ID   A0A6I8N9W7_ORNAN        Unreviewed;       823 AA.
AC   A0A6I8N9W7;
DT   12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT   12-AUG-2020, sequence version 1.
DT   18-JUN-2025, entry version 21.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN   Name=OSBPL6 {ECO:0000313|Ensembl:ENSOANP00000037942.1};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000037942.1, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000037942.1}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000037942.1};
RG   Ensembl;
RL   Submitted (MAR-2025) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm, cytosol {ECO:0000256|ARBA:ARBA00004514}. Endoplasmic
CC       reticulum membrane {ECO:0000256|ARBA:ARBA00004586}.
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000256|ARBA:ARBA00008842,
CC       ECO:0000256|RuleBase:RU003844}.
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DR   AlphaFoldDB; A0A6I8N9W7; -.
DR   Ensembl; ENSOANT00000065828.1; ENSOANP00000037942.1; ENSOANG00000008628.4.
DR   GeneTree; ENSGT00940000156791; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000008628; Expressed in fibroblast and 8 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:UniProtKB-ARBA.
DR   CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR   FunFam; 2.30.29.30:FF:000011; Oxysterol-binding protein; 1.
DR   FunFam; 2.40.160.120:FF:000001; Oxysterol-binding protein; 1.
DR   FunFam; 3.30.70.3490:FF:000002; Oxysterol-binding protein; 1.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041680; PH_8.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF76; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 6; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   Pfam; PF15409; PH_8; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT   DOMAIN          52..147
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   COILED          348..382
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   823 AA;  93968 MW;  7007EC09B1475FD8 CRC64;
     GGYILERNAS AGHEPSVSRQ FLETEPVSLS KEADSWEIIE GLKIGQTNVQ KPDKHEGFML
     KKRKWPLKGW HKRFFVLDNG MLKYSKAPMD IQKGKVHGSI DVGLSVMSIK KKARRIDLDT
     EEHIYHLKVK SQDWFDAWVS RLRHHRLYRQ NEIVRSPRDA SFHIFPSTST TESSPAANMA
     MVDGKVQPNS FLWQPPLPCS SSLPATCTSG QSKVVAWLQD SEEMDRCAED LAHCQSNLVE
     LSKLLQNLEI LQRTQSAPNF TDMQVPFSAT MSPVRLHSSN PNLCADIEFQ TPPSHLADPL
     ESSTDYTKLQ EEFCLIAQKV HSLLKSAFNS IAIEKEKLKQ MVSEQDLNKG HSAQMARLRQ
     SLSQALNQNA ELRSRLNRIH SESVICDQVV SVNIIPSPDE ASDDESYISD VSDNISEDNT
     SVADNISRQI LNGELTGGAF RNGRRTCLPA PCPDTSNINL WNILRNNIGK DLSKVSMPVE
     LNEPLNTLQH LCEEVEYSEL LDKASETDDA YERMVLIAAF AVSGYCSTYF RAGSKPFNPV
     LGETYECIRE DKGFRFFSEQ VSHHPPISAC HCESKNFVFW QDIRWKNKFW GKSMEILPVG
     TLNVMLPKYG DYYVWNKVTT CIHNILSGRR WIEHYGEVTI RNTKSSVCIC KLTFVKVNYW
     NSNVNEVQGV VMDQEGKVVH RLFGKWHEGL FCGVAPSAKC IWRPGSMPTN YELYYGFTRF
     AIELNELDPV LKDLLPPTDA RFRPDQRFLE EGDLEAAASE KQRVEELQRS RRRYMEENHL
     EHIPKFFKKV TDANQREAWV SNDTYWGLRK EPGFSKVESP VLW
//