ID A0A6I6NB74_9ACTN Unreviewed; 497 AA.
AC A0A6I6NB74;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 28-JAN-2026, entry version 21.
DE RecName: Full=GTPase HflX {ECO:0000256|HAMAP-Rule:MF_00900};
DE AltName: Full=GTP-binding protein HflX {ECO:0000256|HAMAP-Rule:MF_00900};
GN Name=hflX {ECO:0000256|HAMAP-Rule:MF_00900,
GN ECO:0000313|EMBL:QHA07260.1};
GN ORFNames=GQF42_31680 {ECO:0000313|EMBL:QHA07260.1};
OS Streptomyces broussonetiae.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2686304 {ECO:0000313|EMBL:QHA07260.1, ECO:0000313|Proteomes:UP000436138};
RN [1] {ECO:0000313|EMBL:QHA07260.1, ECO:0000313|Proteomes:UP000436138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T44 {ECO:0000313|EMBL:QHA07260.1,
RC ECO:0000313|Proteomes:UP000436138};
RA Mo P.;
RT "Streptomyces sp. strain T44 isolated from rhizosphere soil of Broussonetia
RT papyrifera.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase that associates with the 50S ribosomal subunit and may
CC have a role during protein synthesis or ribosome biogenesis.
CC {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SUBUNIT: Monomer. Associates with the 50S ribosomal subunit.
CC {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00900}.
CC Note=May associate with membranes. {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. HflX GTPase family. {ECO:0000256|HAMAP-Rule:MF_00900}.
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DR EMBL; CP047020; QHA07260.1; -; Genomic_DNA.
DR RefSeq; WP_158925575.1; NZ_CP047020.1.
DR AlphaFoldDB; A0A6I6NB74; -.
DR KEGG; sbro:GQF42_31680; -.
DR Proteomes; UP000436138; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043022; F:ribosome binding; IEA:TreeGrafter.
DR CDD; cd01878; HflX; 1.
DR FunFam; 3.40.50.11060:FF:000001; GTPase HflX; 1.
DR FunFam; 3.40.50.300:FF:000690; GTPase HflX; 1.
DR Gene3D; 6.10.250.2860; -; 1.
DR Gene3D; 3.40.50.11060; GTPase HflX, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00900; GTPase_HflX; 1.
DR InterPro; IPR030394; G_HFLX_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR032305; GTP-bd_M.
DR InterPro; IPR016496; GTPase_HflX.
DR InterPro; IPR025121; GTPase_HflX_N.
DR InterPro; IPR042108; GTPase_HflX_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03156; GTP_HflX; 1.
DR PANTHER; PTHR10229:SF0; GTP-BINDING PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10229; GTP-BINDING PROTEIN HFLX; 1.
DR Pfam; PF16360; GTP-bdg_M; 1.
DR Pfam; PF13167; GTP-bdg_N; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PIRSF; PIRSF006809; GTP-binding_hflX_prd; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51705; G_HFLX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00900};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_00900}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00900}; Reference proteome {ECO:0000313|Proteomes:UP000436138}.
FT DOMAIN 275..437
FT /note="Hflx-type G"
FT /evidence="ECO:0000259|PROSITE:PS51705"
SQ SEQUENCE 497 AA; 54265 MW; 171D77E39324E8D7 CRC64;
MTSSSSSSQD TKRLAHTYPE GLRADALMEE DVAWSHEIDG ERDGDQFDRS ERAALRRVAG
LSTELEDVTE VEYRQLRLER VVLVGVWTTG TVQDADNSLA ELAALAETAG ALVLDGVIQR
RDKPDAATYI GSGKAQELRD IVLETGADTV ICDGELSPGQ LIQLEDVVKV KVIDRTALIL
DIFAQHAKSR EGKAQVALAQ MQYMLPRLRG WGQSLSRQMG GGKGGGLATR GPGETKIETD
RRRIREKMAK MRREIAEMKT GREIKRQERR RNKVPSVAIA GYTNAGKSSL LNRLTGAGVL
VENALFATLD PTVRRAETPS GRLYTLADTV GFVRHLPHHL VEAFRSTMEE VGDSDLILHV
VDGSHPVPEE QLAAVREVIR DVGATDVPEI VVINKADAAD PLVLQRLLRN EKRSLAVSAR
TGLGIEELLA LIDNDLPRPA VEIEALVPYT HGKLVARAHS EGEVISEEHT AEGTLLKVRV
HEELAADLAP YVPVSAA
//
