ID A0A6I8NK50_ORNAN Unreviewed; 4160 AA.
AC A0A6I8NK50;
DT 12-AUG-2020, integrated into UniProtKB/TrEMBL.
DT 12-AUG-2020, sequence version 1.
DT 18-JUN-2025, entry version 22.
DE SubName: Full=Dynein axonemal heavy chain 11 {ECO:0000313|Ensembl:ENSOANP00000041046.1};
GN Name=DNAH11 {ECO:0000313|Ensembl:ENSOANP00000041046.1};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000041046.1, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000041046.1}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000041046.1};
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSOANT00000064780.1; ENSOANP00000041046.1; ENSOANG00000011810.3.
DR GeneTree; ENSGT00940000158880; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000011810; Expressed in endometrium and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-ARBA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR FunFam; 1.10.287.2620:FF:000001; Cytoplasmic dynein heavy chain 1; 1.
DR FunFam; 3.40.50.300:FF:000667; Dynein axonemal heavy chain 11; 1.
DR FunFam; 1.20.1270.280:FF:000003; Dynein axonemal heavy chain 17; 1.
DR FunFam; 1.20.920.20:FF:000003; Dynein axonemal heavy chain 17; 1.
DR FunFam; 1.20.920.30:FF:000003; Dynein axonemal heavy chain 17; 1.
DR FunFam; 3.10.490.20:FF:000002; Dynein axonemal heavy chain 17; 1.
DR FunFam; 3.40.50.300:FF:000219; Dynein axonemal heavy chain 17; 1.
DR FunFam; 1.10.8.1220:FF:000001; Dynein axonemal heavy chain 5; 1.
DR FunFam; 3.20.180.20:FF:000001; Dynein axonemal heavy chain 5; 1.
DR FunFam; 3.40.50.300:FF:002141; Dynein heavy chain; 1.
DR FunFam; 1.10.8.710:FF:000002; dynein heavy chain 17, axonemal; 1.
DR FunFam; 1.20.140.100:FF:000001; dynein heavy chain 17, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000411; dynein heavy chain 17, axonemal; 1.
DR FunFam; 1.10.8.720:FF:000002; Dynein heavy chain 9, axonemal; 1.
DR FunFam; 1.20.58.1120:FF:000002; Dynein heavy chain 9, axonemal; 1.
DR FunFam; 3.40.50.300:FF:000049; Dynein, axonemal, heavy chain 5; 1.
DR FunFam; 1.10.472.130:FF:000001; Dynein, axonemal, heavy chain 9; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF12; DYNEIN AXONEMAL HEAVY CHAIN 11; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1564..1700
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2169..2319
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2505..2612
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2764..2798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2978..3005
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4160 AA; 479077 MW; 61364A6CE36BC445 CRC64;
GLLFLLTKVE KISFAPETLI FSCFLNLSTI LQVLVPILTN KKNHALWPRF ISQDLEHHME
ILKNKIHIVR GLVLGRTFLP IPSIIRKINV DQSDQETKIV LHAIESGVIK WSHQICAILK
EDSVQPLLNG LHSTPQTELD FWKARKDHFL YSFQNYFSFR PLLFRKWLRS LKPNGASYFP
TFKNIFRDFW LKLKDIDLYL RPLKKHVQCL QETKFPQTRI LIHPLLHTIC LLWSHSEFYG
YPARIIVLLQ EFCNLFIDQV GFSFQSQPFP SGKSQIVSTR EELLSLENLG REPLSLPTSP
VKEGTQILNK NMPFTSGTLK WAKEIQDRIQ AFWCNLAHLH HPILEGPDAV LVFQKYSEML
TLLDQHTNQV FGEWKREVDE ICAFNLHQPL IKRDAVNGLL RVNFDPQLVA VLREVKYLLM
LKQPDIPNSA LSIFERRNTF LKYVRSLELL VQCYNKLKTT LLEAEYPLIE DELGAIDEQL
KKAERSFTWQ EESSWKYIEA MKSTICGLEQ RVQQARDNIT TIQRMMEAWG EQSLFSQKDS
RRETLFSLED KQDRFIKKYK LIQEGGYKIH GLVEVSSLDT WKIYIEFIDD IVVDGFFNAI
MSDLDFFMVN TQKSLRPAPF LQIQMMLQAP EVIFKPSLEK DIGDGFYDLV EDLLCNIFKM
SAQMKRIASH LEAPNYQVFS CLNDMDNMFN LVEVRKKILD RVAGATSQVL EYRNSLETYS
HLWVDDRIEC MKQFLLYGRL LTPEELNDQA NKDIPQQSPT IEQFKAQIDI YEALYVRISK
FDDFRVFDSW LRVDMKPFKM SLLNLTKKWS WMFQEHLLRF VNDRLTDLEE FIQVTDAGLQ
REVNEGDYSA LIEIMGQLLA VRHQQRAIDE LFEPLRATVA LLESYGLEMA DQVYVQLEKL
PERWSATKKI ADGVKHQVAP LQTAEVTVIK RRCAVFDAKQ MEFRKRFKKD APFDFNVQSP
YKILDKANEE LETLEGEMLQ IQDSTILFEV PFPDYKQVKQ CRKEIKLLKD LWDINTYVKS
SIDDWTKTQW RQINVEQMDV ELRKFAKDIR SLDKDVRLWD AYLGLELTVK NVMTSLRAIA
ELQNPAIRDR HWHQLMKATG VSMTLGDLLG LHLHQVEDQV QCIVDKAVKE LGTEKILTDI
SYTWAMLEFS YEEHHRTGIP LLKSDEQLFE TLDHNQVQLQ TILQSKYVEY FIDQVSSWQK
KLTVTDSVIF IWMDVQRTWS HLESIFVGSK DIKFQLPADV RRFEGINADF EELMIDTVKI
KNVLKATCRP HLFEKLEDLQ HRLSLCEKAL AEYLESKRLA FARFYFISSA DLLDILSKGS
QPRQVTCHLA KLFDSVADLQ FEDYQQMLTN TATGMFSKEK ESVPFHAACD CVGQVETWLK
RLEGTMRETV RRSIPEATAA YEEKPREQWI FDFPAQAVLT SSQIWWTTDV GIAFSRLEEG
FETALKDYHK KQIAQLNALI ALLLGELAPG DRQKIMTVCT IDVHARDVVA KLVAQKVTSS
QAFAWLSQLR HRWDDIQKHY YVNICDAQFQ YCYEYLGNSP RLVITPLTDR CYITLTQALH
LKMSGAPAGP AGTGKTETTK DLGRALGMMV YVFNCSEQMD YKSIGNIYKG LAQTGAWGCF
DEFNRIAVEV LSVVAVQVKM IHDAIRKKKD RFFFLGEEIT LKSSIGIFIT MNPGYAGRTE
LPENLKTLFR PCAMVVPDIE LICEIMLVAE GFVNARLLAR KFITLYTLCK ELLSKQDHYD
WGLRAVKSVL VVAGSLKRGD KNRPEDQVLM RALRDFNMPK IVTDDIPIFM GLISDLFPAL
DVPRKRELQF EQMVRLSTLE LHLQPEESFI LKVVQLEELL AVRHCVFVIG NAGTGKSEIL
KTLNRTYVNL KRKPIWSDIN PKAVTTDELF GFIHHATREW KDGLFSSLLR EQANIIHEGP
KWIILDGDID PMWIESLNTV MDDNKILTLA SNERVALTPS MRLLFEIPHL KTATPATVSR
AGILYVNPQD LGWNPYVSSW IDGRSHQSEK ANLTILFDKY IPPCLEKLRT SFKTITSIPE
NSMVQSLCSL LDCLLTPENV PSDSPREVYE LYFVFACVWA FGGALFQDQL SDYPGEFSRW
WLKEMKTVKY PSQGTIFDYY LDHKTRKFLP WMDKVPKFIM DMNTPLQAVL AHTAETTRLK
YFTDLLLEAG KPIMLVGNAG VGKTVFVGDT LAHLSEDYTV AKVPFSYYTT SAVLQRILEK
PLEKKAGRNY GPIGNKKLIY FIDDFNMPEV DIYGTVQTHT LIRQHIDSGH WYDRQKMTLK
EIHNCQYITC MNPTAGSFTI NPRLQRHFTV FAIHFPSPEA LHSIYSQILK FHFHQHRFST
SVLKNVPALI QATAALHQMM VQNFLPTAVK FHYIFNLRDI SNIFQGILFG TPECLKEPND
FLRLWLHESS RVYGDKMVDS KDSDLFHKKL LATAHKHFER PLIYCCYANG LRDPRYLPVK
DWEGLKKILT EALESYNELN AAMSLVLFED AMQHVCRIIR ILGTPQVNAL LIGVGGSGKQ
SLSRLAAFIC SFEVFQITLR KDYGIQDLKV DLANLYIRAG AKNMPTVFLL TDAQVLDEQF
LVLINDLLAS GEIPDLFSDE DTDNIISMVR SEIRKLGIID TRENCWKFFL ARVWKRLKIV
LCFSPVGYTL RRRARKFPAI VNGTAIDWFH DWPQEALLSV SGSFIEETEG IEPGHKDSIS
LFMAHVHTSV NEMSAKYHQN EQRHNYTTPK SFLSQICLYK NLLKKKQKEV AQRKEHLVNG
TQKLETTTSQ VEDLKAKLAS QEAELQQRNQ DAEALIMKIG LQTEKVSQEK AIADTEERKV
AAIQAEVFQK QRECEANLVK AEPVLVAARA ALNTLNRVNL TELKAFPNPP VAVTNVTAAV
MVLLAPGGRV PRDRSWKAAR VFMGKVDDFL QALINYDKEH IHENCLKVVY ENYLKDPEFS
PNLIRTKSFA AAGLCAWVIN IVKFYEVYCD VEPKRHALTQ ANMELAAATE KLEAIRKKLT
DLDHNLCGLK AAFEQAITEK VRCQEEVNQS SRNIGLANRL VMELQSEEIR WSQSIKSFED
QEKTLCGDVL LAAAFVSYIG PFTKQYRQEL IESKWIPFLR AQKVPIMECL DLISMLTDDA
TIAAWNNEGL PGDKMSTENA TILTNCERWP LMIDPQQQGI KWIKNKYGTD LKVLRLGQKG
FLNTIENALA SGEIVLIENL DETIDPVLDP LLGRNTIRRG KFIKIGDREC KFHKNFRLIL
HTKLANPHYQ PEVQAQTTLL NFTVTGDGLE DQLLAEVVSV DRPDLEKLKP QGKYRIIRSD
SMSFLHKADS LREEGKQVLN SVFNRRRVAP LTLSRVSMQV AEAKANEAQI NETRECYRPV
AARASLLYFV VHDLRKINPF YQFSLKAFNT LYHKAIRLAE RNEEMQERIS NLMESITYSV
FLFISQGLFE KDKLTFLSQA TFQILLRNKE IELLELDFLL RFPVEHTYKS PVDFLTAQSW
SAIKAISQMD DEFRGLDRDL EGSANRWKKW VESECPEKEK FPQEWKKKSS FQKLILLRAL
RPDRMTYALR NFVEEKLGAK YVDGTRMDLV KLLEESSPAM PLFFILSPGV DALKDLEILG
QKLGFTIDSG KFHNLSLGQG QEKVAEMTLE KASQEGQWVI LQNVHLVAKW LGTLEILLEQ
FSVESHCDYR VFLSAAPVPD DHQIPQGLLE NSIKITNEAP TGMLANLHAA LYNFDQDTLE
LCSKEQEFKS ILFSLCYFHA CVAGRLKFGP QGWNRSYPFN IGDLNICRSV LYNYLEANPK
VPWEDLRYLF GEIMYGGHIT DVWDRKLCRM YLEEFMNPSL CDGEFLLAPG FAAPGNLDYL
GYHQYVEENL PPESPVLYGL HPNAEIGFLT ETANNLFRNL MEIQPRHCSV QQELVKTVLD
HILEKLPEEF NLAEIAHKTT DRSPYVLVCF QECERMNTLI QEIRRSLEGL DLGLKGELTF
SPDMEALQFA LTYDTVPGTW TKLAYPSTSG LTQWVTDLLL RCRELDTWTQ DLVFPAVVWL
SGFFNPQSFL TAIMQSTARK NRWPLDKMCL TVDVTKKSRE DYGHPPREGA YIWGLHLEGA
RWDVQAGVLA EARLMELSHP MPVIFVKAVP VDRQELRHTY ECPVYKTKSR GPTYVWTFRL
KSRHKEAKWT LTGAALLLAV
//
