ID A0A6I8MZA9_ORNAN Unreviewed; 1342 AA.
AC A0A6I8MZA9;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 28-JAN-2026, entry version 24.
DE SubName: Full=Collagen type XVIII alpha 1 chain {ECO:0000313|Ensembl:ENSOANP00000034019.1};
GN Name=COL18A1 {ECO:0000313|Ensembl:ENSOANP00000034019.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000034019.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000034019.1, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000034019.1,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000034019.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000034019.1};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSOANP00000034019.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000034019.1};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the multiplexin collagen family.
CC {ECO:0000256|ARBA:ARBA00061275}.
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DR RefSeq; XP_039768565.1; XM_039912631.1.
DR Ensembl; ENSOANT00000063071.1; ENSOANP00000034019.1; ENSOANG00000043147.1.
DR GeneID; 120638499; -.
DR CTD; 80781; -.
DR GeneTree; ENSGT00940000158212; -.
DR Proteomes; UP000002279; Chromosome 7.
DR Bgee; ENSOANG00000043147; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00247; Endostatin-like; 1.
DR FunFam; 3.10.100.10:FF:000008; collagen alpha-1(XVIII) chain isoform X1; 1.
DR FunFam; 3.40.1620.70:FF:000003; Collagen type XVIII alpha 1; 1.
DR FunFam; 2.60.120.200:FF:000039; Collagen XV alpha 1 chain; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.1620.70; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR050149; Collagen_superfamily.
DR InterPro; IPR010515; Collagenase_NC10/endostatin.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR045463; XV/XVIII_trimerization_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1082; COLLAGEN TRIPLE HELIX REPEAT; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF20010; Collagen_trimer; 1.
DR Pfam; PF06482; Endostatin; 1.
DR SMART; SM00210; TSPN; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1342
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5026136946"
FT DOMAIN 30..218
FT /note="Thrombospondin-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00210"
FT REGION 222..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..1013
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..235
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..459
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..501
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..611
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..682
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..837
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..982
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1006
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1342 AA; 137804 MW; BFD5B353D47C0178 CRC64;
MPARWPLLLA GLLAFLPLSA AQDPENFSNE VGLLQLIGEP PPKQITQVYD AATGLGYVFG
PDANSGQVAR YYVPNPFYKD FSLIFHVKPT TDGPGMLFAL TDATQSLIFV GVKLSKATDG
KQRVIFYYTE PGSESSVVAA RFRQPLPARQ WNRFAVGVEN MEAVLYVNCQ EVERVSFERS
PDDLVLEAGS GLFVAHAGGA DPDKFQGVIA ELKVRGDPQV TSLQCLDDDD DDDSDGSSGD
YGSGLEDKQD HPRREPASPL IPDLPEAPPV TSPPLAGTAV QEEGESEADS QPGQLEEEEG
NLASSGGQSH PKGDKEKKVE HGPEGSEGNL EEVGKSQENL GFGHASTKGQ KGEPGARGEP
GPMGPQGPAG SVLQGPGDPN VEQVSGPQGP PGPTGSPGID GSPGKDGEPG VPGEDGKPGD
IGPQGFPGTP GDIGPKGDKG DPGVGPRGPP GPPGPPGPPG SSSKTDKLTF IDMEGSGFGG
DLESLRGPRG FPGPPGPPGV PGLPGEPGRF GTNGTDTPGP PGLPGLPGRD GAPGPQGPPG
PPGPPGKVGN QGEMGLKGED GVIGLPGAPG LKGSKGEDGP VGKPGEAGAV GQPGPIGPPG
QPGPPGPPGL PAPGFGAGFD DMEGSGIPFL TGGPQGPPGL PGLKGDDGIP GIAGPPGEKG
DHGAPGLPGQ PGMEGPEGPQ GSKGDKGSPG EKGEPGKDGV GHPGLPGPPG PPGRMVYVSP
EYGSTGPKGD LGTKGYWGTP GPKGEKGEPG MVVGSDGMVL APGQKGNKGD PGFRGPPGPY
GRPGHKGEIG FPGRPGRPGM NGLKGEKGEP ADVSGGFGFR GLPGLPGPPG PPGPPGASVP
LYDSNAFGET GPAGPPGLPG FPGTPGQKGE KGDIGPAGPP GPFPYDFSHF GTSVKGEKGA
RGDAGQKGER GEPGSGGFFG SSAAGPPGPP GPQGYPGIPG PKGDSIRGQP GPPGPQGPPG
IGYEGRQGPP GPPGPPGPPS FPGPHRQTIT VPGPPGPPGP PGPPGTTGPS SGQLRILSTY
QAMLNKAREL PEGWVIFVAD REELYVRVRN GIRKIMLEAQ IPLPQGSENE VAVVQPPVFQ
YPQSGSQFND GNNPYPRREH PYSTAKPWRS DDILPGYPRY PDQSNSRHNY HGAQHHQEHQ
HSLYPNLRPQ YPIPSAVHTH HDFQPALHLI ALNTPLSGSM RGIRGADFQC FQQAREVGLT
GTFRAFLSSR LQDLYSIVRR ADRNGVPIVN LKDELLFNNW EALFSGSEGQ LKPGSRIFSF
DGKDVLRHSS WPQKSVWHGS DSKGRRLTEN YCETWRTDEA MVTGQASSLM SGKLLEQKPM
SCRNAFVVLC IENSFMTSLS KK
//
