InterPro; IPR046806; MrpA_C/MbhE.
DR InterPro; IPR001750; ND/Mrp_TM.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; NF009284; PRK12644.1; 1.
DR PANTHER; PTHR43373; NA(+)/H(+) ANTIPORTER SUBUNIT; 1.
DR PANTHER; PTHR43373:SF1; NA(+)_H(+) ANTIPORTER SUBUNIT A; 1.
DR Pfam; PF13244; MbhD; 1.
DR Pfam; PF20501; MbhE; 1.
DR Pfam; PF04039; MnhB; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000422989};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 73..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..310
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 316..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 621..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..664
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 744..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 927..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..106
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 125..410
FT /note="NADH:quinone oxidoreductase/Mrp antiporter
FT transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT DOMAIN 605..668
FT /note="MrpA C-terminal/MbhD"
FT /evidence="ECO:0000259|Pfam:PF13244"
FT DOMAIN 684..758
FT /note="MrpA C-terminal/MbhE"
FT /evidence="ECO:0000259|Pfam:PF20501"
FT DOMAIN 824..946
FT /note="Na+/H+ antiporter MnhB subunit-related protein"
FT /evidence="ECO:0000259|Pfam:PF04039"
SQ SEQUENCE 975 AA; 103582 MW; 0B9A88F00C952E7A CRC64;
MLVLLALFAG GSLLLPVLAK WLGARVFWVG ALFPLAAFVH ALAITPHDGS IPFESYSWIG
PLDVVISMRM DTLSWLLTLV VTGVGTLVMA YCRVYFRGKD AGLGQFSAVL LAFAGAMYGL
VLTDDAVMLV MFWEVTSILS YLLIGHYHTR AASRRAALQA LLVTTLGGLV MFIGMVILIV
ETGTTSISRM LELAPTGALV DVALVLLLVG AVSKSALFPF HFWLPGAMAA PTPVSAYLHA
AAMVKAGIYL LARFAPTFAE AGPWRPIVIV LGVVTMLLGG VQALRETDLK RILAFGTVSQ
LGFISTIIGY GGRDTALAGV ALLLAHALFK SSLFLVVGVI DRQLSTRDIR RLSGVGRQAP
TMAAMSMVAI ATMAGLPPTL GFVAKEAAFT ALLDEALAGS AWALVALIGV VIGSALTLAY
GLRFLWGAFW TKRDPEGRLR EDTPWPDPPI GFLTSPLVLA ALALAGGLVA PLLDALLADY
ADTAIGEGHY HLALWHGWEP ALLLSLVTVV GGAAIFWLVR VTRWDVRGRV LPFQAADLYY
ASTRGVDRLS VAVTSLTQRG SLPLYVGTIF VVLVAAEASV LLAGGEWRAE LDAWQHPVQL
ALAPLMIVAG FLAVRARKRY TGVVLVSATG LGMVVLFAVE GAPDLALTQV LVESVTLIAF
ALVLRRLPSR LGTHNDSVAP VARAILAIAA GVTMAVVAVI ASSARIHEPV STAWTELAYE
IGHGRNVVNV ALVDLRGWDT MGELSVLVLA ATGVASLVFV TDRADSLHRI ARRLPRSARR
AARRRLLVET TGGIRVENAE NREHPRAWLV GGQRMSAESR SILLEMIVRI LFHTIIVVSL
YLLFAGHNLP GGGFAGGLVA GMALVMRYVA GGRYELGVAA PGDAGQLLGF GMVLAVGTAV
VPVLFGLDPL TRGVWEADLP LLGHVEFVTS TIFDIGVYLV VIGLVLDVLR SLGAEVDRQL
REERRAAAEQ GSATT
//
